DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and RLK902

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_566589.1	Gene:	RLK902 / 821053	AraportID:	AT3G17840	Length:	647	Species:	Arabidopsis thaliana

Alignment Length:	722	Identity:	143/722 - (19%)
Similarity:	263/722 - (36%)	Gaps:	203/722 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 TNLTLLFVDQTSAIISWSAPAKNE---------SFSSETNSKIYHSDIVYKIKCN----ICSPNV 442
            :||::.|   :..::|...|:..:         ||.|....:....|:.....||    :|
plant    10 SNLSIFF---SILLLSLPLPSIGDLAADKSALLSFRSAVGGRTLLWDVKQTSPCNWTGVLC---- 67

  Fly   443 VYNPSTDTFNETKITLT--------------NLEPVTTYTVQIHA--------INSVSHINEFKR 485
                  |....|.:.|.              ||..:.|.:::::.        :.|.|.:.....
plant    68 ------DGGRVTALRLPGETLSGHIPEGIFGNLTQLRTLSLRLNGLTGSLPLDLGSCSDLRRLYL 126

  Fly   486 HSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNK----- 545
            ..|..| ..:.:::||.::|:.:.|..||. :|:....|       ..:..|:.|.:.|.
plant   127 QGNRFS-GEIPEVLFSLSNLVRLNLAENEF-SGEISSGF-------KNLTRLKTLYLENNKLSGS 182

  Fly   546 --DADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSAL-----------NTKETKAHIVGLLEN 597
              |.||..|:...|:..|.....:...|.:.|:...::|           .|..::...||.:..
plant   183 LLDLDLSLDQFNVSNNLLNGSIPKSLQKFDSDSFVGTSLCGKPLVVCSNEGTVPSQPISVGNIPG 247

  Fly   598 TEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFM 662
            |..|.:.:.|.....|.                        .|||.::..|:.|.:.::..:...
plant   248 TVEGSEEKKKRKKLSGG------------------------AIAGIVIGCVVGLSLIVMILMVLF 288

  Fly   663 RSKHQD-----DLDKKSTNHLPLPLDYASNE-------VNSMDTTPIVKKLHLNVT----TPLFG 711
            |.|..:     ||.....:.:.:|.:.|:.|       ||....: .||.:.:|.:    ...||
plant   289 RKKGNERTRAIDLATIKHHEVEIPGEKAAVEAPENRSYVNEYSPS-AVKAVEVNSSGMKKLVFFG 352

  Fly   712 NSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDID----V 772
            |:....|   .||..:|..|              ::|.|.||...:..|          |    |
plant   353 NATKVFD---LEDLLRASAE--------------VLGKGTFGTAYKAVL----------DAVTLV 390

  Fly   773 AIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVND 837
            |:|.||  ....|..:|..:..::|..||.|::.|:......:..:::.::|..|||...|..|.
plant   391 AVKRLK--DVTMADREFKEKIEVVGAMDHENLVPLRAYYYSGDEKLLVYDFMPMGSLSALLHGNK 453

  Fly   838 G------KFQTLQLIVMLRGIASGMSYLSDMNYV--HRDLAARNVLVNAQLICKIADFGLSREIE 894
            |      .::....|.:  |.|.|:.||...:.:  |.::.:.|:|:......:::||||::.:.
plant   454 GAGRPPLNWEVRSGIAL--GAARGLDYLHSQDPLSSHGNVKSSNILLTNSHDARVSDFGLAQLVS 516

  Fly   895 NASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERP-------------Y 946
            .:|.......|     :.|||....|:.:..:||:|:||||.|::: |:.|             .
plant   517 ASSTTPNRATG-----YRAPEVTDPRRVSQKADVYSFGVVLLELLT-GKAPSNSVMNEEGMDLAR 575

  Fly   947 W-------NWSNQ---------DVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASI 995
            |       .|.|:         :.:.|:|:        :..|.| ||.:||.::....||....:
plant   576 WVHSVAREEWRNEVFDSELMSIETVVSVEE--------EMAEML-QLGIDCTEQHPDKRPVMVEV 631

  Fly   996 VSTLDNL 1002
            |..:..|
plant   632 VRRIQEL 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	18/119 (15%)
		FN3	536..623	CDD:238020	19/104 (18%)
		EphA2_TM	644..736	CDD:291255	22/107 (21%)
		PTKc_EphR	736..1002	CDD:270629	68/306 (22%)
		Pkinase_Tyr	741..999	CDD:285015	68/298 (23%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
RLK902	NP_566589.1	PLN00113	38..>208	CDD:215061	34/188 (18%)
		leucine-rich repeat	97..120	CDD:275380	2/22 (9%)
		leucine-rich repeat	121..144	CDD:275380	4/23 (17%)
		leucine-rich repeat	145..168	CDD:275380	6/30 (20%)
		STKc_IRAK	371..638	CDD:270968	68/295 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050