DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT1G51860

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_175598.1	Gene:	AT1G51860 / 841613	AraportID:	AT1G51860	Length:	890	Species:	Arabidopsis thaliana

Alignment Length:	768	Identity:	175/768 - (22%)
Similarity:	285/768 - (37%)	Gaps:	183/768 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 NDGRHMPCYSPPAAPTNLTLLFVDQTSAIIS--WSAPAKNESFSSETNSKIYHSDIVYK------ 432
            |...|...:..|.....:.|:....|:..||  ...|..|||:.:::.|.:..:.:.:.
plant   142 NTSMHEIIHVVPQDSLEVCLVKTGPTTPFISSLEVRPLNNESYLTQSGSLMLFARVYFPSSSSSF 206

  Fly   433 IKCNICSPNVVYNPSTDTFNETKITLTNLEPVTT---YTVQIHAINSVSHINEFKRHSNESSLVA 494
            |:.:....:.|:|..||  :||....|:| |:.|   |.:.    .||.......::::|..|:.
plant   207 IRYDEDIHDRVWNSFTD--DETVWISTDL-PIDTSNSYDMP----QSVMKTAAVPKNASEPWLLW 264

  Fly   495 VSDIVFSNTSLLNIPLDLNEV------KTGQAEIVFT----------TESVLLSTVFNLRILAIT 543
            .:  :..||:...:.:...||      :|.:..|.:.          ..::.:||:||.|.::.:
plant   265 WT--LDENTAQSYVYMHFAEVQNLTANETREFNITYNGGLRWFSYLRPPNLSISTIFNPRAVSSS 327

  Fly   544 NKDADLEWDKPVQSDFP-----LEFYEVRWFPKVELDAINKSA-LNTKETKAHIVGLLENTEYGF 602
            |...:..:.....|..|     ||.|.|....::|.:....|| :|.|||            ||.
plant   328 NGIFNFTFAMTGNSTLPPLLNALEIYTVVDILQLETNKDEVSAMMNIKET------------YGL 380

  Fly   603 QVRCKTNNGFGSYSNMIYAQTL---QSVGSVYDDSVQIRFIA---------GAIVTGVLFLVIFI 655
            ..:.       |:.....|..|   :.:...|.||...|.|:         |:|.:.:..|.:..
plant   381 SKKI-------SWQGDPCAPQLYRWEGLNCSYPDSEGSRIISLNLNGSELTGSITSDISKLTLLT 438

  Fly   656 IATV-----------YF--MRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVT- 706
            :..:           :|  |:|....:|......:|....|.....|||...|.|:.:   |:|
plant   439 VLDLSNNDLSGDIPTFFAEMKSLKLINLSGNPNLNLTAIPDSLQQRVNSKSLTLILGE---NLTL 500

  Fly   707 TP----------------------------LFGNSRSYVDPHTYEDPNQ-----AIREFAREIDA 738
            ||                            .|...|..|..|....|..     .::...|..:.
plant   501 TPKKESKKVPMVAIAASVAGVFALLVILAIFFVIKRKNVKAHKSPGPPPLVTPGIVKSETRSSNP 565

  Fly   739 NYIT----------------IEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARC 787
            :.||                .|.::|.|.||.|..|.|       ...:||:|.|...|::..:
plant   566 SIITRERKITYPEVLKMTNNFERVLGKGGFGTVYHGNL-------DGAEVAVKMLSHSSAQGYK- 622

  Fly   788 DFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSL-DTFLRVNDGKFQT----LQLIV 847
            :|..|..::.:..|.:::.|.|.....:.:.:|.|||.||.| :.......|...|    :|:.|
plant   623 EFKAEVELLLRVHHRHLVGLVGYCDDGDNLALIYEYMANGDLRENMSGKRGGNVLTWENRMQIAV 687

  Fly   848 MLRGIASGMSYLSD---MNYVHRDLAARNVLVNAQLICKIADFGLSRE--IENASDAYTTRGGKI 907
               ..|.|:.||.:   ...||||:...|:|:|.:...|:|||||||.  |:......|...|
plant   688 ---EAAQGLEYLHNGCRPPMVHRDVKTTNILLNERCGAKLADFGLSRSFPIDGECHVSTVVAG-- 747

  Fly   908 PVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMS-------YGERPYWN-W----SNQDVIKSIEK 960
            ...:..||.......:..|||:|:||||.|:::       ..|||:.| |    ..:..||||..
plant   748 TPGYLDPEYYRTNWLSEKSDVYSFGVVLLEIVTNQPVIDKTRERPHINDWVGFMLTKGDIKSIVD 812

  Fly   961 GYRLPAPMDCPEA--LYQLMLDCWQKQRTHRPTFASIVS------TLDNLARQ 1005
            . :|....|...|  :.:|.|.|.......|||.|.:|.      .|:|..||
plant   813 P-KLMGDYDTNGAWKIVELALACVNPSSNRRPTMAHVVMELNDCVALENARRQ 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	22/99 (22%)
		FN3	536..623	CDD:238020	20/92 (22%)
		EphA2_TM	644..736	CDD:291255	23/138 (17%)
		PTKc_EphR	736..1002	CDD:270629	85/311 (27%)
		Pkinase_Tyr	741..999	CDD:285015	84/303 (28%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT1G51860	NP_175598.1	Malectin_like	32..354	CDD:289580	44/220 (20%)
		leucine-rich repeat	415..436	CDD:275380	3/20 (15%)
		leucine-rich repeat	437..460	CDD:275380	2/22 (9%)
		leucine-rich repeat	461..489	CDD:275380	6/27 (22%)
		STYKc	586..849	CDD:214568	81/276 (29%)
		STKc_IRAK	590..853	CDD:270968	81/276 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050