DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and AT5G01950

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001330431.1	Gene:	AT5G01950 / 830683	AraportID:	AT5G01950	Length:	956	Species:	Arabidopsis thaliana

Alignment Length:	779	Identity:	165/779 - (21%)
Similarity:	267/779 - (34%)	Gaps:	296/779 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 NGTCVDNAEPYETPTYLCKGDGK-WTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVTKCTP 350
            ||: :.||..:      |:..|| |..|           ||.:..:..:||.....:|:..:.:|
plant   383 NGS-ISNANLF------CESKGKEWISL-----------PNNSTNSALDCPPLACPTPDFYEYSP 429

  Fly   351 CPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNES 415
            ..|..         |.||                                        ||.:
plant   430 ASPLR---------CFCA----------------------------------------APLR--- 442

  Fly   416 FSSETNSKIYHSDIVYKIKCNICSPNVVY-NPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSH 479
                         |.|::|    ||:..| .|..|.|.|.......:||   |.:.|.:
plant   443 -------------IGYRLK----SPSFSYFPPYIDQFGEYVTDFLQMEP---YQLWIDS------ 481

  Fly   480 INEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITN 544

plant   482 ----------------------------------------------------------------- 481

  Fly   545 KDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNT-KETKA-HIVGLLENTEYGFQVRCK 607
                .:|:|..:    |..| ::.||||     |::...| .|::. .|.|:..:.      |..
plant   482 ----YQWEKGPR----LRMY-LKLFPKV-----NETYTRTFNESEVLRIRGIFASW------RFP 526

  Fly   608 TNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFI---------AGAIVTGVLFLVIFIIATVYFMR 663
            .::.||.|..:.:  |||...|..:.:.:.:.:         |||:||.|  .:..::|.:...|
plant   527 GSDLFGPYELLNF--TLQGPYSYVNFNSERKGVSWRRLAAITAGAVVTAV--AISAVVAALLLRR 587

  Fly   664 -SKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQ 727
             |||:.::.::.::.                     |...||          |.:...::::..:
plant   588 YSKHEREISRRRSSS---------------------KASLLN----------SGIRGFSFKELAE 621

  Fly   728 AIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTE 792
            |..:|:.         ..::|.|.:|.|.||.|.  .|.|    .|||....||.:..: :||.|
plant   622 ATDDFSS---------STLVGRGGYGKVYRGVLS--DNTV----AAIKRADEGSLQGEK-EFLNE 670

  Fly   793 ASIMGQFDHPNVIYLQGVVTRS-----NPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLR-- 850
            ..::.:..|.|::.|.|.....     |..|::.|:|.||:|..:|... || ::|...:.:|
plant   671 IELLSRLHHRNLVSLIGYCDEESEQLLNLQMLVYEFMSNGTLRDWLSAK-GK-ESLSFGMRIRVA 733

  Fly   851 -GIASGMSYL-SDMN--YVHRDLAARNVLVNAQLICKIADFGLSR---EIENASDAYTTRGGKIP 908
             |.|.|:.|| ::.|  ..|||:.|.|:|::.....|:|||||||   .:|:..|        :|
plant   734 LGAAKGILYLHTEANPPVFHRDIKASNILLDPNFNAKVADFGLSRLAPVLEDEED--------VP 790

  Fly   909 ------VRWTA----PEAIAFRKFTSASDVWSYGVVLWEVM------SYGE---RPYWNWSNQDV 954
                  ||.|.    ||.....|.|..|||:|.|||..|::      |:|:   |.......:|:
plant   791 KHVSTVVRGTPGYLDPEYFLTHKLTDKSDVYSIGVVFLELLTGMHAISHGKNIVREVKTAEQRDM 855

  Fly   955 IKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPES 1018
            :.|:......|..|:..|....|.|.|.......||..|.:|..|       :|||...|..|:
plant   856 MVSLIDKRMEPWSMESVEKFAALALRCSHDSPEMRPGMAEVVKEL-------ESLLQASPDRET 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	16/89 (18%)
		FN3	536..623	CDD:238020	17/88 (19%)
		EphA2_TM	644..736	CDD:291255	14/92 (15%)
		PTKc_EphR	736..1002	CDD:270629	87/298 (29%)
		Pkinase_Tyr	741..999	CDD:285015	86/290 (30%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT5G01950	NP_001330431.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050