DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and IOS1

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_175591.1	Gene:	IOS1 / 841606	AraportID:	AT1G51800	Length:	894	Species:	Arabidopsis thaliana

Alignment Length:	735	Identity:	172/735 - (23%)
Similarity:	264/735 - (35%)	Gaps:	201/735 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   406 SWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQ 470
            :||..:.|:|.:...:   |....:..:..::         .||......|:|..:|    .|||
plant   223 NWSQISTNQSVNINND---YQPPEIAMVTASV---------PTDPDAAMNISLVGVE----RTVQ 271

  Fly   471 IHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVF 535
            .:.....:.|.|.|  ||::   ...:|:::|..:......||          |||.||...|
plant   272 FYVFMHFAEIQELK--SNDT---REFNIMYNNKHIYGPFRPLN----------FTTSSVFTPT-- 319

  Fly   536 NLRILAITNKDADLEWDKPVQSDFP-----LEFYEVRWFPKVELD--------------AINK-- 579
              .::|..|........:...|..|     :|.|.|...|:.|.|              .:||
plant   320 --EVVADANGQYIFSLQRTGNSTLPPLLNAMEIYSVNLLPQQETDRKEVDAMMNIKSAYGVNKID 382

  Fly   580 -------------SALN----TKETKAHI------VGLL-ENTEY-----GFQVRCKTNNGF-GS 614
                         |.:|    ..||...|      .||. |..|:     ..:|...:||.. ||
plant   383 WEGDPCVPLDYKWSGVNCTYVDNETPKIISLDLSTSGLTGEILEFISDLTSLEVLDLSNNSLTGS 447

  Fly   615 ----YSNMIYAQTLQSVGSVYDDSVQIRFI----AGAIVTGVLFLVIFIIATVYFMRSKHQDDLD 671
                .:||...:.:...|:..:.|:....:    .|:|       .:.|........|.......
plant   448 VPEFLANMETLKLINLSGNELNGSIPATLLDKERRGSI-------TLSIEGNTGLCSSTSCATTK 505

  Fly   672 KKSTNHLPLPLDYASNEVN------SMDTTPIVK-----KLHLNV-----TTPLFGNSRSYVDPH 720
            ||..|.:..|:  |::.|:      .:.|..|:|     ||.||.     ||||  :|||:   |
plant   506 KKKKNTVIAPV--AASLVSVFLIGAGIVTFLILKRKKRTKLGLNPNSGTGTTPL--HSRSH---H 563

  Fly   721 TYEDPNQAIREFAREIDANYIT--IEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSE 783
            .:|.|..|.......||...||  .|.::|.|.||.|..|.|...|       ||:|.|.. |:.
plant   564 GFEPPVIAKNRKLTYIDVVKITNNFERVLGRGGFGVVYYGVLNNEP-------VAVKMLTE-STA 620

  Fly   784 KARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVM 848
            .....|..|..::.:..|.::..|.|.....:.:.:|.|:|.||.|...|....|     ..|:.
plant   621 LGYKQFKAEVELLLRVHHKDLTCLVGYCEEGDKMSLIYEFMANGDLKEHLSGKRG-----PSILT 680

  Fly   849 LRG-------IASGMSYLSD---MNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYT-- 901
            ..|       .|.|:.||.:   ...||||:...|:|:|.:...|:|||||||.....::.:.
plant   681 WEGRLRIAAESAQGLEYLHNGCKPQIVHRDIKTTNILLNEKFQAKLADFGLSRSFPLGTETHVST 745

  Fly   902 ----TRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVI-KSIEKG 961
                |.|      :..||.......|..|||:|:||||.|::          :||.|| ...||.
plant   746 IVAGTPG------YLDPEYYRTNWLTEKSDVFSFGVVLLELV----------TNQPVIDMKREKS 794

  Fly   962 Y--------------------RLPAPMDCPEALYQLM---LDCWQKQRTHRPTFASIVSTLD--- 1000
            :                    :|....| |..:::::   :.|.....:.|||...:|..|.
plant   795 HIAEWVGLMLSRGDINSIVDPKLQGDFD-PNTIWKVVETAMTCLNPSSSRRPTMTQVVMDLKECL 858

  Fly  1001 --NLARQPQSLLTTRPSPES 1018
              .:||...|.:|...:..|
plant   859 NMEMARNMGSRMTDSTNDSS 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	13/69 (19%)
		FN3	536..623	CDD:238020	28/141 (20%)
		EphA2_TM	644..736	CDD:291255	27/107 (25%)
		PTKc_EphR	736..1002	CDD:270629	81/312 (26%)
		Pkinase_Tyr	741..999	CDD:285015	78/299 (26%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
IOS1	NP_175591.1	Malectin_like	32..352	CDD:315486	33/163 (20%)
		PLN00113	<409..>498	CDD:331614	17/95 (18%)
		leucine-rich repeat	412..433	CDD:275380	4/20 (20%)
		leucine-rich repeat	434..457	CDD:275380	7/22 (32%)
		STKc_IRAK	592..856	CDD:270968	76/293 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050