DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and AT4G23740

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001328543.1	Gene:	AT4G23740 / 828474	AraportID:	AT4G23740	Length:	638	Species:	Arabidopsis thaliana

Alignment Length:	725	Identity:	134/725 - (18%)
Similarity:	255/725 - (35%)	Gaps:	239/725 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 KIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKIT---LTNLEPVTTY----TVQIHAI------ 474
            :||    ::.:..::|.  ::|..::|...:.:..   ||.::|..:.    |.|:..|
plant     5 RIY----LWSLCLSLCL--IIYGANSDPLEDKRALLEFLTIMQPTRSLNWNETSQVCNIWTGVTC 63

  Fly   475 -----------------------NSVSHINEFKRHSNESSLVA---------VSDIVF------- 500
                                   |::|.::..:..|..|:|::         :.|:.|
plant    64 NQDGSRIIAVRLPGVGLNGQIPPNTISRLSALRVLSLRSNLISGEFPKDFVELKDLAFLYLQDNN 128

  Fly   501 ---------------SNTSLLN------IPLDLNEVKTGQ----AEIVFTTESVLLSTVFNLRIL 540
                           ::.:|.|      ||..|:.:|..|    |....:.:...||.:.:|:.:
plant   129 LSGPLPLDFSVWKNLTSVNLSNNGFNGTIPSSLSRLKRIQSLNLANNTLSGDIPDLSVLSSLQHI 193

  Fly   541 AITNKDADL-----EWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNT-------------KET 587
            .::| :.||     :|.:    .||...|       ..:|.|......|             |.:
plant   194 DLSN-NYDLAGPIPDWLR----RFPFSSY-------TGIDIIPPGGNYTLVTPPPPSEQTHQKPS 246

  Fly   588 KAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLV 652
            ||..:||.|..                                    ..:..||.:||  |:..:
plant   247 KARFLGLSETV------------------------------------FLLIVIAVSIV--VITAL 273

  Fly   653 IFIIATVYFMRSKHQDD-------LDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLH-LNVTTPL 709
            .|::...|..|...:.|       |.||                ..|.....|.::. :|
plant   274 AFVLTVCYVRRKLRRGDGVISDNKLQKK----------------GGMSPEKFVSRMEDVN----- 317

  Fly   710 FGNSRSYVDPHTYE-DPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVA 773
              |..|:.:...|. |....:|..|.           ::|.|.||...:..|:      ....||
plant   318 --NRLSFFEGCNYSFDLEDLLRASAE-----------VLGKGTFGTTYKAVLE------DATSVA 363

  Fly   774 IKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDG 838
            :|.||..::.|.  ||..:..|:|...|.||:.|:......:..:::.:|...||:.:.|..|.|
plant   364 VKRLKDVAAGKR--DFEQQMEIIGGIKHENVVELKAYYYSKDEKLMVYDYFSRGSVASLLHGNRG 426

  Fly   839 K------FQTLQLIVMLRGIASGMSYLSDMN---YVHRDLAARNVLVNAQLICKIADFGLSREIE 894
            :      ::|...|.:  |.|.|::.:...|   .||.::.:.|:.:|::....::|.||:..:.
plant   427 ENRIPLDWETRMKIAI--GAAKGIARIHKENNGKLVHGNIKSSNIFLNSESNGCVSDLGLTAVMS 489

  Fly   895 NASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIE 959
            ..:...:.:.|     :.|||....||.:..|||:|:||||.|::: |:.|....:..::|..:.
plant   490 PLAPPISRQAG-----YRAPEVTDTRKSSQLSDVYSFGVVLLELLT-GKSPIHTTAGDEIIHLVR 548

  Fly   960 KGYRLPAPMDCPEA-----------------LYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQ 1007
            ..:.:.......|.                 :.|:.:.|..|....||..:.:|..::|:..:..
plant   549 WVHSVVREEWTAEVFDIELLRYTNIEEEMVEMLQIAMSCVVKAADQRPKMSDLVRLIENVGNRRT 613

  Fly  1008 SLLTTRPSPE 1017
            |:   .|.||
plant   614 SI---EPEPE 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	11/88 (13%)
		FN3	536..623	CDD:238020	17/104 (16%)
		EphA2_TM	644..736	CDD:291255	19/100 (19%)
		PTKc_EphR	736..1002	CDD:270629	63/291 (22%)
		Pkinase_Tyr	741..999	CDD:285015	63/283 (22%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT4G23740	NP_001328543.1	PLN00113	33..>206	CDD:215061	27/173 (16%)
		leucine-rich repeat	95..118	CDD:275380	3/22 (14%)
		leucine-rich repeat	119..142	CDD:275380	1/22 (5%)
		leucine-rich repeat	143..166	CDD:275380	5/22 (23%)
		leucine-rich repeat	167..189	CDD:275380	4/21 (19%)
		PKc_like	343..607	CDD:419665	63/279 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050