DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and AT2G19210

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_179511.1	Gene:	AT2G19210 / 816438	AraportID:	AT2G19210	Length:	881	Species:	Arabidopsis thaliana

Alignment Length:	1017	Identity:	205/1017 - (20%)
Similarity:	348/1017 - (34%)	Gaps:	296/1017 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 EESFTDFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFT-----IRDCSLFPGN 173
            :.|:.|....|.:    |.|.|           |::.|:.:.:..|.|.:     .::...||..
plant    41 DSSYNDETTDIKY----VSDAA-----------FVESGTIHSIDPEFQTSSLEKQFQNVRSFPEG 90

  Fly   174 ALSCKETFSLLFYEFDAATREPPPWQTDSYRLIARIAAGE-GRFNQNSDVDINTEVKSIAVNKKG 237
            ..:|.:.             :||..:...|.:..|...|. ....:..|.|:
plant    91 NRNCYDV-------------KPPQGKGFKYLIRTRFMYGNYDNLGKAPDFDL------------- 129

  Fly   238 VYFAFR-------DQGACISVLAVKVYYITCPAVTENFAHFNETPTGR----EITIIEKQNGTCV 291
             |..|.       |....|              ||:...|     |.|    .:.:::|..||..
plant   130 -YLGFNIWDSVTIDNATTI--------------VTKEIIH-----TLRSDHVHVCLVDKNRGTPF 174

  Fly   292 DNA--------EPYETP---TYLCKGDGKWTILTGGC-RCKAGYEPNYTNKTCTECPLGTFKSPE 344
            .:|        ..||||   ..|.|   :|.:  ||. .....|:.:..::..  .||   :.|:
plant   175 LSALEIRLLKSNTYETPYDSLILFK---RWDL--GGLGALPVRYKDDVFDRIW--IPL---RFPK 229

  Fly   345 VTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAII-SWS 408
            .|       ..|||.|          ...:.|:|     :.|.....|......|.:..|| ||.
plant   230 YT-------IFNASLT----------IDSNNNEG-----FQPARFVMNTATSPEDLSQDIIFSWE 272

  Fly   409 APAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDT------FNETKITLTNLEPVTTY 467
            .                 .|..:|....:....||..||.:|      .||.:|.:::..|...|
plant   273 P-----------------KDPTWKYFVYMHFAEVVELPSNETREFKVLLNEKEINMSSFSPRYLY 320

  Fly   468 TVQIHAINSVSHIN-EFK-RHSNESSLVAVSDIV--FSNTSLLNIPLDLNEV--------KTGQ- 519
            |..:...|.||... ||: :.:..|:|..:.:.:  :.....|..|.|..:|        |.|.
plant   321 TDTLFVQNPVSGPKLEFRLQQTPRSTLPPIINAIETYRVNEFLQSPTDQQDVDAIMRIKSKYGVK 385

  Fly   520 --------AEIVFTTESVLLSTVFN--LRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVEL 574
                    |.:.:..:.:..|.|.|  .||:::....:.|..                     |:
plant   386 KSWLGDPCAPVKYPWKDINCSYVDNESPRIISVNLSSSGLTG---------------------EI 429

  Fly   575 DAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRF 639
            ||...:.     |..||:.|..|:..|     |..:..|:..|:   ..|...|:....::.::.
plant   430 DAAFSNL-----TLLHILDLSNNSLTG-----KIPDFLGNLHNL---TELNLEGNKLSGAIPVKL 481

  Fly   640 IAGAIVTGVLFLV-----IFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVK 699
            :..:....:|..:     :.:.|:...     .|:..||:...:||             ...:|.
plant   482 LERSNKKLILLRIDGNPDLCVSASCQI-----SDEKTKKNVYIIPL-------------VASVVG 528

  Fly   700 KLHLNVTTPLF------------GNSRSYVDPHTYEDPNQAIREFAREIDANYIT--IEAIIGGG 750
            .|.|.:...||            |..|:        .|....:.:.:..:...:|  .|.::|.|
plant   529 VLGLVLAIALFLLYKKRHRRGGSGGVRA--------GPLDTTKRYYKYSEVVKVTNNFERVLGQG 585

  Fly   751 EFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSN 815
            .||.|..|.|       .|..||:|.|...|::..: :|..|..::.:..|.|:..|.|......
plant   586 GFGKVYHGVL-------NDDQVAVKILSESSAQGYK-EFRAEVELLLRVHHKNLTALIGYCHEGK 642

  Fly   816 PVMIITEYMENGSLDTFLRVNDGKF----QTLQLIVMLRGIASGMSYLSD---MNYVHRDLAARN 873
            .:.:|.|:|.||:|..:|.......    :.||:.:   ..|.|:.||.:   ...|.||:...|
plant   643 KMALIYEFMANGTLGDYLSGEKSYVLSWEERLQISL---DAAQGLEYLHNGCKPPIVQRDVKPAN 704

  Fly   874 VLVNAQLICKIADFGLSREIE---NASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVL 935
            :|:|.:|..|||||||||.:.   |..|.....|   .:.:..||....:|.:..||::|:||||
plant   705 ILINEKLQAKIADFGLSRSVALDGNNQDTTAVAG---TIGYLDPEYHLTQKLSEKSDIYSFGVVL 766

  Fly   936 WEVMSYGE----RPYWNWSNQDVIKSIE--------KGY---RLPAPMDCPEA--LYQLMLDCWQ 983
            .||:| |:    |......|..:...::        :|.   :|....|...|  :.::.:.|..
plant   767 LEVVS-GQPVIARSRTTAENIHITDRVDLMLSTGDIRGIVDPKLGERFDAGSAWKITEVAMACAS 830

  Fly   984 KQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILD 1025
            ....:|||.:.:|:.|      .:|:...|....|..:.:.|
plant   831 SSSKNRPTMSHVVAEL------KESVSRARAGGGSGASSVTD 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	24/158 (15%)
		FN3	387..476	CDD:238020	19/95 (20%)
		FN3	536..623	CDD:238020	16/88 (18%)
		EphA2_TM	644..736	CDD:291255	15/108 (14%)
		PTKc_EphR	736..1002	CDD:270629	79/294 (27%)
		Pkinase_Tyr	741..999	CDD:285015	78/286 (27%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT2G19210	NP_179511.1	Malectin_like	34..357	CDD:289580	80/425 (19%)
		leucine-rich repeat	415..438	CDD:275380	5/48 (10%)
		LRR_8	417..473	CDD:290566	15/89 (17%)
		leucine-rich repeat	439..462	CDD:275380	7/27 (26%)
		leucine-rich repeat	463..488	CDD:275380	2/27 (7%)
		STKc_IRAK	582..848	CDD:270968	77/286 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050