DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT1G27190

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_174039.1	Gene:	AT1G27190 / 839608	AraportID:	AT1G27190	Length:	601	Species:	Arabidopsis thaliana

Alignment Length:	670	Identity:	136/670 - (20%)
Similarity:	251/670 - (37%)	Gaps:	192/670 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 VDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLE 462
            :|.:|.:.|||.|  |.|.||                  ||....|     ..:||.:..:.:|
plant    39 IDPSSRLSSWSFP--NSSASS------------------ICKLTGV-----SCWNEKENRIISL- 77

  Fly   463 PVTTYTVQIHAINSVSHINEFKR--HSNESSLVAVSDIVFSNTSLL------NIPLDLNEVKTGQ 519
                   |:.::.....|.|..:  .|.:|..::.:|:..|..|.:      .:.|||:..|.|.
plant    78 -------QLQSMQLAGEIPESLKLCRSLQSLDLSGNDLSGSIPSQICSWLPYLVTLDLSGNKLGG 135

  Fly   520 AEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNT 584
            :......|...|    |..||:          |..:....|.:.        ..||.:.:.:|..
plant   136 SIPTQIVECKFL----NALILS----------DNKLSGSIPSQL--------SRLDRLRRLSLAG 178

  Fly   585 KETKAHIVGLLENTEYGFQVRCKTNNGFG----SYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIV 645
            .:....|...|..              ||    |.:|.:..:.|...|::...::.|..:||.:.
plant   179 NDLSGTIPSELAR--------------FGGDDFSGNNGLCGKPLSRCGALNGRNLSIIIVAGVLG 229

  Fly   646 TGVLFLVIFIIATVYFMR-----------SKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVK 699
            ......|..:|...:|:|           .|.:||.|     .:.|...:...:| ::...||||
plant   230 AVGSLCVGLVIFWWFFIREGSRKKKGYGAGKSKDDSD-----WIGLLRSHKLVQV-TLFQKPIVK 288

  Fly   700 -KL-HLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKI 762
             || .|...|..|.:....|...|                  .::.:|.:..|.
plant   289 IKLGDLMAATNNFSSGNIDVSSRT------------------GVSYKADLPDGS----------- 324

  Fly   763 PPNFVQDIDVAIKTLKP-GSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMEN 826
                    .:|:|.|.. |..||   .|.:|.:.:|:..|||::.|.|.....:..:::.::|.|
plant   325 --------ALAVKRLSACGFGEK---QFRSEMNKLGELRHPNLVPLLGYCVVEDERLLVYKHMVN 378

  Fly   827 GSLDTFLRVNDG-------KFQTLQLIVMLRGIASGMSYL---SDMNYVHRDLAARNVLVNAQLI 881
            |:|  |.::::|       .:.|.:.|.:  |.|.|:::|   ....|:|:.:::..:|::....
plant   379 GTL--FSQLHNGGLCDAVLDWPTRRAIGV--GAAKGLAWLHHGCQPPYLHQFISSNVILLDDDFD 439

  Fly   882 CKIADFGLSREI--ENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGER 944
            .:|.|:||::.:  .:::|:....|....:.:.|||..:....:...||:.:|:||.|::: |::
plant   440 ARITDYGLAKLVGSRDSNDSSFNNGDLGELGYVAPEYSSTMVASLKGDVYGFGIVLLELVT-GQK 503

  Fly   945 P-------------YWNWSNQ--------DVI-KSI-EKGYRLPAPMDCPEALYQLM---LDCWQ 983
            |             ..:|.:|        |.| :|| :||:        .|.:.|.:   ..|..
plant   504 PLSVINGVEGFKGSLVDWVSQYLGTGRSKDAIDRSICDKGH--------DEEILQFLKIACSCVV 560

  Fly   984 KQRTHRPTFASIVSTLDNLA 1003
            .:...|||...:..:|.|:|
plant   561 SRPKERPTMIQVYESLKNMA 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	17/77 (22%)
		FN3	536..623	CDD:238020	14/90 (16%)
		EphA2_TM	644..736	CDD:291255	21/104 (20%)
		PTKc_EphR	736..1002	CDD:270629	63/304 (21%)
		Pkinase_Tyr	741..999	CDD:285015	62/296 (21%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT1G27190	NP_174039.1	PLN00113	4..>191	CDD:215061	41/206 (20%)
		leucine-rich repeat	77..97	CDD:275380	4/27 (15%)
		leucine-rich repeat	98..122	CDD:275380	4/23 (17%)
		leucine-rich repeat	123..146	CDD:275380	6/22 (27%)
		STKc_IRAK	309..579	CDD:270968	64/322 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050