DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT5G49780

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001332720.1	Gene:	AT5G49780 / 835041	AraportID:	AT5G49780	Length:	978	Species:	Arabidopsis thaliana

Alignment Length:	739	Identity:	166/739 - (22%)
Similarity:	276/739 - (37%)	Gaps:	220/739 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 NYTNKTCTECPLGTFKSP----------EVTKCTPCPPNSNASK----TGSPFCKCASGFYRHPN 376
            |:.|:|   ...||.||.          ::|:....|.|..:|:    ..:|.|         |.
plant   349 NWLNET---LDFGTNKSQNLDFVDLQYNDITEYIKQPANKGSSRIVILANNPVC---------PE 401

  Fly   377 DGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPN 441
            .|.          |.|...:.|:.            |.|:||..|:            |..||..
plant   402 VGN----------PPNEYCIEVEH------------NSSYSSPKNT------------CGRCSGE 432

  Fly   442 VVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHIN--EFKRHSNESSLVAVSDIVFSNTS 504
                              :.||:.|....::.|.......  .|..:||             |.:
plant   433 ------------------DREPIPTTCRCVYPITGTLTFRSPSFSGYSN-------------NDT 466

  Fly   505 LLNIPLDLNEVKTGQAE-IVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRW 568
            ..|:.|:|    ||..| ..:|.:||   .:.|:|      :|.|   |..:..|..|
plant   467 FENLRLNL----TGFFENRNYTVDSV---AIRNIR------EDED---DHYLLIDLSL------- 508

  Fly   569 FPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDD 633
            || .:.|..|::.:::      ::.......|      |..|.||.|              ::..
plant   509 FP-YKQDRFNETGMDS------VISRFSTQTY------KPPNTFGPY--------------IFKA 546

  Fly   634 SVQIRF---------IAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEV 689
            :...:|         |.||:|...:||:|.:||.:|.::.|.:.:......|      .:..:.:
plant   547 NKYNKFPAGGSNSSHIIGAVVGSTVFLLILMIAGIYALKQKRRAEKANDQIN------PFGKDVL 605

  Fly   690 NSMDTTPIVKKLHLNVTTPLFGNSRSYVDPH-------TYEDPNQAIREFAREIDANYITIEAII 747
            .|..|..|:....|.||.....|..|...|.       |:|:..:.         ||..::...:
plant   606 LSGKTDKILIAFFLYVTAKWDANQNSVDAPQLMGTKAFTFEEMRKC---------ANNFSVANDV 661

  Fly   748 GGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVT 812
            |||.:|.|.:|.|  |...:    :|||..:|||.:.| .:|.||..::.:..|.||:.|.|...
plant   662 GGGGYGQVYKGIL--PSGQL----IAIKRAQPGSLQGA-LEFKTEIELLSRVHHKNVVKLLGFCF 719

  Fly   813 RSNPVMIITEYMENGSLDTFLRVNDG-KFQTLQLIVMLRGIASGMSY---LSDMNYVHRDLAARN 873
            .....|::.||:.||||...|....| :....:.:.:..|...|::|   |:|...:|||:.:.|
plant   720 DRGEQMLVYEYIPNGSLRDSLSGKSGIRLDWTRRLRIALGSGKGLAYLHELADPPIIHRDVKSSN 784

  Fly   874 VLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEV 938
            ||::..|..|:||||||:.:|:|..|..|...|..:.:..||.....:.|..|||:.:||::.|:
plant   785 VLLDESLTAKVADFGLSQLVEDAEKANVTAQVKGTMGYLDPEYYMTNQLTEKSDVYGFGVMMLEL 849

  Fly   939 MSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLM------------------------- 978
            :: |:.|..|  .:.|:|.::      ..|:..:.||.|.
plant   850 LT-GKIPIEN--GKYVVKEMK------MKMNKSKNLYDLQDFLDTTISATSNRNLKGFEKYVDVA 905

  Fly   979 LDCWQKQRTHRPTFASIVSTLDNL 1002
            |.|...:...||:...:|..::|:
plant   906 LRCVDPEGVKRPSMNEVVKEIENI 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	15/88 (17%)
		FN3	536..623	CDD:238020	17/86 (20%)
		EphA2_TM	644..736	CDD:291255	20/98 (20%)
		PTKc_EphR	736..1002	CDD:270629	81/294 (28%)
		Pkinase_Tyr	741..999	CDD:285015	79/286 (28%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT5G49780	NP_001332720.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960