DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and NIK2

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001189971.1	Gene:	NIK2 / 822143	AraportID:	AT3G25560	Length:	647	Species:	Arabidopsis thaliana

Alignment Length:	636	Identity:	136/636 - (21%)
Similarity:	251/636 - (39%)	Gaps:	132/636 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   415 SFSSETNSKIYHSDIV--YKIKCNICSPN-VVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINS 476
            |.|:|...|..:.::|  ..||.::..|: |:.|     :::|.:...:...:|.....:..:.:
plant    29 SSSAELTDKGVNFEVVALIGIKSSLTDPHGVLMN-----WDDTAVDPCSWNMITCSDGFVIRLEA 88

  Fly   477 VSHINEFKRHSNESSLVAVSDIVFSNTSLL-NIPLDLNEVK------------TGQAEIVFTTES 528
            .|........|:..:|..:..::..|..:. |||.::.::.            |||  |.||
plant    89 PSQNLSGTLSSSIGNLTNLQTVLLQNNYITGNIPHEIGKLMKLKTLDLSTNNFTGQ--IPFT--- 148

  Fly   529 VLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVG 593
              ||...||:.|.:.|..        :....|.....:.....::|...|.|. ....:.|....
plant   149 --LSYSKNLQYLRVNNNS--------LTGTIPSSLANMTQLTFLDLSYNNLSG-PVPRSLAKTFN 202

  Fly   594 LLENTEY---GFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIA---GAIVTGVLFLV 652
            ::.|::.   |.:..|   ||.......|...:.|:..|  |...:.|.||   |..:|.|..|:
plant   203 VMGNSQICPTGTEKDC---NGTQPKPMSITLNSSQNKSS--DGGTKNRKIAVVFGVSLTCVCLLI 262

  Fly   653 I---FIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSR 714
            |   |::    :.|.:|...:           |.:..||.|..:.              ..||.|
plant   263 IGFGFLL----WWRRRHNKQV-----------LFFDINEQNKEEM--------------CLGNLR 298

  Fly   715 SYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKP 779
            .:    .:::...|...|:.         :.::|.|.||:|.:|.|.      ....:|:|.||.
plant   299 RF----NFKELQSATSNFSS---------KNLVGKGGFGNVYKGCLH------DGSIIAVKRLKD 344

  Fly   780 GSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVND----GKF 840
            .::......|.||..::....|.|::.|.|..|.|:..:::..||.|||:.:.|:...    |..
plant   345 INNGGGEVQFQTELEMISLAVHRNLLRLYGFCTTSSERLLVYPYMSNGSVASRLKAKPVLDWGTR 409

  Fly   841 QTLQLIVMLRGIASGMSYL---SDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTT 902
            :.:.|     |...|:.||   .|...:|||:.|.|:|::......:.||||::.:::.....||
plant   410 KRIAL-----GAGRGLLYLHEQCDPKIIHRDVKAANILLDDYFEAVVGDFGLAKLLDHEESHVTT 469

  Fly   903 --RGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEV------MSYGERPYWNWSNQDVIKSIE 959
              ||   .|...|||.::..:.:..:||:.:|::|.|:      :.:|:......:..|.:|.::
plant   470 AVRG---TVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGLRALEFGKAANQRGAILDWVKKLQ 531

  Fly   960 KGYRLPAPMDCP----------EALYQLMLDCWQKQRTHRPTFASIVSTLD 1000
            :..:|...:|..          |.:.|:.|.|.|....|||..:.:|..|:
plant   532 QEKKLEQIVDKDLKSNYDRIEVEEMVQVALLCTQYLPIHRPKMSEVVRMLE 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	12/63 (19%)
		FN3	536..623	CDD:238020	15/89 (17%)
		EphA2_TM	644..736	CDD:291255	16/94 (17%)
		PTKc_EphR	736..1002	CDD:270629	71/290 (24%)
		Pkinase_Tyr	741..999	CDD:285015	70/282 (25%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
NIK2	NP_001189971.1	LRRNT_2	40..79	CDD:285463	8/43 (19%)
		leucine-rich repeat	107..130	CDD:275380	4/22 (18%)
		LRR_8	130..189	CDD:290566	14/73 (19%)
		leucine-rich repeat	131..154	CDD:275380	8/29 (28%)
		LRR_4	153..190	CDD:289563	7/44 (16%)
		leucine-rich repeat	155..178	CDD:275380	4/30 (13%)
		leucine-rich repeat	179..198	CDD:275380	3/19 (16%)
		PKc_like	318..584	CDD:304357	71/279 (25%)
		TyrKc	319..581	CDD:197581	70/275 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050