DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT1G51820

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_175594.2	Gene:	AT1G51820 / 841609	AraportID:	AT1G51820	Length:	885	Species:	Arabidopsis thaliana

Alignment Length:	971	Identity:	201/971 - (20%)
Similarity:	336/971 - (34%)	Gaps:	288/971 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 DCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIA-RIAAGE-GRFNQNSDVDINTEV 228
            ||.|            |||...:||      |....:|...| .:|:|: ||..:..:..::...
plant    30 DCGL------------SLLESPYDA------PQTGLTYTSDADLVASGKTGRLAKEFEPLVDKPT 76

  Fly   229 KSIAVNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETP------------------ 275
            .::....:||...:.     ::|.:...|.|....|..|:...|..|
plant    77 LTLRYFPEGVRNCYN-----LNVTSDTNYLIKATFVYGNYDGLNVGPNFNLYLGPNLWTTVSSND 136

  Fly   276 TGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTF 340
            |..||.::.:.|...|                         |..|.|....:.|
plant   137 TIEEIILVTRSNSLQV-------------------------CLVKTGISIPFIN----------- 165

  Fly   341 KSPEVTKCTPCPPNSNASKTGS------PFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVD 399
                :.:..|...|...:::||      .:...:|...|.|:|......|.          ||.|
plant   166 ----MLELRPMKKNMYVTQSGSLKYLFRGYISNSSTRIRFPDDVYDRKWYP----------LFDD 216

  Fly   400 QTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPV 464
                  ||:        ...||.|: ::.|.|::..::.:.......:.||.|   ||.| :||.
plant   217 ------SWT--------QVTTNLKV-NTSITYELPQSVMAKAATPIKANDTLN---ITWT-VEPP 262

  Fly   465 TTYTVQIHAINSVSHINEFK-RHSNESSLVAVSDIVFSNTSLLNIPL---DLNEVKTGQA----- 520
            ||   |.::...::.|...: ..:.|.::....:..|...|  .|||   .:.::..||.
plant   263 TT---QFYSYVHIAEIQALRANETREFNVTLNGEYTFGPFS--PIPLKTASIVDLSPGQCDGGRC 322

  Fly   521 --EIVFTTESV---LLSTVFNLRILAI----TNKDADLEWDKPVQSDFPLEFYEVRW-----FPK 571
              ::|.|.:|.   ||:.:....::..    ||:: |:...|.||..:.|.  .:.|     .||
plant   323 ILQVVKTLKSTLPPLLNAIEAFTVIDFPQMETNEN-DVAGIKNVQGTYGLS--RISWQGDPCVPK 384

  Fly   572 VEL-DAIN--KSALNTKE-----------------------TKAHIVGLLENTEYG----FQVRC 606
            ..| |.:|  .|.::|..                       |...|:.|.:|...|    |....
plant   385 QLLWDGLNCKNSDISTPPIITSLDLSSSGLTGIITQAIKNLTHLQILDLSDNNLTGEVPEFLADI 449

  Fly   607 KT----NNGFGSYSNMIYAQTLQSVGSV--YDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSK 665
            |:    |....:.|..:....||..|..  .:.:..|....|:.|                   |
plant   450 KSLLVINLSGNNLSGSVPPSLLQKKGMKLNVEGNPHILCTTGSCV-------------------K 495

  Fly   666 HQDDLDKKSTNHLPLPLDYASNEV--NSMDTTPIVKKLHLNVTTPLFGNSRSYV---DPHTYEDP 725
            .::|..||.:..:|:....||..|  .::....|::|..   :..:.|...||:   |.......
plant   496 KKEDGHKKKSVIVPVVASIASIAVLIGALVLFLILRKKR---SPKVEGPPPSYMQASDGRLPRSS 557

  Fly   726 NQAIREFAREIDANYITI-----EAIIGGGEFGDVCRGRLKIPPNFVQDID-VAIKTLKPGSSEK 784
            ..||....|....:.:.|     :.|:|.|.||.|..|       ||...: ||:|.|...||:.
plant   558 EPAIVTKNRRFSYSQVVIMTNNFQRILGKGGFGMVYHG-------FVNGTEQVAVKILSHSSSQG 615

  Fly   785 ARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKF-----QTLQ 844
            .: .|..|..::.:..|.|::.|.|.....:.:.:|.|||.||.|...:.....:|     ..|:
plant   616 YK-QFKAEVELLLRVHHKNLVGLVGYCDEGDNLALIYEYMANGDLKEHMSGTRNRFILNWGTRLK 679

  Fly   845 LIVMLRGIASGMSYLSD---MNYVHRDLAARNVLVNAQLICKIADFGLSRE--IENASDAYTTRG 904
            :::   ..|.|:.||.:   ...||||:...|:|:|.....|:|||||||.  ||..:...|...
plant   680 IVI---ESAQGLEYLHNGCKPPMVHRDVKTTNILLNEHFEAKLADFGLSRSFLIEGETHVSTVVA 741

  Fly   905 GKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMS-------YGERPY---W------------ 947
            |  ...:..||.......|..|||:|:|::|.|:::       ..|:|:   |
plant   742 G--TPGYLDPEYHRTNWLTEKSDVYSFGILLLEIITNRHVIDQSREKPHIGEWVGVMLTKGDIQS 804

  Fly   948 --------NWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLD 1000
                    ::.:..|.|::|                 |.:.|.......|||.:.:|..|:
plant   805 IMDPSLNEDYDSGSVWKAVE-----------------LAMSCLNHSSARRPTMSQVVIELN 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	19/95 (20%)
		FN3	387..476	CDD:238020	21/88 (24%)
		FN3	536..623	CDD:238020	24/129 (19%)
		EphA2_TM	644..736	CDD:291255	18/96 (19%)
		PTKc_EphR	736..1002	CDD:270629	77/311 (25%)
		Pkinase_Tyr	741..999	CDD:285015	76/303 (25%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT1G51820	NP_175594.2	Malectin_like	29..345	CDD:289580	77/411 (19%)
		LRR_8	405..462	CDD:290566	8/56 (14%)
		leucine-rich repeat	405..427	CDD:275380	0/21 (0%)
		leucine-rich repeat	428..451	CDD:275380	5/22 (23%)
		leucine-rich repeat	452..468	CDD:275380	2/15 (13%)
		TyrKc	580..847	CDD:197581	75/296 (25%)
		STKc_IRAK	584..849	CDD:270968	75/295 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050