DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT2G23950

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_179973.2	Gene:	AT2G23950 / 816928	AraportID:	AT2G23950	Length:	634	Species:	Arabidopsis thaliana

Alignment Length:	593	Identity:	133/593 - (22%)
Similarity:	222/593 - (37%)	Gaps:	162/593 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   526 TESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVE-LDAINKSALNTKETKA 589
            |.|..:..:.|||.:::.|.:        :....|.|...:   ||:: ||      |:......
plant    89 TLSGSIGNLTNLRQVSLQNNN--------ISGKIPPEICSL---PKLQTLD------LSNNRFSG 136

  Fly   590 HI---VGLLENTEYGFQVRCKTNNGFG-----------------SYSNM------IYAQTLQSVG 628
            .|   |..|.|.:|   :|...|:..|                 ||:|:      ..|:|....|
plant   137 EIPGSVNQLSNLQY---LRLNNNSLSGPFPASLSQIPHLSFLDLSYNNLRGPVPKFPARTFNVAG 198

  Fly   629 -----------------SVYDDSVQIRFIAG------AIVTGVL--FLVIFIIATVYFMRSKHQD 668
                             |....||.:|..:|      |:..||.  |.|..|::..:....|.|.
plant   199 NPLICKNSLPEICSGSISASPLSVSLRSSSGRRTNILAVALGVSLGFAVSVILSLGFIWYRKKQR 263

  Fly   669 DL------DKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQ 727
            .|      ||:....|.|                              ||.||:    |:.:.:.
plant   264 RLTMLRISDKQEEGLLGL------------------------------GNLRSF----TFRELHV 294

  Fly   728 AIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTE 792
            |...|:.         ::|:|.|.||:|.||:      |.....||:|.||..:.......|.||
plant   295 ATDGFSS---------KSILGAGGFGNVYRGK------FGDGTVVAVKRLKDVNGTSGNSQFRTE 344

  Fly   793 ASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDG-KFQTLQLIVMLRGIASGM 856
            ..::....|.|::.|.|....|:..:::..||.|||:.:.|:.... .:.|.:.|.:  |.|.|:
plant   345 LEMISLAVHRNLLRLIGYCASSSERLLVYPYMSNGSVASRLKAKPALDWNTRKKIAI--GAARGL 407

  Fly   857 SYL---SDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIA 918
            .||   .|...:|||:.|.|:|::......:.||||:: :.|..|::.|...:..|...|||.::
plant   408 FYLHEQCDPKIIHRDVKAANILLDEYFEAVVGDFGLAK-LLNHEDSHVTTAVRGTVGHIAPEYLS 471

  Fly   919 FRKFTSASDVWSYGVVLWEV------MSYGERPYWNWSNQDVIKSIEKGYRLPAPMD-------- 969
            ..:.:..:||:.:|::|.|:      :.:|:......:..:.::.:.|..::...:|
plant   472 TGQSSEKTDVFGFGILLLELITGMRALEFGKSVSQKGAMLEWVRKLHKEMKVEELVDRELGTTYD 536

  Fly   970 ---CPEALYQLMLDCWQKQRTHRPTFASIVSTL--DNLARQPQSLLTTRPSPESDGNHILDGQRG 1029
               ..|.| |:.|.|.|....|||..:.:|..|  |.||.        |.:...|.:|.......
plant   537 RIEVGEML-QVALLCTQFLPAHRPKMSEVVQMLEGDGLAE--------RWAASHDHSHFYHANMS 592

  Fly  1030 QNIFISTD 1037
            .....|||
plant   593 YRTITSTD 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020
		FN3	536..623	CDD:238020	23/113 (20%)
		EphA2_TM	644..736	CDD:291255	19/99 (19%)
		PTKc_EphR	736..1002	CDD:270629	73/288 (25%)
		Pkinase_Tyr	741..999	CDD:285015	71/278 (26%)
		SAM_1	1033..1092	CDD:278937	3/5 (60%)
		SAM	1039..1092	CDD:197735
AT2G23950	NP_179973.2	PLN00113	13..>188	CDD:215061	24/118 (20%)
		leucine-rich repeat	100..123	CDD:275380	5/33 (15%)
		leucine-rich repeat	124..147	CDD:275380	6/28 (21%)
		leucine-rich repeat	148..171	CDD:275380	4/25 (16%)
		leucine-rich repeat	172..195	CDD:275380	5/22 (23%)
		PKc_like	305..571	CDD:419665	71/275 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050