DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and SRF2

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_196300.1	Gene:	SRF2 / 830573	AraportID:	AT5G06820	Length:	735	Species:	Arabidopsis thaliana

Alignment Length:	696	Identity:	134/696 - (19%)
Similarity:	241/696 - (34%)	Gaps:	198/696 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 DIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSL 492
            :|.:.:..|....|:.||..|.:...:...:|:|:.:           ::||          :||
plant   110 EIPFGLPPNATHINMAYNNLTQSIPFSLPLMTSLQSL-----------NLSH----------NSL 153

  Fly   493 VAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNK------------ 545
            ......|||...:..:.|..|.: ||.....|       .|:.||..|.:.|.
plant   154 SGPLGNVFSGLQIKEMDLSFNNL-TGDLPSSF-------GTLMNLTSLYLQNNRLTGSVIYLADL 210

  Fly   546 ---DADLE--------------------WD---------KPVQSDFPLEFYEVR-------WFPK 571
               |.::|                    |.         ||.:  |||   :||       .:|.
plant   211 PLADLNIEDNQFSGIIPSHFQSIPHLWIWGNKFHVEPNYKPWK--FPL---DVRPLIQNDTGYPT 270

  Fly   572 VELDAI-NKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSV 635
            .|..|| |.....|::.|                  |...|.|:.|..:
plant   271 TESSAIMNFPRPETQKVK------------------KKKKGIGAGSTFL---------------- 301

  Fly   636 QIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLD----KKSTNHL--PLPLDYASNEVNSMDT 694
               .:.|..:.|..|       .::.:|..|:...:    .:|.|.:  .||:........:.:.
plant   302 ---LVGGLALLGTFF-------ALFAVRMNHRRAQNLAAIHRSNNSIAYSLPVSTGREYPVATED 356

  Fly   695 TPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAR----------------EIDANYITI 743
            .|.:|:..    .|.....|....|....|.:...:.|:.                ::..|..:.
plant   357 NPQIKRFQ----PPPAPQLRHLPSPPVRIDKSARRKSFSATCQYPSFAKLFSAAELQLATNCFSE 417

  Fly   744 EAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSS-----EKARCDFLTEASIMGQFDHPN 803
            |.::|.|..|.|.|.:|       .|...|:....|.||     |:...:.|..||   :..|||
plant   418 ENLLGEGPLGSVYRAKL-------PDGQFAVVRNIPMSSLSLHEEEQFTEVLQTAS---KLRHPN 472

  Fly   804 VIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLR---GIASGMSYLSDM--- 862
            ::.|.|....:...:::.||:  |.|..:..::|..::.|...:.||   |:|..:.||...
plant   473 IVTLLGFCIENGEHLLVYEYV--GHLSLYNAMHDEVYKPLSWGLRLRIAIGVARALDYLHSSFCP 535

  Fly   863 NYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVR---WTAPEAIAFRKFTS 924
            ...|.||.|.|:|::.:|..:|||.||:......|::...|..:|.::   :.|||........:
plant   536 PIAHSDLKATNILLDEELTPRIADCGLASLRPLTSNSVKLRASEIAIQNTGYIAPEHGQPGSSGT 600

  Fly   925 ASDVWSYGVVLWEVMS----------YGERPYWNWSN------QDVIKSIEKGYRLPAPMDCPEA 973
            .||.::.||:|.|:::          .||:....|::      :.:.:.|:.|............
plant   601 KSDTYALGVLLLELLTGRKAFDSSRPRGEQLLVKWASTRLHDRRSLEQMIDGGIAGTFSSRVASQ 665

  Fly   974 LYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESD 1019
            ...::..|.|.::..||..:.||..|..|.::.....::..:.::|
plant   666 YADIISLCTQAEKEFRPPVSEIVEALTALIQKQNKEASSSVADKTD 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	8/47 (17%)
		FN3	536..623	CDD:238020	25/138 (18%)
		EphA2_TM	644..736	CDD:291255	15/113 (13%)
		PTKc_EphR	736..1002	CDD:270629	70/295 (24%)
		Pkinase_Tyr	741..999	CDD:285015	68/287 (24%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
SRF2	NP_196300.1	LRRNT_2	31..69	CDD:285463
		leucine-rich repeat	67..86	CDD:275380
		leucine-rich repeat	97..118	CDD:275380	1/7 (14%)
		LRR_8	117..176	CDD:290566	16/79 (20%)
		leucine-rich repeat	119..142	CDD:275380	4/22 (18%)
		leucine-rich repeat	143..165	CDD:275380	8/42 (19%)
		LRR_8	165..222	CDD:290566	12/64 (19%)
		leucine-rich repeat	166..189	CDD:275380	6/30 (20%)
		leucine-rich repeat	190..210	CDD:275380	3/19 (16%)
		leucine-rich repeat	212..235	CDD:275380	2/22 (9%)
		PKc_like	421..694	CDD:304357	68/284 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050