DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and AT3G46370

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001319694.1	Gene:	AT3G46370 / 823783	AraportID:	AT3G46370	Length:	793	Species:	Arabidopsis thaliana

Alignment Length:	904	Identity:	189/904 - (20%)
Similarity:	317/904 - (35%)	Gaps:	290/904 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 VTENFAHF---NETP-----------------------TGREITIIEKQNGTCVDNAEPYETPTY 302
            ||.|:.::   ||.|                       |.:||..|.|.|...|
plant    19 VTSNYGNYDGRNEPPRFDLYLGPNFWVTIDLGKHVNGDTWKEIIHIPKSNSLDV----------- 72

  Fly   303 LCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECP-LGTFKSPEVTKCTPCPPNSNASKTGSPFCK 366
                          |..|.|          |..| :.|.:...:.|.:....:.:...|...|..
plant    73 --------------CLIKTG----------TTTPIISTLELRSLPKYSYNAISGSLKSTLRAFLS 113

  Fly   367 CASGFYRHPNDGRHMPCYSPPAAP----------TNL----------------TLLFVDQTSAII 405
            .::...|:|||     .|.....|          |||                |......|||.:
plant   114 ESTEVIRYPND-----FYDRMWVPHFETEWKQISTNLKVNSSNGYLLPQDVLMTAAIPVNTSARL 173

  Fly   406 SWSAPAKNESFSSETNSKIYHSDIVYKIKCN------------ICSPN---------VVYNPSTD 449
            |::   :|..|..:.....:|...|..::.|            :..|:         .||||| .
plant   174 SFT---ENLEFPHDELYLYFHFSEVQVLQANQSREFSILWNGMVIYPDFIPDYLGAATVYNPS-P 234

  Fly   450 TFNETKITLTNLEPVTTYTVQ--IHAINSVSHINEFKRHSNESSLVAVSDI-------------- 498
            :..|....|..||.....|:.  ::||...:.:|..:..:|:..::|::.|
plant   235 SLCEVGKCLLELERTQKSTLPPLLNAIEVFTVMNFPQSETNDDDVIAITKIKDTHRLNRTSWQGD 299

  Fly   499 -----VFS-------NTSLLNIP--LDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADL 549
                 :||       :|::...|  :.||...:|....:.|.    :..:..|:.|.::|.:.
plant   300 PCVPQLFSWAGLSCIDTNVSTPPRIISLNLSSSGLTGNIATG----IQNLTKLQKLDLSNNNL-- 358

  Fly   550 EWDKPVQSDF-----PLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTN 609
               ..|..:|     .|.|.::|           |:.||....|.    ||:..:.|.|:....:
plant   359 ---TGVVPEFLANMKSLLFIDLR-----------KNKLNGSIPKT----LLDRKKKGLQLFVDGD 405

  Fly   610 NGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKS 674
            :..|..:..:....:..:      ...:..:|.|:...|:..|:.|:  ::..|.|      |||
plant   406 DDKGDDNKCLSGSCVPKM------KFPLMIVALAVSAVVVIAVVMIL--IFLFRKK------KKS 456

  Fly   675 TNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDAN 739
            :    |.:..|:....|::|                 ..|.:    ||.:..:..:.|
plant   457 S----LGITSAAISEESIET-----------------KRRRF----TYSEVVEMTKNF------- 489

  Fly   740 YITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNV 804
                :..:|.|.||.|..|.|.      ....||:|.|...||:..: .|..|..::.:..|.|:
plant   490 ----QKTLGEGGFGTVYYGNLN------GSEQVAVKVLSQSSSQGYK-HFKAEVELLLRVHHINL 543

  Fly   805 IYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDG----KFQT-LQLIVMLRGIASGMSYLSDMNY 864
            :.|.|.....|.:.:|.|.|.||.|...|....|    |:.| |::.|   ..|.|:.||   :|
plant   544 VSLVGYCDERNHLALIYECMSNGDLKDHLSGKKGNAVLKWSTRLRIAV---DAALGLEYL---HY 602

  Fly   865 ------VHRDLAARNVLVNAQLICKIADFGLSR--EIENASDAYTTRGGKIPVRWTAPEAIAFRK 921
                  ||||:.:.|:|::.||:.|||||||||  ::...|.|.|...|.:  .:..||.....:
plant   603 GCRPSIVHRDVKSTNILLDDQLMAKIADFGLSRSFKLGEESQASTVVAGTL--GYLDPEYYRTCR 665

  Fly   922 FTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVI-KSIEKGY---------------RLPAP-MD 969
            ....|||:|:|::|.|::          :||:|| .:.||.:               |:..| :|
plant   666 LAEMSDVYSFGILLLEII----------TNQNVIDHAREKAHITEWVGLVLKGGDVTRIVDPNLD 720

  Fly   970 CP-------EALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGN 1021
            ..       .|| :|.:.|......|||..:.:|..|........|:...:...::||:
plant   721 GEYNSRSVWRAL-ELAMSCANPSSEHRPIMSQVVIDLKECLNTENSMKIKKNDTDNDGS 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	27/137 (20%)
		FN3	536..623	CDD:238020	17/91 (19%)
		EphA2_TM	644..736	CDD:291255	16/91 (18%)
		PTKc_EphR	736..1002	CDD:270629	85/302 (28%)
		Pkinase_Tyr	741..999	CDD:285015	84/294 (29%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT3G46370	NP_001319694.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050