DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and FRK1

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_179509.1 Gene:FRK1 / 816436 AraportID:AT2G19190 Length:876 Species:Arabidopsis thaliana


Alignment Length:1078 Identity:218/1078 - (20%)
Similarity:369/1078 - (34%) Gaps:367/1078 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 VSRMSLLRTILLIIISIHFKLAHA-DQVVLLDTTREATLEWTRYPYGPQAQTPGWV--------E 114
            ::.:..|.:||....::.|.|.|| ||                         .|::        :
plant     1 MAMLKSLSSILFTSFALLFFLVHAQDQ-------------------------SGFISIDCGIPDD 40

  Fly   115 ESFTDFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSL-----FPGNA 174
            .|:.|...||.:    |.|           |.|:|.|:..|:..:.|.:..|..|     ||.:.
plant    41 SSYNDETTGIKY----VSD-----------SAFVDSGTTKRIAAQFQSSGFDRHLLNVRSFPQSK 90

  Fly   175 LSCKETFSLLFYEFDAATREPPPWQTDSYRLIARIAAGE----GR---FNQNSDVDINTEVK--- 229
            .||          :|..|   |..:...|.:..|...|.    ||   |:....|:....||   
plant    91 RSC----------YDVPT---PRGKGFKYLIRTRFMYGNYDDLGRVPEFDLYLGVNFWDSVKLDD 142

  Fly   230 -SIAVNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDN 293
             :..:||:                     .||.| :.:|.          ::.:::|..||    
plant   143 ATTILNKE---------------------IITIP-LLDNV----------QVCVVDKNAGT---- 171

  Fly   294 AEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNAS 358
              |:            .::|.........||..|...|...                   ..:.|
plant   172 --PF------------LSVLEIRLLLNTTYETPYDALTLLR-------------------RLDYS 203

  Fly   359 KTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNL----TLLFVDQ--------TSAIISWSAPA 411
            |||    |..|.:    .|..:...::|....:..    |.|.|||        .|.::|.:..|
plant   204 KTG----KLPSRY----KDDIYDRIWTPRIVSSEYKILNTSLTVDQFLNNGYQPASTVMSTAETA 260

  Fly   412 KNESF-------SSETNSKIY---HSDIVYKIKCN------ICSPNVVYNPS-------TDTF-- 451
            :|||.       ..:.|:|.|   |...:..:|.|      |.....|.:||       ||||  
plant   261 RNESLYLTLSFRPPDPNAKFYVYMHFAEIEVLKSNQTREFSIWLNEDVISPSFKLRYLLTDTFVT 325

  Fly   452 ----NETKITLTNLEPVTTYTVQ--IHAINSVSHINEF----------------------KRHSN 488
                :...|..:.|:|...:.:.  |:|: .|..:|||                      |::..
plant   326 PDPVSGITINFSLLQPPGEFVLPPIINAL-EVYQVNEFLQIPTHPQDVDAMRKIKATYRVKKNWQ 389

  Fly   489 ESSLVAVS------DIVFS----NTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAIT 543
            ....|.|.      |.:.|    |..::::.:..:|:: ||.:..|       |.:.::|.|.::
plant   390 GDPCVPVDYSWEGIDCIQSDNTTNPRVVSLNISFSELR-GQIDPAF-------SNLTSIRKLDLS 446

  Fly   544 NKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKT 608
            ......|                  .|....:..|.:.||.:..|  :.|::..     ::..::
plant   447 GNTLTGE------------------IPAFLANLPNLTELNVEGNK--LTGIVPQ-----RLHERS 486

  Fly   609 NNG-----FGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQD 668
            .||     ||...::..:.:..:......:.    :|...:|.|:  :|:.:.|...|.|.|.:.
plant   487 KNGSLSLRFGRNPDLCLSDSCSNTKKKNKNG----YIIPLVVVGI--IVVLLTALALFRRFKKKQ 545

  Fly   669 DLDKKSTNHLPLPLD---YASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIR 730
            ........:.||...   :..:||             :|:|.                       
plant   546 QRGTLGERNGPLKTAKRYFKYSEV-------------VNITN----------------------- 574

  Fly   731 EFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASI 795
                       ..|.:||.|.||.|..|       .:....||:|.|...|::..: :|..|..:
plant   575 -----------NFERVIGKGGFGKVYHG-------VINGEQVAVKVLSEESAQGYK-EFRAEVDL 620

  Fly   796 MGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTL-----QLIVMLRGIASG 855
            :.:..|.|:..|.|.....|.:::|.|||.|.:|..:|.   ||...:     :|.:.| ..|.|
plant   621 LMRVHHTNLTSLVGYCNEINHMVLIYEYMANENLGDYLA---GKRSFILSWEERLKISL-DAAQG 681

  Fly   856 MSYLSD---MNYVHRDLAARNVLVNAQLICKIADFGLSR--EIENASDAYTTRGGKIPVRWTAPE 915
            :.||.:   ...||||:...|:|:|.:|..|:|||||||  .:|.:....|...|.|  .:..||
plant   682 LEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADFGLSRSFSVEGSGQISTVVAGSI--GYLDPE 744

  Fly   916 AIAFRKFTSASDVWSYGVVLWEVM--------SYGERPYWN------WSNQDVIKSIEKGYRLPA 966
            ..:.|:....|||:|.||||.||:        |..|:.:.:      .:|.|:...:::  ||..
plant   745 YYSTRQMNEKSDVYSLGVVLLEVITGQPAIASSKTEKVHISDHVRSILANGDIRGIVDQ--RLRE 807

  Fly   967 PMDCPEA--LYQLMLDCWQKQRTHRPTFASIVSTLDNL 1002
            ..|...|  :.::.|.|.:.....|||.:.:|..|..:
plant   808 RYDVGSAWKMSEIALACTEHTSAQRPTMSQVVMELKQI 845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 33/198 (17%)
FN3 387..476 CDD:238020 30/131 (23%)
FN3 536..623 CDD:238020 13/91 (14%)
EphA2_TM 644..736 CDD:291255 13/94 (14%)
PTKc_EphR 736..1002 CDD:270629 83/291 (29%)
Pkinase_Tyr 741..999 CDD:285015 82/283 (29%)
SAM_1 1033..1092 CDD:278937
SAM 1039..1092 CDD:197735
FRK1NP_179509.1 Malectin_like 33..358 CDD:289580 84/430 (20%)
leucine-rich repeat 396..415 CDD:275380 4/18 (22%)
leucine-rich repeat 416..439 CDD:275380 5/30 (17%)
leucine-rich repeat 440..463 CDD:275380 4/40 (10%)
leucine-rich repeat 464..479 CDD:275380 4/16 (25%)
STYKc 576..839 CDD:214568 81/278 (29%)
STKc_IRAK 580..845 CDD:270968 82/280 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 138 1.000 Inparanoid score I1804
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.050

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