DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and AT1G29720

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_564335.3	Gene:	AT1G29720 / 839850	AraportID:	AT1G29720	Length:	1019	Species:	Arabidopsis thaliana

Alignment Length:	668	Identity:	147/668 - (22%)
Similarity:	244/668 - (36%)	Gaps:	164/668 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 NSKIY----HSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTT------YTVQIH--- 472
            ||:.|    :::..:...|...|....|..|     .:|..||.|.|...      |...:|
plant   352 NSQSYIDLSYNNFSWSSSCQKGSTINTYQSS-----YSKNNLTGLPPCAVPANCKKYQRFLHINC 411

  Fly   473 ---------AINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTES 528
                     ::..:::..:..|.:|.:|.........|||.      |..:..:...|...:|..
plant   412 GGEEVSIRNSLGKITYQTDNSRQTNAASNQQFDYWGVSNTG------DFTDDNSDHDEYYTSTNL 470

  Fly   529 VL---------------LSTVFNLRILAITNKDADLEW------DKPVQSDFPLEFYEVRWFPKV 572
            .|               ||.|:....|...|.:..|.:      ||.|.|......::|....|:
plant   471 TLSGDYPDLYKTARRSALSLVYYAFCLENGNYNVKLHFMEIQFSDKEVYSRLGRRIFDVYVQGKL 535

  Fly   573 ELD--AINKSALNT-----KETKAHIVGLLENTEYGFQVRCK-TNNGF------GSYSNMIYAQT 623
            .|.  .|||.|...     ||..|.:      |.:..::|.. ...|.      |:|..:|.|.:
plant   536 FLRDFNINKEANGNMKPVIKEINATV------TNHMLEIRLYWAGKGTTLIPKRGNYGPLISAIS 594

  Fly   624 L----QSVGSVYDDSVQIRF-----IAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLP 679
            |    :.:..|......|::     .:||:|| ::.|.:.|.|...:.|..::.:.|.::.
plant   595 LCHSQEPLCGVEKTKHHIKYPLILGASGALVT-IVLLAVGIYARGIYRRDNNRRERDLRAQ---- 654

  Fly   680 LPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIE 744
                                    .:.|..|...:.....:.::..|:
plant   655 ------------------------GLQTVCFSWRQLQTATNNFDQANK----------------- 678

  Fly   745 AIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQG 809
              :|.|.||.|.:|.|.      ....:|:|.|...||:..| :|:.|..::...:|||::.|.|
plant   679 --LGEGGFGSVFKGELS------DGTIIAVKQLSSKSSQGNR-EFVNEIGMISGLNHPNLVKLYG 734

  Fly   810 VVTRSNPVMIITEYMENGSLDTFL-RVNDGKFQTLQLIVMLRGIASGMSYLSD---MNYVHRDLA 870
            .....:.::::.|||||.||...| ..|..|........:..|||.|:.:|.|   |..||||:.
plant   735 CCVERDQLLLVYEYMENNSLALALFGQNSLKLDWAARQKICVGIARGLEFLHDGSAMRMVHRDIK 799

  Fly   871 ARNVLVNAQLICKIADFGLSR--EIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGV 933
            ..|||::..|..||:||||:|  |.|:...:....|   .:.:.|||...:.:.|..:||:|:||
plant   800 TTNVLLDTDLNAKISDFGLARLHEAEHTHISTKVAG---TIGYMAPEYALWGQLTEKADVYSFGV 861

  Fly   934 VLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLM----------------LDCW 982
            |..|::| |:.......|.|.:..|.....|....|..|.:.:::                |.|.
plant   862 VAMEIVS-GKSNTKQQGNADSVSLINWALTLQQTGDILEIVDRMLEGEFNRSEAVRMIKVALVCT 925

  Fly   983 QKQRTHRPTFASIVSTLD 1000
            ....:.|||.:..|..|:
plant   926 NSSPSLRPTMSEAVKMLE 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	14/76 (18%)
		FN3	536..623	CDD:238020	24/106 (23%)
		EphA2_TM	644..736	CDD:291255	10/91 (11%)
		PTKc_EphR	736..1002	CDD:270629	81/287 (28%)
		Pkinase_Tyr	741..999	CDD:285015	80/279 (29%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT1G29720	NP_564335.3	leucine-rich repeat	120..143	CDD:275380
		LRR	<144..>365	CDD:227223	3/12 (25%)
		leucine-rich repeat	144..167	CDD:275380
		leucine-rich repeat	168..191	CDD:275380
		leucine-rich repeat	192..215	CDD:275380
		leucine-rich repeat	216..239	CDD:275380
		leucine-rich repeat	264..309	CDD:275380
		leucine-rich repeat	333..352	CDD:275380	147/668 (22%)
		Malectin	407..593	CDD:288557	37/197 (19%)
		STYKc	678..942	CDD:214568	80/293 (27%)
		STKc_IRAK	679..944	CDD:270968	81/276 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050