DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT3G21340

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_188771.2	Gene:	AT3G21340 / 821688	AraportID:	AT3G21340	Length:	899	Species:	Arabidopsis thaliana

Alignment Length:	757	Identity:	170/757 - (22%)
Similarity:	280/757 - (36%)	Gaps:	242/757 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 PAKNESFSSETNSKIYHSDIVYK-IKCNICSPNVV----YNPSTDTFNETKITLTNLE------- 462
            |.||.::::::.|..|.....:. ...||..|:.|    :.|..|....|::| |||.
plant   182 PLKNNTYNTQSGSLKYFFRYYFSGSGQNIRYPDDVNDRKWYPFFDAKEWTELT-TNLNINSSNGY 245

  Fly   463 ------------PVTTY------------TVQIHAINSVSHI--------NEFK----------R 485
                        |::|:            |.|.:.....:.|        .|||          |
plant   246 APPEVVMASASTPISTFGTWNFSWLLPSSTTQFYVYMHFAEIQTLRSLDTREFKVTLNGKLAYER 310

  Fly   486 HSNESSLVAVSDIVFS-------NTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAI- 542
            :|.::  :|...|.:|       .|.||              |:..|.:|.|...:..|.:..:
plant   311 YSPKT--LATETIFYSTPQQCEDGTCLL--------------ELTKTPKSTLPPLMNALEVFTVI 359

  Fly   543 ------TNKDADLEWDKPVQSDFPLEFYEVRW-----FPKVEL-DAINKSALNTKE--------- 586
                  ||.| |:...|.:||.:.|.  ::.|     .||..| :.:|.:.|:...
plant   360 DFPQMETNPD-DVAAIKSIQSTYGLS--KISWQGDPCVPKQFLWEGLNCNNLDNSTPPIVTSLNL 421

  Fly   587 TKAHIVGL----LENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSV------GSVYDDSVQ----- 636
            :.:|:.|:    ::|..:..::....||..|....  :...::|:      |:.::.|:.
plant   422 SSSHLTGIIAQGIQNLTHLQELDLSNNNLTGGIPE--FLADIKSLLVINLSGNNFNGSIPQILLQ 484

  Fly   637 ---IRFI--------------------AGA--------IVTGVLFLVIFIIATVYFMRSKHQDDL 670
               ::.|                    .||        ||..|.|:|:...|..:|...|
plant   485 KKGLKLILEGNANLICPDGLCVNKAGNGGAKKMNVVIPIVASVAFVVVLGSALAFFFIFK----- 544

  Fly   671 DKKSTNHLPL-PLDYAS-NEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFA 733
            .||::|...| |..|.. :||.::.::          .:.:...:|.:    ||.:.......|
plant   545 KKKTSNSQDLGPSSYTQVSEVRTIRSS----------ESAIMTKNRRF----TYSEVVTMTNNF- 594

  Fly   734 REIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQ 798
                      |.::|.|.||.|..|.:.   |..|   ||:|.|...||:..: :|..|..::.:
plant   595 ----------ERVLGKGGFGMVYHGTVN---NTEQ---VAVKMLSHSSSQGYK-EFKAEVELLLR 642

  Fly   799 FDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDG----KFQT-LQLIVMLRGIASGMSY 858
            ..|.|::.|.|.......:.:|.|||.||.|...:....|    .::| |:::|   ..|.|:.|
plant   643 VHHKNLVGLVGYCDEGENLALIYEYMANGDLREHMSGKRGGSILNWETRLKIVV---ESAQGLEY 704

  Fly   859 LSD---MNYVHRDLAARNVLVNAQLICKIADFGLSRE--IENASDAYTTRGGKIPVRWTAPEAIA 918
            |.:   ...||||:...|:|:|..|..|:|||||||.  ||..:...|...|  ...:..||...
plant   705 LHNGCKPPMVHRDVKTTNILLNEHLHAKLADFGLSRSFPIEGETHVSTVVAG--TPGYLDPEYYR 767

  Fly   919 FRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVI-KSIEK-------GYRLPAP-----MDC 970
            .......|||:|:|:||.|::          :||.|| :|.||       |..|...     ||
plant   768 TNWLNEKSDVYSFGIVLLEII----------TNQLVINQSREKPHIAEWVGLMLTKGDIQNIMD- 821

  Fly   971 PEALY------------QLMLDCWQKQRTHRPTFASIVSTLD 1000
            |: ||            :|.:.|.......|||.:.:|..|:
plant   822 PK-LYGDYDSGSVWRAVELAMSCLNPSSARRPTMSQVVIELN 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	20/101 (20%)
		FN3	536..623	CDD:238020	21/112 (19%)
		EphA2_TM	644..736	CDD:291255	20/93 (22%)
		PTKc_EphR	736..1002	CDD:270629	87/300 (29%)
		Pkinase_Tyr	741..999	CDD:285015	86/292 (29%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT3G21340	NP_188771.2	Malectin_like	36..357	CDD:289580	37/191 (19%)
		LRR_8	416..474	CDD:290566	8/59 (14%)
		leucine-rich repeat	416..439	CDD:275380	3/22 (14%)
		leucine-rich repeat	440..463	CDD:275380	3/24 (13%)
		leucine-rich repeat	464..480	CDD:275380	2/15 (13%)
		TyrKc	594..861	CDD:197581	87/301 (29%)
		STKc_IRAK	598..863	CDD:270968	86/289 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050