DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT5G58300

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001119458.1	Gene:	AT5G58300 / 835942	AraportID:	AT5G58300	Length:	654	Species:	Arabidopsis thaliana

Alignment Length:	608	Identity:	132/608 - (21%)
Similarity:	231/608 - (37%)	Gaps:	136/608 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 NLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVF 524
            ||.|      .||::.|:.:|  :.:|:|.|..|.    .|.:..|..:.|..|.. ||:....|
plant   127 NLPP------DIHSLPSLDYI--YLQHNNFSGEVP----SFVSRQLNILDLSFNSF-TGKIPATF 178

  Fly   525 TTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKA 589
                   ..:..|..|::.|.    :...||.:                ||.::...||....
plant   179 -------QNLKQLTGLSLQNN----KLSGPVPN----------------LDTVSLRRLNLSNN-- 214

  Fly   590 HIVGLLENTEYGFQVR---------------CKTNNGFGSYSNMIYAQTL----QSVGS--VYDD 633
            |:.|.:.:...||...               |.|::...|.:..|....|    ...||  ....
plant   215 HLNGSIPSALGGFPSSSFSGNTLLCGLPLQPCATSSPPPSLTPHISTPPLPPFPHKEGSKRKLHV 279

  Fly   634 SVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIV 698
            |..|...||.... :|.:.:.|:......:.|.:|.:.|..|     ..:.|..|..|....|..
plant   280 STIIPIAAGGAAL-LLLITVIILCCCIKKKDKREDSIVKVKT-----LTEKAKQEFGSGVQEPEK 338

  Fly   699 KKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIP 763
            .||       :|.|..||  ....||..:|..|              ::|.|.:|...:..|:
plant   339 NKL-------VFFNGCSY--NFDLEDLLRASAE--------------VLGKGSYGTAYKAVLE-- 378

  Fly   764 PNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQF-DHPNVIYLQGVVTRSNPVMIITEYMENG 827
                :...|.:|.||..::.|.  :|..:..|:.:. :||:|:.|:......:..:::.:|...|
plant   379 ----ESTTVVVKRLKEVAAGKR--EFEQQMEIISRVGNHPSVVPLRAYYYSKDEKLMVCDYYPAG 437

  Fly   828 SLDTFLRVNDGKFQTL----QLIVMLRGIASGMSYL---SDMNYVHRDLAARNVLVNAQLICKIA 885
            :|.:.|..|.|..:|.    ..:.:....|.|:::|   ....:.|.::.:.||::..:....|:
plant   438 NLSSLLHGNRGSEKTPLDWDSRVKITLSAAKGIAHLHAAGGPKFSHGNIKSSNVIMKQESDACIS 502

  Fly   886 DFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWS 950
            ||||:..:  |......||    ..:.|||.:..||.|..|||:|:||::.|::: |:.|..:.|
plant   503 DFGLTPLM--AVPIAPMRG----AGYRAPEVMETRKHTHKSDVYSFGVLILEMLT-GKSPVQSPS 560

  Fly   951 NQDV------IKSIEK--------GYRLPAPMDCPEALYQLM---LDCWQKQRTHRPTFASIVST 998
            ..|:      ::|:.:        ...|....:..|.:.|::   :.|..:....|||...:|..
plant   561 RDDMVDLPRWVQSVVREEWTSEVFDIELMRFQNIEEEMVQMLQIAMACVAQVPEVRPTMDDVVRM 625

  Fly   999 LDNLARQPQSLLTTRPSPESDGN 1021
            ::.:......  |||||  ||.|
plant   626 IEEIRVSDSE--TTRPS--SDDN 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	5/15 (33%)
		FN3	536..623	CDD:238020	17/101 (17%)
		EphA2_TM	644..736	CDD:291255	20/91 (22%)
		PTKc_EphR	736..1002	CDD:270629	62/290 (21%)
		Pkinase_Tyr	741..999	CDD:285015	62/282 (22%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT5G58300	NP_001119458.1	LRRNT_2	45..83	CDD:285463
		LRR_8	<103..148	CDD:290566	8/28 (29%)
		LRR_RI	<113..>224	CDD:238064	29/138 (21%)
		leucine-rich repeat	114..137	CDD:275380	5/15 (33%)
		leucine-rich repeat	138..159	CDD:275380	6/26 (23%)
		LRR_8	158..216	CDD:290566	15/87 (17%)
		leucine-rich repeat	160..183	CDD:275380	6/30 (20%)
		leucine-rich repeat	184..205	CDD:275380	7/40 (18%)
		leucine-rich repeat	206..229	CDD:275380	6/24 (25%)
		Pkinase	362..625	CDD:278497	63/291 (22%)
		STKc_IRAK	364..629	CDD:270968	62/279 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050