DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and AT5G49760

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_199787.2	Gene:	AT5G49760 / 835039	AraportID:	AT5G49760	Length:	953	Species:	Arabidopsis thaliana

Alignment Length:	699	Identity:	156/699 - (22%)
Similarity:	275/699 - (39%)	Gaps:	181/699 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 YSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVV--YNP 446
            :|||...|           .|:..::..::..|.::.:|::...|:.|         |.:  |.|
plant   335 FSPPQLQT-----------VILKRNSIVESLDFGTDVSSQLEFVDLQY---------NEITDYKP 379

  Fly   447 STDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLD 511
            |.:  ...::.|.| .||.     :.|.|..|:.:..:.                |||...:|.:
plant   380 SAN--KVLQVILAN-NPVC-----LEAGNGPSYCSAIQH----------------NTSFSTLPTN 420

  Fly   512 LNEVKTG-------------QAEIVFTTESVLLSTVFNLRILAITNK---DADLEWDKPVQS--- 557
            .:..:.|             ...:.|.:.|  .|.:||....:|..|   |...:::.||.|
plant   421 CSPCEPGMEASPTCRCAYPFMGTLYFRSPS--FSGLFNSTNFSILQKAIADFFKKFNYPVDSVGV 483

  Fly   558 ----DFPLE---FYEVRWFPKVELDAINKSALNTKETKAHIVGL-LENTEYGFQVRCKTNNGFGS 614
                :.|.:   ..::..||      :.:.:.|  :|...:||. ..|..|      |....||.
plant   484 RNIRENPTDHQLLIDLLVFP------LGRESFN--QTGMSLVGFAFSNQTY------KPPPIFGP 534

  Fly   615 YSNMIYAQTLQSVGS---VYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTN 676
            |   |:...|....|   |...|.....:.||:|..|:.|::..||.:|.:|.|.:.:   ::|.
plant   535 Y---IFKADLYKQFSDVEVSSKSSNKSILIGAVVGVVVLLLLLTIAGIYALRQKKRAE---RATG 593

  Fly   677 HLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYI 741
            .        :|.....||:      ..::..|....::::    |:|:..:....|:...|
plant   594 Q--------NNPFAKWDTS------KSSIDAPQLMGAKAF----TFEELKKCTDNFSEAND---- 636

  Fly   742 TIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIY 806
                 :|||.:|.|.||   |.||...   :|||..:.||.: ...:|.||..::.:..|.||:.
plant   637 -----VGGGGYGKVYRG---ILPNGQL---IAIKRAQQGSLQ-GGLEFKTEIELLSRVHHKNVVR 689

  Fly   807 LQGVVTRSNPVMIITEYMENGSLDTFLRVNDG-KFQTLQLIVMLRGIASGMSY---LSDMNYVHR 867
            |.|.....|..|::.||:.||||...|....| :....:.:.:..|...|::|   |:|...:||
plant   690 LLGFCFDRNEQMLVYEYISNGSLKDSLSGKSGIRLDWTRRLKIALGSGKGLAYLHELADPPIIHR 754

  Fly   868 DLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYG 932
            |:.:.|:|::..|..|:||||||:.:.:....:.|...|..:.:..||.....:.|..|||:.:|
plant   755 DIKSNNILLDENLTAKVADFGLSKLVGDPEKTHVTTQVKGTMGYLDPEYYMTNQLTEKSDVYGFG 819

  Fly   933 VVLWEVMSYGERPYWNWSNQDVIKSIEKG----YRLPAPMDCPEALYQL--MLD----------- 980
            |||.|::: |..|            ||:|    ..:...|:...:||.|  :||
plant   820 VVLLELLT-GRSP------------IERGKYVVREVKTKMNKSRSLYDLQELLDTTIIASSGNLK 871

  Fly   981 -----------CWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPES 1018
                       |.:::..:||:...:|..::|:    ..|....|:.:|
plant   872 GFEKYVDLALRCVEEEGVNRPSMGEVVKEIENI----MQLAGLNPNSDS 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	16/90 (18%)
		FN3	536..623	CDD:238020	21/100 (21%)
		EphA2_TM	644..736	CDD:291255	16/91 (18%)
		PTKc_EphR	736..1002	CDD:270629	80/297 (27%)
		Pkinase_Tyr	741..999	CDD:285015	79/289 (27%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT5G49760	NP_199787.2	PLN00113	69..903	CDD:215061	152/680 (22%)
		leucine-rich repeat	71..90	CDD:275380
		leucine-rich repeat	91..115	CDD:275380
		leucine-rich repeat	116..139	CDD:275380
		leucine-rich repeat	140..163	CDD:275380
		leucine-rich repeat	164..188	CDD:275380
		leucine-rich repeat	189..219	CDD:275380
		leucine-rich repeat	220..243	CDD:275380
		leucine-rich repeat	244..267	CDD:275380
		leucine-rich repeat	268..290	CDD:275380
		leucine-rich repeat	291..315	CDD:275380
		leucine-rich repeat	316..334	CDD:275380
		leucine-rich repeat	340..363	CDD:275380	3/33 (9%)
		STKc_IRAK	649..904	CDD:270968	72/271 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050