DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT2G28960

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_180462.2	Gene:	AT2G28960 / 817445	AraportID:	AT2G28960	Length:	880	Species:	Arabidopsis thaliana

Alignment Length:	916	Identity:	198/916 - (21%)
Similarity:	314/916 - (34%)	Gaps:	309/916 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 ATREPPPWQTDSY-------RLIARIAAGEG-----------------RFNQ-NSDVDINTEVKS 230
            :|.|..|.:.|||       .||.|.|....                 |:|: .:||:....|:|
plant   171 STLELRPLRNDSYLTQFGPLDLIYRRAYSSNSTGFIRYPDDIFDRKWDRYNEFETDVNTTLNVRS 235

  Fly   231 I-------AVNKKGV-----------YFAFRDQGACISVLAVKVYYITCPAVTENFAHF-----N 272
            .       ||::.|:           |.:..|...     .|.||:        :||..     |
plant   236 SSPFQVPEAVSRMGITPENASLPLRFYVSLDDDSD-----KVNVYF--------HFAEIQALRGN 287

  Fly   273 ETPTGREITI-IEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECP 336
            ||   ||..| :|:      |..:...:||.| :.|.|:.:  ...:|.:|.           |.
plant   288 ET---REFDIELEE------DIIQSAYSPTML-QSDTKYNL--SPHKCSSGL-----------CY 329

  Fly   337 LGTFKSPEVTKCTPCPPNSNASK----TGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLF 397
            |...::|..|    .||..:|.:    ...|:.:      .:|||         .||..::...:
plant   330 LKLVRTPRST----LPPLISAIEAFKVVDFPYAE------TNPND---------VAAMKDIEAFY 375

  Fly   398 VDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLE 462
               ...:|||..                          :.|.|.::      .:.:.|.:.||..
plant   376 ---GLKMISWQG--------------------------DPCVPELL------KWEDLKCSYTNKS 405

  Fly   463 -PVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSN-TSLLNIPLDLNEVKTGQAEIVFT 525
             |....::.:                :...|..|....|.| |.|..:.|..|....|..|.:.:
plant   406 TPPRIISLDL----------------SSRGLKGVIAPAFQNLTELRKLDLSNNSFTGGVPEFLAS 454

  Fly   526 TESVLLSTVFNLRILAITNKDADLEWDKPVQSDF--PLEFYEVRWFPKVELDAINKSALNTKETK 588
            .:|           |:|.|    |.|     :|.  ||        ||:.||. .|:.|     |
plant   455 MKS-----------LSIIN----LNW-----NDLTGPL--------PKLLLDR-EKNGL-----K 485

  Fly   589 AHIVGLLENTEYGFQVRCKTNNGFGSYSNMIY-AQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLV 652
            ..|.|   |.:......||.||      |..| ...:.||.||            .|:..||.|:
plant   486 LTIQG---NPKLCNDASCKNNN------NQTYIVPVVASVASV------------LIIIAVLILI 529

  Fly   653 IFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTP-LFGNSRSY 716
            :     |:..|...|                        :|:.|.|:  |.....| :|..::.:
plant   530 L-----VFKKRRPTQ------------------------VDSLPTVQ--HGLPNRPSIFTQTKRF 563

  Fly   717 VDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGS 781
                ||.           |::|.....|.::|.|.||.|..|.|    |..|.|  |:|.|.. |
plant   564 ----TYS-----------EVEALTDNFERVLGEGGFGVVYHGIL----NGTQPI--AVKLLSQ-S 606

  Fly   782 SEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDG----KFQT 842
            |.:...:|..|..::.:..|.|::.|.|.....:.:.::.||..||.|...|....|    |:.:
plant   607 SVQGYKEFKAEVELLLRVHHVNLVSLVGYCDEESNLALLYEYAPNGDLKQHLSGERGGSPLKWSS 671

  Fly   843 -LQLIVMLRGIASGMSYL---SDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTR 903
             |:::|   ..|.|:.||   .....||||:...|:|::.....|:|||||||......:.:.:.
plant   672 RLKIVV---ETAQGLEYLHTGCKPPMVHRDVKTTNILLDEHFQAKLADFGLSRSFPVGGETHVST 733

  Fly   904 GGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLP--- 965
            .......:..||.....:....|||:|:|:||.|:::  .||....:.:....:...||.|.
plant   734 AVAGTPGYLDPEYYRTNRLNEKSDVYSFGIVLLEIIT--SRPVIQQTREKPHIAAWVGYMLTKGD 796

  Fly   966 -------------APMDCPEALYQLMLDCWQKQRTHRPTFASIVS------TLDNLARQPQSLLT 1011
                         .|....:|| ::.:.|.......|||.:.:.:      ||:|..|..:..:.
plant   797 IENVVDPRLNRDYEPTSVWKAL-EIAMSCVNPSSEKRPTMSQVTNELKQCLTLENSKRGVREDMG 860

  Fly  1012 TRPSPE 1017
            :|.|.|
plant   861 SRSSVE 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	24/111 (22%)
		FN3	387..476	CDD:238020	11/89 (12%)
		FN3	536..623	CDD:238020	24/89 (27%)
		EphA2_TM	644..736	CDD:291255	15/92 (16%)
		PTKc_EphR	736..1002	CDD:270629	75/295 (25%)
		Pkinase_Tyr	741..999	CDD:285015	72/287 (25%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT2G28960	NP_180462.2	Malectin_like	35..351	CDD:289580	48/219 (22%)
		leucine-rich repeat	410..433	CDD:275380	4/38 (11%)
		leucine-rich repeat	434..457	CDD:275380	5/22 (23%)
		leucine-rich repeat	458..476	CDD:275380	10/34 (29%)
		TyrKc	575..842	CDD:197581	72/279 (26%)
		STKc_IRAK	579..844	CDD:270968	71/277 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960