DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT1G53440

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_175749.1	Gene:	AT1G53440 / 841779	AraportID:	AT1G53440	Length:	1035	Species:	Arabidopsis thaliana

Alignment Length:	836	Identity:	184/836 - (22%)
Similarity:	298/836 - (35%)	Gaps:	232/836 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 KAGYEPNYTNKT------CTECPLGTFKS-PEVT---------KCTPCPPNSNASKTGSPFCKCA 368
            |...:.:|.|.|      |.:..:....| |.||         |..|||.:::.|   |.|..|.
plant   352 KQNIDLSYNNFTQPPTLSCNQLDVNLISSYPSVTNNSVQWCLRKDLPCPGDAHHS---SLFINCG 413

  Fly   369 SGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTS--AIISWSAPAKNESFSSETNSKIYHSDIVY 431
            ....:...|.                  :.|..:  ...::|:.::...:|| :.:.:.:....|
plant   414 GNRLKVDKDE------------------YADDLNKRGASTFSSVSERWGYSS-SGAWLGNDGATY 459

  Fly   432 KIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVS 496
            .              :|||||     |.|......|.....|..|:.:.....|..:....:..:
plant   460 L--------------ATDTFN-----LINESTPEYYKTARLASQSLKYYGLCMRRGSYKVQLYFA 505

  Fly   497 DIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPL 561
            :|:|||        |......|:.......:.:||...||:...|           ..|...|..
plant   506 EIMFSN--------DQTYSSLGRRLFDIYVQGILLERDFNIAQRA-----------GGVGKPFLR 551

  Fly   562 EFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQ- 625
            :..||:         :|.|.|     :.|    |:.|..|..| ..|.   |.|..:|.|.|:.
plant   552 QVDEVQ---------VNGSTL-----EIH----LKWTGKGTNV-IPTR---GVYGPLISAITVTP 594

  Fly   626 ----SVGSVYDDSVQIRFIAGAIVTGVL---FLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLD 683
                ..|....:.|    :||.::...:   .||:.|:....::..|..|:
plant   595 NFKVDTGKPLSNGV----VAGIVIAACVAFGLLVLVILRLTGYLGGKEVDE-------------- 641

  Fly   684 YASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIG 748
              :.|:..:|           :.|..|                 .:::..|.  .|....|..||
plant   642 --NEELRGLD-----------LQTGSF-----------------TLKQIKRA--TNNFDPENKIG 674

  Fly   749 GGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTR 813
            .|.||.|.:|.|      ...:.:|:|.|...|.:..| :|:||..::....|||::.|.|....
plant   675 EGGFGPVYKGVL------ADGMTIAVKQLSSKSKQGNR-EFVTEIGMISALQHPNLVKLYGCCIE 732

  Fly   814 SNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLR-----GIASGMSYL---SDMNYVHRDLA 870
            ...::::.||:||.||...|...:.  |.|.|....|     |||.|::||   |.:..||||:.
plant   733 GKELLLVYEYLENNSLARALFGTEK--QRLHLDWSTRNKVCIGIAKGLAYLHEESRLKIVHRDIK 795

  Fly   871 ARNVLVNAQLICKIADFGLSREIENASDAYTTR-GGKIPVRWTAPEAIAFRKFTSASDVWSYGVV 934
            |.|||::..|..||:||||::..|..:...:|| .|.|  .:.|||.......|..:||:|:|||
plant   796 ATNVLLDLSLNAKISDFGLAKLDEEENTHISTRIAGTI--GYMAPEYAMRGYLTDKADVYSFGVV 858

  Fly   935 LWEVMSYGE-----RPY--------WNWSNQD---VIKSIEKGYRLPAPMDCPEALYQL--MLDC 981
            ..|::| |:     ||.        |.:..|:   :::.::..  |.......||:..|  .|.|
plant   859 CLEIVS-GKSNTNYRPKEEFIYLLDWAYVLQEQGSLLELVDPD--LGTSFSKKEAMRMLNIALLC 920

  Fly   982 WQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDG-------NHILDGQRGQNIFIST--- 1036
            .....|.||..:|:||.|....:....|:.....|....       .|:......|   :||
plant   921 TNPSPTLRPPMSSVVSMLQGKIKVQPPLVKREADPSGSAAMRFKALEHLSQDSESQ---VSTYTR 982

  Fly  1037 -----------DLWLEHIKMSRYCHHFKEANLI-----NAQQISRLTAQQLSDMGI 1076
                       ..|::    |.:....|:.:|:     |:...||.....|:|:.|
plant   983 NKEHKSSSSMDGPWVD----SSFSDPSKDVSLLQQEEGNSSSSSRRLLDDLTDVEI 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	14/90 (16%)
		FN3	536..623	CDD:238020	19/86 (22%)
		EphA2_TM	644..736	CDD:291255	10/94 (11%)
		PTKc_EphR	736..1002	CDD:270629	91/292 (31%)
		Pkinase_Tyr	741..999	CDD:285015	89/284 (31%)
		SAM_1	1033..1092	CDD:278937	12/63 (19%)
		SAM	1039..1092	CDD:197735	10/43 (23%)
AT1G53440	NP_175749.1	PLN00113	74..939	CDD:215061	167/732 (23%)
		leucine-rich repeat	90..113	CDD:275380
		leucine-rich repeat	114..135	CDD:275380
		leucine-rich repeat	137..160	CDD:275380
		leucine-rich repeat	161..184	CDD:275380
		leucine-rich repeat	185..208	CDD:275380
		leucine-rich repeat	209..232	CDD:275380
		leucine-rich repeat	233..256	CDD:275380
		leucine-rich repeat	257..280	CDD:275380
		leucine-rich repeat	281..305	CDD:275380
		leucine-rich repeat	306..327	CDD:275380
		STKc_IRAK	673..940	CDD:270968	89/280 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050