DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and AT3G14840

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_188102.5	Gene:	AT3G14840 / 820713	AraportID:	AT3G14840	Length:	1020	Species:	Arabidopsis thaliana

Alignment Length:	759	Identity:	169/759 - (22%)
Similarity:	279/759 - (36%)	Gaps:	218/759 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 NYTNKTCTEC---PLGTFKSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPP 387
            |::.....||   .:.||.|     .:|...|::::.:......|...||     |.|:.| ...
plant   359 NFSKDKTEECQQKSVNTFSS-----TSPLVANNSSNVSCLSKYTCPKTFY-----GLHINC-GGN 412

  Fly   388 AAPTNLTLLFVDQTSAIISWSAP----AKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPST 448
            ...:|.|....|      :|..|    :||...||.|.              |....:...|..:
plant   413 EITSNETKYDAD------TWDTPGYYDSKNGWVSSNTG--------------NFLDDDRTNNGKS 457

  Fly   449 DTFNETKITLTN------------LEPVT-----------TYTVQIHAINSVSHINEFKRHSNES 490
            ...|.:::.:||            |..::           .|||.:|....:  .||...:||..
plant   458 KWSNSSELKITNSSIDFRLYTQARLSAISLTYQALCLGKGNYTVNLHFAEIM--FNEKNMYSNLG 520

  Fly   491 SLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNK-DADLEWDKP 554
            .  ...||.....         .|||  ...||...:.|..:.|....::....| :..|:|...
plant   521 R--RYFDIYVQGK---------REVK--DFNIVDEAKGVGKAVVKKFPVMVTNGKLEIRLQWAGK 572

  Fly   555 VQSDFPLEFYEVR--WFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSN 617
            .....|     ||  :.|.:...:::...:..||.                   .|..|.||
plant   573 GTQAIP-----VRGVYGPLISAVSVDPDFIPPKEP-------------------GTGTGGGS--- 610

  Fly   618 MIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYF---MRSKHQDDLDKKSTNHLP 679
                    |||:|          .|:::...:|||:.|...:::   :|.|.|.:.|.|:
plant   611 --------SVGTV----------VGSVIASTVFLVLLIGGILWWRGCLRPKSQMEKDFKN----- 652

  Fly   680 LPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIE 744
              ||:   :::|.....|      .|.|..|             ||            ||.
plant   653 --LDF---QISSFSLRQI------KVATDNF-------------DP------------ANK---- 677

  Fly   745 AIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQG 809
              ||.|.||.|.:|.:      .....:|:|.|...|.:..| :||.|.:::....||:::.|.|
plant   678 --IGEGGFGPVHKGIM------TDGTVIAVKQLSAKSKQGNR-EFLNEIAMISALQHPHLVKLYG 733

  Fly   810 VVTRSNPVMIITEYMENGSL--------DTFLRVNDGKFQTLQLIVMLRGIASGMSYL---SDMN 863
            .....:.::::.||:||.||        :|.:.:|   :...|.|.:  |||.|::||   |.:.
plant   734 CCVEGDQLLLVYEYLENNSLARALFGPQETQIPLN---WPMRQKICV--GIARGLAYLHEESRLK 793

  Fly   864 YVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTR-GGKIPVRWTAPEAIAFRKFTSASD 927
            .||||:.|.|||::.:|..||:||||::..|..:...:|| .|  ...:.|||.......|..:|
plant   794 IVHRDIKATNVLLDKELNPKISDFGLAKLDEEENTHISTRVAG--TYGYMAPEYAMRGHLTDKAD 856

  Fly   928 VWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGY--------------RLPAPMDCPEALYQLM 978
            |:|:|||..|:: :|:....:.|..|....::..:              ||....:..|||..:.
plant   857 VYSFGVVALEIV-HGKSNTSSRSKADTFYLLDWVHVLREQNTLLEVVDPRLGTDYNKQEALMMIQ 920

  Fly   979 LD--CWQKQRTHRPTFASIVSTLDNLAR-QPQSLLTTRPSPESD 1019
            :.  |.......||:.:::||.|:..:. ..:.||....:.|.|
plant   921 IGMLCTSPAPGDRPSMSTVVSMLEGHSTVNVEKLLEASVNNEKD 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	20/115 (17%)
		FN3	536..623	CDD:238020	13/89 (15%)
		EphA2_TM	644..736	CDD:291255	18/94 (19%)
		PTKc_EphR	736..1002	CDD:270629	82/293 (28%)
		Pkinase_Tyr	741..999	CDD:285015	79/285 (28%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT3G14840	NP_188102.5	PLN00113	12..944	CDD:215061	164/737 (22%)
		LRR_RI	57..314	CDD:238064
		leucine-rich repeat	113..135	CDD:275380
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..183	CDD:275380
		leucine-rich repeat	184..207	CDD:275380
		leucine-rich repeat	208..231	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		leucine-rich repeat	256..279	CDD:275380
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..325	CDD:275380
		leucine-rich repeat	328..348	CDD:275380
		Malectin	403..590	CDD:288557	44/232 (19%)
		STKc_IRAK	678..945	CDD:270968	80/281 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050