DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT5G37450

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001332712.1	Gene:	AT5G37450 / 833722	AraportID:	AT5G37450	Length:	983	Species:	Arabidopsis thaliana

Alignment Length:	767	Identity:	168/767 - (21%)
Similarity:	292/767 - (38%)	Gaps:	214/767 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 PAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNI-------------- 437
            |....:|.|.::|.:|..::...| ||:..::.|...:|::.:...|..|.
plant   263 PDLSKSLVLYYLDISSNKLTGEIP-KNKFSANITTINLYNNLLSGSIPSNFSGLPRLQRLQVQNN 326

  Fly   438 ----------------CSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRH 486
                            ....::.:...:.|:.....|.|  |.:..||:::.....:::|..|.
plant   327 NLSGEIPVIWENRILKAEEKLILDLRNNMFSNVSSVLLN--PPSNVTVKLYGNPVCANVNAGKL- 388

  Fly   487 SNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTV--FNLRILAITNKDADL 549
               :.|..:|.:...:.:..:..:...:.|.....:....:.|:.|.|  |....|.|     ||
plant   389 ---ADLCGISTLEVESPATSSETISTGDCKRQSCPVSENYDYVIGSPVACFCAAPLGI-----DL 445

  Fly   550 EWDKPVQSDF----------------------------------PLEFYEVRWFPKVELDAINKS 580
            ....|..|||                                  |..|..::.||:.       |
plant   446 RLRSPSFSDFRPYKVSYMLDVASPKNLGINPYQISIDTFAWQSGPRLFMNMKIFPEY-------S 503

  Fly   581 ALNTKETKAHIVGLLE-------NTEYG---FQV------RCKTNNGFGSYSNMIYAQTLQSVGS 629
            .||:|.....:..:::       ||:..   :::      ..|..|....||::...:....|..
plant   504 ELNSKFNSTEVQRIVDFFATFTLNTDDSLGPYEIISINTGAYKDGNTHIFYSSLCIKRVFIYVTP 568

  Fly   630 VYDDS------------VQIRFIAGAIVTGVLFLVIFIIATVYFM-RSKHQ---DDLDKKSTNHL 678
            ||:.:            |.:..|.|||   ..|||:..:|.|:|: |||.:   .::|.:..:.|
plant   569 VYEVTIIFPKKSGMSIGVSVGIIIGAI---AFFLVLSSLALVFFIKRSKRKRKTREVDMEQEHPL 630

  Fly   679 PLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITI 743
            |.|                          |:  |..| |..:.:.:.:.|...|:   |.:.
plant   631 PKP--------------------------PM--NMES-VKGYNFTELDSATSSFS---DLSQ--- 660

  Fly   744 EAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQ 808
               ||.|.:|.|.:|.|  |...|    ||:|..:.||.:..: :|.||..::.:..|.|::.|.
plant   661 ---IGRGGYGKVYKGHL--PGGLV----VAVKRAEQGSLQGQK-EFFTEIELLSRLHHRNLVSLL 715

  Fly   809 GVVTRSNPVMIITEYMENGSLDTFLRVNDGKF-QTLQLIVMLR---GIASGMSYL---SDMNYVH 866
            |...:....|::.|||.||||...|   ..:| |.|.|.:.||   |.|.|:.||   :|...:|
plant   716 GYCDQKGEQMLVYEYMPNGSLQDAL---SARFRQPLSLALRLRIALGSARGILYLHTEADPPIIH 777

  Fly   867 RDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIP-------VRWTA----PEAIAFR 920
            ||:...|:|:::::..|:||||:|:.|  |.|     ||.:.       |:.|.    ||.....
plant   778 RDIKPSNILLDSKMNPKVADFGISKLI--ALD-----GGGVQRDHVTTIVKGTPGYVDPEYYLSH 835

  Fly   921 KFTSASDVWSYGVVLWEVMSYGERPYWNWSN--QDVIKSIEKGYRLPA--------PMDCPEALY 975
            :.|..|||:|.|:|..|::: |.||..:..|  ::|.::.:.|..:..        ..:|.:...
plant   836 RLTEKSDVYSLGIVFLEILT-GMRPISHGRNIVREVNEACDAGMMMSVIDRSMGQYSEECVKRFM 899

  Fly   976 QLMLDCWQKQRTHRPTFASIVSTLDNL------ARQPQSLLTTRPSPESDGN 1021
            :|.:.|.|.....||....||..|:|:      ..:|.|    .||.:|..:
plant   900 ELAIRCCQDNPEARPWMLEIVRELENIYGLIPKEEKPYS----SPSVQSSAS 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	18/118 (15%)
		FN3	536..623	CDD:238020	22/136 (16%)
		EphA2_TM	644..736	CDD:291255	20/95 (21%)
		PTKc_EphR	736..1002	CDD:270629	86/293 (29%)
		Pkinase_Tyr	741..999	CDD:285015	84/285 (29%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT5G37450	NP_001332712.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050