DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT1G51830

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001323323.1	Gene:	AT1G51830 / 841610	AraportID:	AT1G51830	Length:	700	Species:	Arabidopsis thaliana

Alignment Length:	762	Identity:	171/762 - (22%)
Similarity:	269/762 - (35%)	Gaps:	215/762 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 PAKNESFSSETNSKIYHSDIVYKIKCNICSP-----------NVVY--NPSTDTF---------- 451
            |....|::..|.:...:...:|::..::.|.           |:.:  .|.|..|
plant    30 PIFQNSWTQVTTNLNVNISTIYELPQSVMSTAATPLNANATLNITWTIEPPTTPFYSYIHFAELQ 94

  Fly   452 ----NETK---ITLT--------NLEPVTTYTVQ---------------------------IHAI 474
                |:|:   :||.        :.:|:.|.|:|                           ::||
plant    95 SLRANDTREFNVTLNGEYTIGPYSPKPLKTETIQDLSPEQCNGGACILQLVETLKSTLPPLLNAI 159

  Fly   475 NSVSHINEFKRHSNESSLVAVSDIVFSNTSLLN---------IP-------LDLNEVKTGQAEIV 523
            .:.:.|:..:..:||..:..::|:  .||..||         :|       |:.|........|:
plant   160 EAFTVIDFPQMETNEDDVTGINDV--QNTYGLNRISWQGDPCVPKQYSWDGLNCNNSDISIPPII 222

  Fly   524 FTTE--SVLLSTVFNLRILAITN-KDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSA---L 582
            .:.:  |..|:.|....|..:|: :..||. |..:..|.|....:::....:.|...|.:.   |
plant   223 ISLDLSSSGLNGVITQGIQNLTHLQYLDLS-DNNLTGDIPKFLADIQSLLVINLSGNNLTGSVPL 286

  Fly   583 NTKETKAHIVGLLENTEYGFQVRCK----TNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGA 643
            :..:.|    ||..|.|....:.|.    .|.|.|.....|.|..:.|:.|       |..:.||
plant   287 SLLQKK----GLKLNVEGNPHLLCTDGLCVNKGDGHKKKSIIAPVVASIAS-------IAILIGA 340

  Fly   644 IVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDY--ASNEVNSMDTTPIVKKLHLNVT 706
            :   |||.|:                  ||.|.....|..|  |||
plant   341 L---VLFFVL------------------KKKTQSKGPPAAYVQASN------------------- 365

  Fly   707 TPLFGNSRSYVDP--------HTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIP 763
                |.||...:|        .||.:..|....|.|           ::|.|.||.|..|.:
plant   366 ----GRSRRSAEPAIVTKNKRFTYSEVMQMTNNFQR-----------VLGKGGFGIVYHGLV--- 412

  Fly   764 PNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGS 828
             |..:  .||||.|...||:..: .|..|..::.:..|.|::.|.|.......:.:|.|||.||.
plant   413 -NGTE--QVAIKILSHSSSQGYK-QFKAEVELLLRVHHKNLVGLVGYCDEGENLALIYEYMANGD 473

  Fly   829 LDTFLRVNDGKF-----QTLQLIVMLRGIASGMSYLSD---MNYVHRDLAARNVLVNAQLICKIA 885
            |...:......|     ..|:::|   ..|.|:.||.:   ...||||:...|:|:|.|...|:|
plant   474 LKEHMSGTRNHFILNWGTRLKIVV---ESAQGLEYLHNGCKPLMVHRDIKTTNILLNEQFDAKLA 535

  Fly   886 DFGLSRE--IENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMS-------Y 941
            ||||||.  ||..:...|...|  ...:..||.......|..|||:|:||||.|:::       .
plant   536 DFGLSRSFPIEGETHVSTAVAG--TPGYLDPEYYRTNWLTEKSDVYSFGVVLLEIITNQPVIDPR 598

  Fly   942 GERPY-WNWSNQDVIKSIEKGYRLPA---PMDCPEA--LYQLMLDCWQKQRTHRPTFASIVSTLD 1000
            .|:|: ..|..:.:.|...|....|:   ..|....  ..:|.:.|.......||..:.:|..|:
plant   599 REKPHIAEWVGEVLTKGDIKNIMDPSLNGDYDSTSVWKAVELAMCCLNPSSARRPNMSQVVIELN 663

  Fly  1001 NLARQPQSLLTTRPSPESDGNHILDGQRGQNIFISTDLWLEHIKMSR 1047
                   ..||   |..|.|..|.|.....:|.:|.....|...::|
plant   664 -------ECLT---SENSRGGAIRDMDSEGSIEVSLTFGTEVTPLAR 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	19/130 (15%)
		FN3	536..623	CDD:238020	21/94 (22%)
		EphA2_TM	644..736	CDD:291255	21/101 (21%)
		PTKc_EphR	736..1002	CDD:270629	79/288 (27%)
		Pkinase_Tyr	741..999	CDD:285015	78/280 (28%)
		SAM_1	1033..1092	CDD:278937	3/15 (20%)
		SAM	1039..1092	CDD:197735	2/9 (22%)
AT1G51830	NP_001323323.1	Malectin_like	<17..164	CDD:403886	19/133 (14%)
		PLN00113	206..>298	CDD:215061	19/96 (20%)
		leucine-rich repeat	225..245	CDD:275380	4/19 (21%)
		leucine-rich repeat	246..269	CDD:275380	5/23 (22%)
		leucine-rich repeat	270..294	CDD:275380	4/27 (15%)
		STKc_IRAK	399..664	CDD:270968	79/283 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050