Protein Alignment Eph and epha5

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_001338064.4
• Gene: epha5 / 797595
• -ID: -
• Length: 983
• Species: Danio rerio
• Alignment Length: 1041
• Identity: 425/1041 - (40%)
• Similarity: 601/1041 - (57%)
• Gaps: 124/1041 - (11%)

  Fly    82 ADQVVLLDT-TREATLEWTRYPYGPQAQTPGW-----VEESFTDFVKGINWRSYVVCDVAYHNVN 140
            |::|.|||: :....|.|..||..      ||     |:|::...      .:|.||.|..||.|
Zfish    26 ANEVNLLDSRSVMGDLGWVAYPKN------GWEEIGEVDENYAPI------HTYQVCKVMEHNQN 78

  Fly   141 NWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRL 205
            |||.:.:|....|.|:::|::||:|||:..||...:|||||::.:||.:...|.  ..:...|..
Zfish    79 NWLQTNWILTQGAQRVFLELKFTLRDCNSLPGGLGTCKETFNVYYYETNDEERR--NIRESQYSK 141

  Fly   206 IARIAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVT 265
            |..|||.|. |.:    :..:.:||||:.:. :.|||.|.||:|.||||::::|:|:|..||.|.
Zfish   142 IDTIAADES-FTELDLGDRVMKLNTEVRDLGPLTKKGFYLAFQDLGACIALVSVRVFYKKCPFVV 205

  Fly   266 ENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNK 330
            .|.|.|.:|.||.:.:.:.:.:||||:|:...|.|...|..:|:|.:..|.|.|:||:|.  .|.
Zfish   206 RNLALFPDTITGADSSQLLEVSGTCVNNSVADELPRMHCSAEGEWLVPIGRCMCQAGHEE--VNG 268

  Fly   331 TCTECPLGTFKSP-EVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLT 394
            :|..|..|.::|. |...|:.|||.|.:....|..|:|..|::|...|..:|.|..||:||.| .
Zfish   269 SCQVCKPGFYRSVLESRSCSKCPPRSFSKVEASISCQCEQGYFRTQADPANMACTRPPSAPRN-A 332

  Fly   395 LLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCN----------ICSPNVVYNPSTD 449
            :..|::||..:.|:||       .:|..:   .|:.|.|.|:          .|..:|.:.|...
Zfish   333 ISNVNETSVFLEWTAP-------EDTGGR---KDVRYNILCSKISTDSGHYEPCGSHVRFLPQRT 387

  Fly   450 TFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNE 514
            ....|.:.:.:|...|.||.::.|:|.||.:....|.       .||..|.:|.:   .|..:..
Zfish   388 GLRNTSVMVVDLLAHTNYTFEVEAMNGVSDLTGPPRQ-------YVSLNVTTNQA---APSPITV 442

  Fly   515 VKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINK 579
            ||.|:.    |..|:.:|                  |.:|.:.:..:..||:::|.|.:  ..:.
Zfish   443 VKKGKT----TKNSITVS------------------WQEPDRPNGIILEYEIKYFEKDQ--ETSY 483

  Fly   580 SALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAI 644
            :.:.:|||:..:.||..::.|.||:|.:|:.|:|.:|.....:|...:.:..:.. |:..||.|:
Zfish   484 TIIKSKETEVLVDGLKPSSAYIFQIRARTSAGYGGFSRRFEFETSPYLAASSEQG-QVPIIAVAV 547

  Fly   645 VTGVLFLVIFIIATVYFMR------SKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHL 703
            ..|:   ::..:.|.:.|.      ||.:.|.|:                          :|:|.
Zfish   548 TVGI---ILIALVTGFLMSGRRCGYSKAKQDPDE--------------------------EKMHF 583

  Fly   704 NVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQ 768
            :.....|.:.|:|:|||||||||||:.|||:|||...||||.:||.||||:||.|.|::|..  :
Zfish   584 HNGHIKFPSVRTYIDPHTYEDPNQAVHEFAKEIDVCCITIERVIGAGEFGEVCSGLLRLPGK--R 646

  Fly   769 DIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFL 833
            :|.|||||||.|.:||.|.|||.||||||||:|||:|:|:||:|:|.||||||||||||||||||
Zfish   647 EIPVAIKTLKAGYTEKQRRDFLGEASIMGQFEHPNIIHLKGVITKSKPVMIITEYMENGSLDTFL 711

  Fly   834 RVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASD 898
            :.|||:|..:||:.|||||||||.|||:|.||||||||||:|||:.|:||::||||||.:|:..:
Zfish   712 KKNDGQFTVIQLVGMLRGIASGMRYLSEMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPE 776

  Fly   899 -AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGY 962
             ||||||||||:|||||||||:|||||||||||||:|:||||||||||||..|||||||::|:.|
Zfish   777 AAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWEMSNQDVIKAVEENY 841

  Fly   963 RLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLL-TTRPSPESDGNHILDG 1026
            |||.|||||.|||.||:|||||.|..||.|..|||.||.|.|.|.||. ...||.......:..|
Zfish   842 RLPGPMDCPTALYHLMMDCWQKDRNSRPKFEEIVSLLDKLIRNPSSLKGLVNPSNRVSNLLVEQG 906

  Fly  1027 QRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQ 1091
            .....:|.|.:.|||.|||.||...|.|:...:.|.::::|.:.|..:|:||.|||||||:..::
Zfish   907 SPEGCVFRSVEEWLEAIKMGRYTELFMESGYTSLQVVTQMTLEDLRRVGVTLAGHQKKILNSIQE 971

  Fly  1092 L 1092
            :
Zfish   972 M 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	66/185 (36%)
		FN3	387..476	CDD:238020	24/98 (24%)
		FN3	536..623	CDD:238020	19/86 (22%)
		EphA2_TM	640..738	CDD:464211	31/103 (30%)
		PTKc_EphR	736..1002	CDD:270629	190/266 (71%)
		SAM_1	1029..1092	CDD:425739	25/62 (40%)
epha5	XP_001338064.4	EphR_LBD_A5	28..200	CDD:198451	66/186 (35%)
		FN3	<323..>551	CDD:442628	64/273 (23%)
		FN3	437..527	CDD:238020	26/113 (23%)
		EphA2_TM	543..618	CDD:464211	31/103 (30%)
		PTKc_EphR_A	616..882	CDD:270651	190/267 (71%)
		SAM_superfamily	913..976	CDD:472832	25/60 (42%)