DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT1G51810

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_175593.2	Gene:	AT1G51810 / 841608	AraportID:	AT1G51810	Length:	744	Species:	Arabidopsis thaliana

Alignment Length:	751	Identity:	161/751 - (21%)
Similarity:	267/751 - (35%)	Gaps:	236/751 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 PAKNESFSSETNS-----KIYHSDIVYKIK------------------CNICSPNVVYNPSTDTF 451
            |..::.:::|:.|     ::|:|::...|:                  ..|.:.|:..|.|.|..
plant    44 PLADDIYTNESGSLNYLFRVYYSNLKGYIEYPDDVHDRIWKQILPYQDWQILTTNLQINVSNDYD 108

  Fly   452 NETKITLTNLEPV----TTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDL 512
            ...::..|.:.|:    ||.....:.....|....|...:...||.|      :.|...|:.|:.
plant   109 LPQRVMKTAVTPIKASTTTMEFPWNLEPPTSQFYLFLHFAELQSLQA------NETREFNVVLNG 167

  Fly   513 NEVKTGQAEIVFTTES---VLLSTVFNLRILAITNKDAD-----LEWDKPVQSDFP-----LEFY 564
            |        :.|.:.|   :.:.||:     :...|..|     |:..|..:|..|     :|.|
plant   168 N--------VTFKSYSPKFLEMQTVY-----STAPKQCDGGKCLLQLVKTSRSTLPPLINAMEAY 219

  Fly   565 EVRWFPKVELDAINKSAL-NTKETKAHIVGLLENTEYGFQ----------VRCKTNNGFGSYSNM 618
            .|..||::|.:.....|: |.:.|    .||.:.|..|..          :.|  ||...|...:
plant   220 TVLDFPQIETNVDEVIAIKNIQST----YGLSKTTWQGDPCVPKKFLWDGLNC--NNSDDSTPPI 278

  Fly   619 IYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTN---HLP- 679
            |.:..|.|.|                :||::.|.|..:|.:        .:||..:.|   .:|
plant   279 ITSLNLSSSG----------------LTGIIVLTIQNLANL--------QELDLSNNNLSGGVPE 319

  Fly   680 --------LPLDYASNEVNSMDTTPIVKK--LHLNV---------------------------TT 707
                    |.::.:.|.::.:....:::|  |.||:                           |.
plant   320 FLADMKSLLVINLSGNNLSGVVPQKLIEKKMLKLNIEGNPKLNCTVESCVNKDEEGGRQIKSMTI 384

  Fly   708 PLFGNSRSYV---------------DPHTYEDPNQA-IREFAREIDANYIT-------------- 742
            |:..:..|.|               :|...|.|... :...:|..:...:|
plant   385 PIVASIGSVVAFTVALMIFCVVRKNNPSNDEAPTSCMLPADSRSSEPTIVTKNKKFTYAEVLTMT 449

  Fly   743 --IEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVI 805
              .:.|:|.|.||.|..|.:    |..:  .||:|.|...|::..: .|..|..::.:..|.|::
plant   450 NNFQKILGKGGFGIVYYGSV----NGTE--QVAVKMLSHSSAQGYK-QFKAEVELLLRVHHKNLV 507

  Fly   806 YLQGVVTRSNPVMIITEYMENGSLDTFLR-------VNDGKFQTLQLIVMLRGIASGMSYLSD-- 861
            .|.|.....:.:.:|.|||.||.||..:.       :|.|    .:|.:.|.. |.|:.||.:
plant   508 GLVGYCEEGDKLALIYEYMANGDLDEHMSGKRGGSILNWG----TRLKIALEA-AQGLEYLHNGC 567

  Fly   862 -MNYVHRDLAARNVLVNAQLICKIADFGLSRE--IENASDAYTTRGGKIPVRWTAPEAIAFRKFT 923
             ...||||:...|:|:|.....|:|||||||.  ||..:...|...|.|  .:..||.......|
plant   568 KPLMVHRDVKTTNILLNEHFDTKLADFGLSRSFPIEGETHVSTVVAGTI--GYLDPEYYRTNWLT 630

  Fly   924 SASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKS--------------IEKGYRLPAPMDCPEAL 974
            ..|||:|:||||..::          :||.||..              :.|| .:.:..| |..|
plant   631 EKSDVYSFGVVLLVMI----------TNQPVIDQNREKRHIAEWVGGMLTKG-DIKSITD-PNLL 683

  Fly   975 -----------YQLMLDCWQKQRTHRPTFASIVSTL 999
                       .:|.:.|.......|||.:.:|..|
plant   684 GDYNSGSVWKAVELAMSCMNPSSMTRPTMSQVVFEL 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	15/92 (16%)
		FN3	536..623	CDD:238020	24/107 (22%)
		EphA2_TM	644..736	CDD:291255	23/148 (16%)
		PTKc_EphR	736..1002	CDD:270629	83/317 (26%)
		Pkinase_Tyr	741..999	CDD:285015	82/310 (26%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT1G51810	NP_175593.2	Malectin_like	<2..220	CDD:289580	35/194 (18%)
		LRR_8	280..337	CDD:290566	14/80 (18%)
		leucine-rich repeat	280..302	CDD:275380	7/37 (19%)
		leucine-rich repeat	303..326	CDD:275380	4/30 (13%)
		S_TKc	454..715	CDD:214567	80/286 (28%)
		STKc_IRAK	456..721	CDD:270968	81/290 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050