DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and BAK1

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001190904.1	Gene:	BAK1 / 829480	AraportID:	AT4G33430	Length:	662	Species:	Arabidopsis thaliana

Alignment Length:	707	Identity:	146/707 - (20%)
Similarity:	269/707 - (38%)	Gaps:	177/707 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 MPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYN 445
            :||:        ..|:.|  ...::..|..|:.::.|:..||....:.::......:.:|...::
plant     7 IPCF--------FWLILV--LDLVLRVSGNAEGDALSALKNSLADPNKVLQSWDATLVTPCTWFH 61

  Fly   446 PSTDTFNE-TKITLTNLEPVTTYTVQIHAINSVSHINEFKRH---------SNESSLVAVSDIVF 500
            .:.::.|. |::.|.|........:|:..:.::.::..:..:         .|.:.||:: |:..
plant    62 VTCNSDNSVTRVDLGNANLSGQLVMQLGQLPNLQYLELYSNNITGTIPEQLGNLTELVSL-DLYL 125

  Fly   501 SNTSLLNIPLDLNEVKTGQAEIVFTTESV----------LLSTVFNLRILAITNKDADLEWDKPV 555
            :|.| ..||..|..:|    ::.|.::.|          |...||:.|:      ...:.|...:
plant   126 NNLS-GPIPSTLGRLK----KLRFLSQKVVSPNRCYVILLDEKVFSWRL------GCCIIWSILI 179

  Fly   556 QSDFPLEFYEVRWFPKVELDAI----NKSALN-------TKETKAHIVGLLENTEYGFQVRCKTN 609
            .|           |.|...::|    |.::|:       |......::.|..|...|   ....|
plant   180 MS-----------FRKRNQNSILVRLNNNSLSGEIPRSLTAVLTLQVLDLSNNPLTG---DIPVN 230

  Fly   610 NGFGSYSNMIYAQTLQS---------VGSVYDDSVQIRFIAGAIVTGV-----LFLVIFIIATVY 660
            ..|..::.:.:|.|..:         :............|.|||..||     |...:..||..:
plant   231 GSFSLFTPISFANTKLTPLPASPPPPISPTPPSPAGSNRITGAIAGGVAAGAALLFAVPAIALAW 295

  Fly   661 FMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDP 725
            :.|.|.||                                              .:.|....|||
plant   296 WRRKKPQD----------------------------------------------HFFDVPAEEDP 314

  Fly   726 NQAIREFAR------EIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEK 784
            ...:.:..|      ::.::..:.:.|:|.|.||.|.:|||      .....||:|.||...::.
plant   315 EVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGRL------ADGTLVAVKRLKEERTQG 373

  Fly   785 ARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLR--------VNDGKFQ 841
            ....|.||..::....|.|::.|:|........:::..||.|||:.:.||        ::..|.|
plant   374 GELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQ 438

  Fly   842 TLQLIVMLRGIASGMSYL---SDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTR 903
            .:.|     |.|.|::||   .|...:|||:.|.|:|::.:....:.||||:: :.:..|.:.|.
plant   439 RIAL-----GSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAK-LMDYKDTHVTT 497

  Fly   904 GGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPY--WNWSNQ------DVIKSIEK 960
            ..:..:...|||.::..|.:..:||:.|||:|.|::: |:|.:  ...:|.      |.:|.:.|
plant   498 AVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELIT-GQRAFDLARLANDDDVMLLDWVKGLLK 561

  Fly   961 GYRLPAPMDCP----------EALYQLMLDCWQKQRTHRPTFASIVSTL--DNLARQ 1005
            ..:|.|.:|..          |.|.|:.|.|.|.....||..:.:|..|  |.||.:
plant   562 EKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVVRMLEGDGLAER 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	13/89 (15%)
		FN3	536..623	CDD:238020	15/97 (15%)
		EphA2_TM	644..736	CDD:291255	15/102 (15%)
		PTKc_EphR	736..1002	CDD:270629	80/296 (27%)
		Pkinase_Tyr	741..999	CDD:285015	78/286 (27%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
BAK1	NP_001190904.1	LRRNT_2	26..65	CDD:285463	5/38 (13%)
		leucine-rich repeat	94..117	CDD:275380	1/22 (5%)
		leucine-rich repeat	118..141	CDD:275380	9/28 (32%)
		leucine-rich repeat	142..187	CDD:275380	10/61 (16%)
		leucine-rich repeat	188..211	CDD:275380	4/22 (18%)
		TyrKc	337..610	CDD:197581	78/285 (27%)
		STK_BAK1_like	342..613	CDD:271134	78/283 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050