DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT5G45780

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_199390.2	Gene:	AT5G45780 / 834618	AraportID:	AT5G45780	Length:	614	Species:	Arabidopsis thaliana

Alignment Length:	484	Identity:	123/484 - (25%)
Similarity:	198/484 - (40%)	Gaps:	120/484 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   640 IAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHL--PLP----LDY-----------ASN 687
            :||  ::|:.||                 ||   |.|:|  |.|    .||           ||.
plant   171 VAG--LSGLSFL-----------------DL---SFNNLSGPTPNISAKDYRIVGNAFLCGPASQ 213

  Fly   688 EVNSMDTTPI----------VKKLHLNVTTPLFG----------------------NSRSYVDPH 720
            |:.| |.||:          ..|.|..|.:..||                      .|||:|. .
plant   214 ELCS-DATPVRNATGLSEKDNSKHHSLVLSFAFGIVVAFIISLMFLFFWVLWHRSRLSRSHVQ-Q 276

  Fly   721 TYEDPNQAIREFA-REID---ANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGS 781
            .||.....::.|: |||.   :|: :.:.|:|.|.||.|.:|.|   ||   ...||:|.|| ..
plant   277 DYEFEIGHLKRFSFREIQTATSNF-SPKNILGQGGFGMVYKGYL---PN---GTVVAVKRLK-DP 333

  Fly   782 SEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTL--- 843
            .......|.||..::|...|.|::.|.|........|::..||.|||:...||.|.|:..:|
plant   334 IYTGEVQFQTEVEMIGLAVHRNLLRLFGFCMTPEERMLVYPYMPNGSVADRLRDNYGEKPSLDWN 398

  Fly   844 QLIVMLRGIASGMSYLSDM---NYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGG 905
            :.|.:..|.|.|:.||.:.   ..:|||:.|.|:|::......:.||||::.::. .|::.|...
plant   399 RRISIALGAARGLVYLHEQCNPKIIHRDVKAANILLDESFEAIVGDFGLAKLLDQ-RDSHVTTAV 462

  Fly   906 KIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSI----------EK 960
            :..:...|||.::..:.:..:||:.:||::.|::: |.:.. :..|..|.|.:          ||
plant   463 RGTIGHIAPEYLSTGQSSEKTDVFGFGVLILELIT-GHKMI-DQGNGQVRKGMILSWVRTLKAEK 525

  Fly   961 GYRLPAPMDCP--------EALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPE 1017
            .:......|..        |.:.:|.|.|.|.....||..:.::..|:.|..|.:.....| :|.
plant   526 RFAEMVDRDLKGEFDDLVLEEVVELALLCTQPHPNLRPRMSQVLKVLEGLVEQCEGGYEAR-APS 589

  Fly  1018 SDGNHILDGQRGQNIFISTDLWLEHIKMS 1046
            ...|: .:|...|:..|      |.|::|
plant   590 VSRNY-SNGHEEQSFII------EAIELS 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020
		FN3	536..623	CDD:238020
		EphA2_TM	644..736	CDD:291255	32/141 (23%)
		PTKc_EphR	736..1002	CDD:270629	77/292 (26%)
		Pkinase_Tyr	741..999	CDD:285015	74/281 (26%)
		SAM_1	1033..1092	CDD:278937	4/14 (29%)
		SAM	1039..1092	CDD:197735	3/8 (38%)
AT5G45780	NP_199390.2	PLN00113	39..>192	CDD:215061	11/42 (26%)
		leucine-rich repeat	129..152	CDD:275380
		leucine-rich repeat	153..176	CDD:275380	2/6 (33%)
		PKc_like	306..574	CDD:419665	74/277 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050