DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT5G16900

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001318574.1	Gene:	AT5G16900 / 831553	AraportID:	AT5G16900	Length:	866	Species:	Arabidopsis thaliana

Alignment Length:	1038	Identity:	194/1038 - (18%)
Similarity:	339/1038 - (32%)	Gaps:	357/1038 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 YIEIQ--FTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIARIAAG-EGRFNQ 218
            |::.|  |...||.| |.|.....|..:.|.:..||                ..|.:| .||..:
plant    17 YVQAQQGFISLDCGL-PSNEPPYIEPVTGLVFSSDA----------------DHIPSGISGRIQK 64

  Fly   219 NSDVDINTEVKSIAVN-KKGVYFAFRDQGA--C--ISVLAVKVYYITCPAVTENFAHFNETPT-- 276
            |.:          ||: |..::..:...|.  |  :.||..:.|.|....|..|:..:|:.|:
plant    65 NLE----------AVHIKPYLFLRYFPDGLRNCYTLDVLQNRRYMIKAVFVYGNYDGYNDYPSFD 119

  Fly   277 --------------GR------EITIIEKQNG--TCV---DNAEPY---------ETPTYLCKGD 307
                          |:      ||..|...|.  .|:   .|:.|:         ...||:.:..
plant   120 LYLGPNKWVRVDLEGKVNGSVEEIIHIPSSNSLQICLVKTGNSLPFISALELRLLRNDTYVVQDV 184

  Fly   308 G---------------------------------KWTILTGGCRCKAGYEPNYTNKTCTECPLGT 339
            .                                 :||.:|      ...:.|.:|         .
plant   185 SLKHLFRRYYRQSDRLIRYPDDVYDRVWSPFFLPEWTQIT------TSLDVNNSN---------N 234

  Fly   340 FKSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTN------LTLLFV 398
            ::.|:....:...|..|.::....:.      ..:|::..|:..:.....|..      |..||
plant   235 YEPPKAALTSAATPGDNGTRLTIIWT------LDNPDEQIHLYVHFAELEPVGENTDEALRTLF- 292

  Fly   399 DQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEP 463
                          ..:|....|.||.:.:.:..:...:.:...|.|.........::..:...|
plant   293 --------------TRTFYFVVNGKISYDESITPLDLAVSTVETVVNKCDGGNCSLQLVRSEASP 343

  Fly   464 VTTYTVQIHAINSVSHINEFK-RHS--NESSLVAVSDIVFS-----------------------N 502
                .|::..:|::......| .||  |...::::..|..:                       |
plant   344 ----GVRVPLVNAMEAFTAIKFPHSETNPDDVISIKVIQATYELSRVDWQGDPCLPQQFLWTGLN 404

  Fly   503 TSLLN-------IPLDLNEVK-TGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDF 559
            .|.:|       |.|||:..| ||:          ::..:.||..|    :..||..:| :....
plant   405 CSYMNMSTSPRIISLDLSSHKLTGK----------IVPDIQNLTQL----QKLDLSNNK-LTGGV 454

  Fly   560 PLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLL-------ENTEYGFQVR---CKT---NNG 611
            |            |..|..||.|....:..::||.:       :|.:..|:..   |.|   |:.
plant   455 P------------EFLANMKSLLFINLSNNNLVGSIPQALLDRKNLKLEFEGNPKLCATGPCNSS 507

  Fly   612 FGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTN 676
            .|:....:.|.                 :|.||...:..||:.|:    |::.:...
plant   508 SGNKETTVIAP-----------------VAAAIAIFIAVLVLIIV----FIKKRPSS-------- 543

  Fly   677 HLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYI 741
                                 ::.||         .||:          |.::....|.|..:.|
plant   544 ---------------------IRALH---------PSRA----------NLSLENKKRRITYSEI 568

  Fly   742 TI-----EAIIGGGEFGDVCRGRLKIPPNFVQDID-VAIKTLKPGSSEKARCDFLTEASIMGQFD 800
            .:     |.:||.|.||.|..|       ::.|.: ||:|.|.|.||:..: :|..|..::.:..
plant   569 LLMTNNFERVIGEGGFGVVYHG-------YLNDSEQVAVKVLSPSSSQGYK-EFKAEVELLLRVH 625

  Fly   801 HPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDG----KFQTLQLIVMLRGIASGMSYLSD 861
            |.|::.|.|.......:.:|.|||.||.|.:.|....|    |::....|.:  ..|.|:.||..
plant   626 HINLVSLVGYCDEQAHLALIYEYMANGDLKSHLSGKHGDCVLKWENRLSIAV--ETALGLEYLHS 688

  Fly   862 ---MNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFT 923
               ...||||:.:.|:|::.....|:|||||||......:::.:.|......:..||.....:.|
plant   689 GCKPLMVHRDVKSMNILLDEHFQAKLADFGLSRSFSVGEESHVSTGVVGTPGYLDPEYYRTYRLT 753

  Fly   924 SASDVWSYGVVLWEVMSYGERPYWNWSNQ-----------------------DVIKSIEKGYRLP 965
            ..|||:|:|:||.|:::  .:|....:|:                       ::|...:.|
plant   754 EKSDVYSFGIVLLEIIT--NQPVLEQANENRHIAERVRTMLTRSDISTIVDPNLIGEYDSG---- 812

  Fly   966 APMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDG-NHILDGQ 1027
               ...:|| :|.:.|.......||..:.:|..|....:.....|.|       | |.::|.:
plant   813 ---SVRKAL-KLAMSCVDPSPVARPDMSHVVQELKQCIKSENLRLRT-------GLNQVIDSK 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	25/110 (23%)
		FN3	387..476	CDD:238020	12/94 (13%)
		FN3	536..623	CDD:238020	21/99 (21%)
		EphA2_TM	644..736	CDD:291255	11/91 (12%)
		PTKc_EphR	736..1002	CDD:270629	77/301 (26%)
		Pkinase_Tyr	741..999	CDD:285015	75/293 (26%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT5G16900	NP_001318574.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050