DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and EDR1

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_563824.1	Gene:	EDR1 / 837393	AraportID:	AT1G08720	Length:	933	Species:	Arabidopsis thaliana

Alignment Length:	868	Identity:	189/868 - (21%)
Similarity:	300/868 - (34%)	Gaps:	267/868 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 DSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYFA--FRDQGACISVLAVKVYYITCPA 263
            ||.||..|:..| ..:..|.|..:||    |.:..:..|..  ..|.|..|            ||
plant   282 DSVRLPCRLVKG-SHYTGNEDDAVNT----IRLEDEREYLVDLMTDPGTLI------------PA 329

  Fly   264 VTENFAHFNETPTGREITIIEKQNGT---CVDNAEPYETPTY------LCKGDGKWTILTGGCRC 319
               :||              ...|.|   |..|...:.|..:      |.:|:|      .....
plant   330 ---DFA--------------SASNNTVEPCNSNGNKFPTAQFSNDVPKLSEGEG------SSHSS 371

  Fly   320 KAGYEPNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCY 384
            .|.|..:...:|                        .|.:|.|.:.|.  |..|:.:       |
plant   372 MANYSSSLDRRT------------------------EAERTDSSYPKV--GPLRNID-------Y 403

  Fly   385 SPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVV-YNPST 448
            |.|::.|:.|.|..:.::||...|..|                    .|:|:..:.|:| ||.::
plant   404 SSPSSVTSSTQLENNSSTAIGKGSRGA--------------------IIECSRTNMNIVPYNQNS 448

  Fly   449 DTFNETKITLTNLEPVTT------YTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLN 507
            :  .:.|....:|.|...      |......:|:|...::.|                      |
plant   449 E--EDPKNLFADLNPFQNKGADKLYMPTKSGLNNVDDFHQQK----------------------N 489

  Fly   508 IPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKV 572
            .||                               :....|.:.|..          |.....||
plant   490 NPL-------------------------------VGRSPAPMMWKN----------YSCNEAPK- 512

  Fly   573 ELDAINKSALNTKETKAHIVGLL----ENTEYG-FQVRCKTNNGFGSYSNMIYAQTLQSVGSVYD 632
                        ::..::|..||    .:..|| .|....|::..|:.|:.::.:.
plant   513 ------------RKENSYIENLLPKLHRDPRYGNTQSSYATSSSNGAISSNVHGRD--------- 556

  Fly   633 DSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLP---------------- 681
               .:.|::...|..      ...:|....|....:|:::.:.|.|.|.
plant   557 ---NVTFVSPVAVPS------SFTSTENQFRPSIVEDMNRNTNNELDLQPHTAAVVHGQQNDESH 612

  Fly   682 ----LDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSY-VDPHTYEDPNQAIREFAREIDANYI 741
                ..|.|::: |....|.:|. |.:.::.|  :|.|| .||...:|.:  :.|.  ||..|.:
plant   613 IHDHRKYTSDDI-STGCDPRLKD-HESTSSSL--DSTSYRNDPQVLDDAD--VGEC--EIPWNDL 669

  Fly   742 TIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKT-LKPGSSEKARCDFLTEASIMGQFDHPNVI 805
            .|...||.|.:|:|.....       ...:||:|. |....|..|..:|.:|..||.:..||||:
plant   670 VIAERIGLGSYGEVYHADW-------HGTEVAVKKFLDQDFSGAALAEFRSEVRIMRRLRHPNVV 727

  Fly   806 YLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYL--SDMNYVHRD 868
            :..|.|||...:.|:||::..|||...|..........:.|.|...:|.||:.|  |....||||
plant   728 FFLGAVTRPPNLSIVTEFLPRGSLYRILHRPKSHIDERRRIKMALDVAMGMNCLHTSTPTIVHRD 792

  Fly   869 LAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGV 933
            |...|:||:.....|:.||||||...|...:..:..|  ...|.|||.:.........||:|:||
plant   793 LKTPNLLVDNNWNVKVGDFGLSRLKHNTFLSSKSTAG--TPEWMAPEVLRNEPSNEKCDVYSFGV 855

  Fly   934 VLWEVMSYGERPYWNWSN-QDVIKSIEKGY---RLPAPMDCPEALYQLMLDCWQKQRTHRPTFAS 994
            :|||:.:.  |..|...| ..|:.::  |:   ||..|.:....:.:::|:|||.....||:||.
plant   856 ILWELATL--RLPWRGMNPMQVVGAV--GFQNRRLEIPKELDPVVGRIILECWQTDPNLRPSFAQ 916

  Fly   995 IVSTLDNLARQPQSLLTTRPSPE 1017
            :...|..|.|      ...|:|:
plant   917 LTEVLKPLNR------LVLPTPQ 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	15/60 (25%)
		FN3	387..476	CDD:238020	18/95 (19%)
		FN3	536..623	CDD:238020	14/91 (15%)
		EphA2_TM	644..736	CDD:291255	21/112 (19%)
		PTKc_EphR	736..1002	CDD:270629	86/272 (32%)
		Pkinase_Tyr	741..999	CDD:285015	83/264 (31%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
EDR1	NP_563824.1	EDR1	129..327	CDD:291079	14/49 (29%)
		Pkinase_Tyr	669..921	CDD:285015	83/264 (31%)
		STKc_MAP3K-like	675..921	CDD:270901	82/258 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910