DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT5G16590

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_197162.1	Gene:	AT5G16590 / 831521	AraportID:	AT5G16590	Length:	625	Species:	Arabidopsis thaliana

Alignment Length:	453	Identity:	107/453 - (23%)
Similarity:	181/453 - (39%)	Gaps:	94/453 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   610 NGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTG--VLFLVIFIIATVYFMRSKHQDDLDK 672
            ||.|:       .|:...|....|.:....|.| ||.|  ||.||:|:|......:.|.:..:..
plant   224 NGTGN-------GTVTPGGKGKSDKLSAGAIVG-IVIGCFVLLLVLFLIVFCLCRKKKKEQVVQS 280

  Fly   673 KSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPH---TYEDPNQAIREFAR 734
            :|....|:|...|:....|.....:|..          |.|.:.|..:   ..:|....::.|..
plant   281 RSIEAAPVPTSSAAVAKESNGPPAVVAN----------GASENGVSKNPAAVSKDLTFFVKSFGE 335

  Fly   735 -EIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLK----PGSSEKARCDFLTEAS 794
             ::|........::|.|.||...:.      :|...:.||:|.|:    |   ||   :|..:..
plant   336 FDLDGLLKASAEVLGKGTFGSSYKA------SFDHGLVVAVKRLRDVVVP---EK---EFREKLQ 388

  Fly   795 IMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDG------KFQTLQLIVMLRGIA 853
            ::|...|.|::.|.......:..:::.|||..|||...|..|.|      .::|...|.:  |.|
plant   389 VLGSISHANLVTLIAYYFSRDEKLVVFEYMSRGSLSALLHGNKGSGRSPLNWETRANIAL--GAA 451

  Fly   854 SGMSYL--SDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEA 916
            ..:|||  .|....|.::.:.|:|::.....|::|:.|:..|...|......|      :.|||.
plant   452 RAISYLHSRDATTSHGNIKSSNILLSESFEAKVSDYCLAPMISPTSTPNRIDG------YRAPEV 510

  Fly   917 IAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLP----------APMDC- 970
            ...||.:..:||:|:||::.|::: |:.|    ::|.:   .|:|..||          :|.|.
plant   511 TDARKISQKADVYSFGVLILELLT-GKSP----THQQL---HEEGVDLPRWVSSITEQQSPSDVF 567

  Fly   971 -PE-------------ALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESD 1019
             ||             .|..:.:.|..:....|||...:...::.::|.|.|     |.|.||
plant   568 DPELTRYQSDSNENMIRLLNIGISCTTQYPDSRPTMPEVTRLIEEVSRSPAS-----PGPLSD 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020
		FN3	536..623	CDD:238020	3/12 (25%)
		EphA2_TM	644..736	CDD:291255	21/97 (22%)
		PTKc_EphR	736..1002	CDD:270629	71/302 (24%)
		Pkinase_Tyr	741..999	CDD:285015	70/294 (24%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT5G16590	NP_197162.1	LRRNT_2	25..60	CDD:400522
		PLN00113	<60..619	CDD:215061	102/440 (23%)
		leucine-rich repeat	89..112	CDD:275380
		leucine-rich repeat	113..136	CDD:275380
		leucine-rich repeat	137..160	CDD:275380
		leucine-rich repeat	161..181	CDD:275380
		leucine-rich repeat	182..205	CDD:275380
		PKc_like	349..612	CDD:419665	70/290 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050