DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and AT1G53430

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001319214.1	Gene:	AT1G53430 / 841778	AraportID:	AT1G53430	Length:	1038	Species:	Arabidopsis thaliana

Alignment Length:	740	Identity:	169/740 - (22%)
Similarity:	267/740 - (36%)	Gaps:	194/740 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 NYTNK---TCTECPLGTFKS-PEVTK-----C----TPCPPNSNASKTGSPFCKCASGFYRHPND 377
            |:|..   :|.:..:....| |.||.     |    .|||.:   :|..|.|..|.....:...|
plant   363 NFTQPPTLSCNQLDVNLISSYPSVTDNSVQWCLREGLPCPED---AKQSSLFINCGGSRLKIGKD 424

  Fly   378 GRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNV 442
                              .:.|..::       ....:|||.:....|.|..|:     :...:.
plant   425 ------------------TYTDDLNS-------RGQSTFSSVSERWGYSSSGVW-----LGKEDA 459

  Fly   443 VYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLN 507
            .| .:||.||     |.|......|.....:..|:.:.....|..:....:..::|:|||....|
plant   460 GY-LATDRFN-----LINGSTPEYYKTARLSPQSLKYYGLCLRRGSYKLQLHFAEIMFSNDQTFN 518

  Fly   508 IPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKV 572
                    ..|:.......:..||...||     |..:...:  .||.          :|....|
plant   519 --------SLGRRIFDIYVQGNLLERDFN-----IAERAGGV--GKPF----------IRQIDGV 558

  Fly   573 ELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGF---GSYSNMIYAQTLQ-----SVGS 629
            :   :|.|.|                |...|...|..|..   |.|..:|.|.|:.     ..|.
plant   559 Q---VNGSTL----------------EIHLQWTGKGTNVIPTRGVYGPLISAITITPNFKVDTGK 604

  Fly   630 -VYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMD 693
             :.:.:|....||...|.|:|.||  |:....::..|..|:                :.|:..:|
plant   605 PLSNGAVAGIVIAACAVFGLLVLV--ILRLTGYLGGKEVDE----------------NEELRGLD 651

  Fly   694 TTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRG 758
                       :.|..|                 .:::..|.  .|....|..||.|.||.|.:|
plant   652 -----------LQTGSF-----------------TLKQIKRA--TNNFDPENKIGEGGFGPVYKG 686

  Fly   759 RLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEY 823
            .|      ...:.:|:|.|...|.:..| :|:||..::....|||::.|.|.......::::.||
plant   687 VL------ADGMTIAVKQLSSKSKQGNR-EFVTEIGMISALQHPNLVKLYGCCIEGKELLLVYEY 744

  Fly   824 MENGSLDTFLRVNDGKFQTLQLIVMLR-----GIASGMSYL---SDMNYVHRDLAARNVLVNAQL 880
            :||.||...|...:.  |.|.|....|     |||.|::||   |.:..||||:.|.|||::..|
plant   745 LENNSLARALFGTEK--QRLHLDWSTRNKICIGIAKGLAYLHEESRLKIVHRDIKATNVLLDLSL 807

  Fly   881 ICKIADFGLSREIENASDAYTTR-GGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGE- 943
            ..||:||||::..::.:...:|| .|.|  .:.|||.......|..:||:|:|||..|::| |:
plant   808 NAKISDFGLAKLNDDENTHISTRIAGTI--GYMAPEYAMRGYLTDKADVYSFGVVCLEIVS-GKS 869

  Fly   944 ----RPY--------WNWSNQD---VIKSIEKGYRLPAPMDCPEALYQL--MLDCWQKQRTHRPT 991
                ||.        |.:..|:   :::.::..  |.......||:..|  .|.|.....|.||.
plant   870 NTNYRPKEEFVYLLDWAYVLQEQGSLLELVDPD--LGTSFSKKEAMRMLNIALLCTNPSPTLRPP 932

  Fly   992 FASIVSTLDNLARQPQSLLTTRPSP 1016
            .:|:||.|:...:....|:.....|
plant   933 MSSVVSMLEGKIKVQPPLVKREADP 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	15/88 (17%)
		FN3	536..623	CDD:238020	17/89 (19%)
		EphA2_TM	644..736	CDD:291255	13/91 (14%)
		PTKc_EphR	736..1002	CDD:270629	90/292 (31%)
		Pkinase_Tyr	741..999	CDD:285015	88/284 (31%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT1G53430	NP_001319214.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050