DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and MEE39

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_190217.2	Gene:	MEE39 / 823778	AraportID:	AT3G46330	Length:	878	Species:	Arabidopsis thaliana

Alignment Length:	877	Identity:	172/877 - (19%)
Similarity:	293/877 - (33%)	Gaps:	277/877 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 GDGKWT-----ILTGG----------------CRCKAGYEPNYTNKTCTECPLGTFKSPEVTKCT 349
            |..|||     |:..|                |..|.|               .|.......:..
plant   130 GPNKWTTIDLQIVPDGTVKEIIHIPRSNSLQICLVKTG---------------ATIPMISALELR 179

  Fly   350 PCPPNSNASKTGS------PFCKCASGFYRHPND-------------------------GRHMPC 383
            |...::..:|:||      .:...|:...|:|.|                         ..|
plant   180 PLANDTYIAKSGSLKYYFRMYLSNATVLLRYPKDVYDRSWVPYIQPEWNQISTTSNVSNKNH--- 241

  Fly   384 YSPP-------AAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIY---HSDIVYKIKCNIC 438
            |.||       |.||||      ..:..:.|..        ...:.:||   |...:..:|.|..
plant   242 YDPPQVALKMAATPTNL------DAALTMVWRL--------ENPDDQIYLYMHFSEIQVLKANDT 292

  Fly   439 SP-NVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAIN-SVSHINEFKRHSNESSLVAVSDIVFS 501
            .. :::.|  .:|.|...:|...||.:|..|......| .:..:...|  :.:|:|..:.: .|.
plant   293 REFDIILN--GETINTRGVTPKYLEIMTWLTTNPRQCNGGICRMQLTK--TQKSTLPPLLN-AFE 352

  Fly   502 NTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSD--FPLEFY 564
            ..|:|.:|    :.:|.:.|:|         .:.|:|   .|...:.:.|    |.|  .|.:|.
plant   353 VYSVLQLP----QSQTNEIEVV---------AIKNIR---TTYGLSRISW----QGDPCVPKQFL 397

  Fly   565 EVRWFPKVELDAINKSA-------------LNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYS 616
               |      |.:|.:.             |::......||...:|..:...:....|:..|
plant   398 ---W------DGLNCNITDISAPPRIISLNLSSSGLSGTIVSNFQNLAHLESLDLSNNSLSG--- 450

  Fly   617 NMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLP 681
              |..:.|.::.|:...::....::|||...              :|.:.::.          |.
plant   451 --IVPEFLATMKSLLVINLSGNKLSGAIPQA--------------LRDREREG----------LK 489

  Fly   682 LDYASNEVNSMDTTPI---VKKLHLNVTTPLFG-----------------NSRSYVDP------- 719
            |:...|:...:.:|.|   .||:.:.|..|:..                 :||:..:|
plant   490 LNVLGNKELCLSSTCIDKPKKKVAVKVVAPVASIAAIVVVILLFVFKKKMSSRNKPEPWIKTKKK 554

  Fly   720 -HTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSE 783
             .||.:..:..:...|.           :|.|.||.|..|.|.      ....||:|.|...|::
plant   555 RFTYSEVMEMTKNLQRP-----------LGEGGFGVVYHGDLN------GSEQVAVKLLSQTSAQ 602

  Fly   784 KARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKF-------- 840
            ..: :|..|..::.:..|.|::.|.|.....:...:|.|||.||.|...|   .||.
plant   603 GYK-EFKAEVELLLRVHHINLVNLVGYCDEQDHFALIYEYMSNGDLHQHL---SGKHGGSVLNWG 663

  Fly   841 QTLQLIVMLRGIASGMSYL---SDMNYVHRDLAARNVLVNAQLICKIADFGLSREIE---NASDA 899
            ..||:.:   ..|.|:.||   .....||||:.:.|:|::.:...|||||||||..:   :.|..
plant   664 TRLQIAI---EAALGLEYLHTGCKPAMVHRDVKSTNILLDEEFKAKIADFGLSRSFQVGGDQSQV 725

  Fly   900 YTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKS------- 957
            .|...|.:  .:..||.....:.:..|||:|:|::|.|::          :||.||..
plant   726 STVVAGTL--GYLDPEYYLTSELSEKSDVYSFGILLLEII----------TNQRVIDQTRENPNI 778

  Fly   958 -------IEKG-------YRLPAPMDCPEA--LYQLMLDCWQKQRTHRPTFASIVSTLDNLARQP 1006
                   |:||       .:|....|....  ..::.:.|.......||..:.::..|.......
plant   779 AEWVTFVIKKGDTSQIVDPKLHGNYDTHSVWRALEVAMSCANPSSVKRPNMSQVIINLKECLASE 843

  Fly  1007 QSLLTTRPSPESDGNHILDGQRGQNIFISTDL 1038
            .:.: :|.:...|..|..| |....:...||:
plant   844 NTRI-SRNNQNMDSGHSSD-QLNVTVTFDTDV 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	21/100 (21%)
		FN3	536..623	CDD:238020	18/101 (18%)
		EphA2_TM	644..736	CDD:291255	17/119 (14%)
		PTKc_EphR	736..1002	CDD:270629	74/302 (25%)
		Pkinase_Tyr	741..999	CDD:285015	73/294 (25%)
		SAM_1	1033..1092	CDD:278937	2/6 (33%)
		SAM	1039..1092	CDD:197735	172/877 (20%)
MEE39	NP_190217.2	Malectin_like	34..356	CDD:372329	46/262 (18%)
		PLN00113	<434..>480	CDD:215061	9/64 (14%)
		leucine-rich repeat	438..461	CDD:275380	4/27 (15%)
		leucine-rich repeat	462..492	CDD:275380	6/53 (11%)
		STKc_IRAK	572..833	CDD:270968	73/285 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050