DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and epha5

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_001338064.4	Gene:	epha5 / 797595	-ID:	-	Length:	983	Species:	Danio rerio

Alignment Length:	1041	Identity:	425/1041 - (40%)
Similarity:	601/1041 - (57%)	Gaps:	124/1041 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 ADQVVLLDT-TREATLEWTRYPYGPQAQTPGW-----VEESFTDFVKGINWRSYVVCDVAYHNVN 140
            |::|.|||: :....|.|..||..      ||     |:|::...      .:|.||.|..||.|
Zfish    26 ANEVNLLDSRSVMGDLGWVAYPKN------GWEEIGEVDENYAPI------HTYQVCKVMEHNQN 78

  Fly   141 NWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRL 205
            |||.:.:|....|.|:::|::||:|||:..||...:|||||::.:||.:...|.  ..:...|..
Zfish    79 NWLQTNWILTQGAQRVFLELKFTLRDCNSLPGGLGTCKETFNVYYYETNDEERR--NIRESQYSK 141

  Fly   206 IARIAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVT 265
            |..|||.|. |.:    :..:.:||||:.:. :.|||.|.||:|.||||::::|:|:|..||.|.
Zfish   142 IDTIAADES-FTELDLGDRVMKLNTEVRDLGPLTKKGFYLAFQDLGACIALVSVRVFYKKCPFVV 205

  Fly   266 ENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNK 330
            .|.|.|.:|.||.:.:.:.:.:||||:|:...|.|...|..:|:|.:..|.|.|:||:|.  .|.
Zfish   206 RNLALFPDTITGADSSQLLEVSGTCVNNSVADELPRMHCSAEGEWLVPIGRCMCQAGHEE--VNG 268

  Fly   331 TCTECPLGTFKSP-EVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLT 394
            :|..|..|.::|. |...|:.|||.|.:....|..|:|..|::|...|..:|.|..||:||.| .
Zfish   269 SCQVCKPGFYRSVLESRSCSKCPPRSFSKVEASISCQCEQGYFRTQADPANMACTRPPSAPRN-A 332

  Fly   395 LLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCN----------ICSPNVVYNPSTD 449
            :..|::||..:.|:||       .:|..:   .|:.|.|.|:          .|..:|.:.|...
Zfish   333 ISNVNETSVFLEWTAP-------EDTGGR---KDVRYNILCSKISTDSGHYEPCGSHVRFLPQRT 387

  Fly   450 TFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNE 514
            ....|.:.:.:|...|.||.::.|:|.||.:....|.       .||..|.:|.:   .|..:..
Zfish   388 GLRNTSVMVVDLLAHTNYTFEVEAMNGVSDLTGPPRQ-------YVSLNVTTNQA---APSPITV 442

  Fly   515 VKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINK 579
            ||.|:.    |..|:.:|                  |.:|.:.:..:..||:::|.|.:  ..:.
Zfish   443 VKKGKT----TKNSITVS------------------WQEPDRPNGIILEYEIKYFEKDQ--ETSY 483

  Fly   580 SALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAI 644
            :.:.:|||:..:.||..::.|.||:|.:|:.|:|.:|.....:|...:.:..:.. |:..||.|:
Zfish   484 TIIKSKETEVLVDGLKPSSAYIFQIRARTSAGYGGFSRRFEFETSPYLAASSEQG-QVPIIAVAV 547

  Fly   645 VTGVLFLVIFIIATVYFMR------SKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHL 703
            ..|:   ::..:.|.:.|.      ||.:.|.|:                          :|:|.
Zfish   548 TVGI---ILIALVTGFLMSGRRCGYSKAKQDPDE--------------------------EKMHF 583

  Fly   704 NVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQ 768
            :.....|.:.|:|:|||||||||||:.|||:|||...||||.:||.||||:||.|.|::|..  :
Zfish   584 HNGHIKFPSVRTYIDPHTYEDPNQAVHEFAKEIDVCCITIERVIGAGEFGEVCSGLLRLPGK--R 646

  Fly   769 DIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFL 833
            :|.|||||||.|.:||.|.|||.||||||||:|||:|:|:||:|:|.||||||||||||||||||
Zfish   647 EIPVAIKTLKAGYTEKQRRDFLGEASIMGQFEHPNIIHLKGVITKSKPVMIITEYMENGSLDTFL 711

  Fly   834 RVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASD 898
            :.|||:|..:||:.|||||||||.|||:|.||||||||||:|||:.|:||::||||||.:|:..:
Zfish   712 KKNDGQFTVIQLVGMLRGIASGMRYLSEMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPE 776

  Fly   899 -AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGY 962
             ||||||||||:|||||||||:|||||||||||||:|:||||||||||||..|||||||::|:.|
Zfish   777 AAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWEMSNQDVIKAVEENY 841

  Fly   963 RLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLL-TTRPSPESDGNHILDG 1026
            |||.|||||.|||.||:|||||.|..||.|..|||.||.|.|.|.||. ...||.......:..|
Zfish   842 RLPGPMDCPTALYHLMMDCWQKDRNSRPKFEEIVSLLDKLIRNPSSLKGLVNPSNRVSNLLVEQG 906

  Fly  1027 QRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQ 1091
            .....:|.|.:.|||.|||.||...|.|:...:.|.::::|.:.|..:|:||.|||||||:..::
Zfish   907 SPEGCVFRSVEEWLEAIKMGRYTELFMESGYTSLQVVTQMTLEDLRRVGVTLAGHQKKILNSIQE 971

  Fly  1092 L 1092
            :
Zfish   972 M 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	66/185 (36%)
		FN3	387..476	CDD:238020	24/98 (24%)
		FN3	536..623	CDD:238020	19/86 (22%)
		EphA2_TM	644..736	CDD:291255	26/97 (27%)
		PTKc_EphR	736..1002	CDD:270629	190/266 (71%)
		Pkinase_Tyr	741..999	CDD:285015	186/258 (72%)
		SAM_1	1033..1092	CDD:278937	25/58 (43%)
		SAM	1039..1092	CDD:197735	23/52 (44%)
epha5	XP_001338064.4	EphR_LBD_A5	28..200	CDD:198451	66/186 (35%)
		FN3	326..432	CDD:238020	31/123 (25%)
		FN3	437..527	CDD:238020	26/113 (23%)
		EphA2_TM	546..616	CDD:291255	27/98 (28%)
		PTKc_EphR_A	616..882	CDD:270651	190/267 (71%)
		Pkinase_Tyr	621..878	CDD:285015	186/258 (72%)
		SAM	908..973	CDD:197735	25/65 (38%)
		SAM_superfamily	913..976	CDD:301707	25/60 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	396	1.000	Domainoid score	I723
eggNOG	1	0.900	-	-		E2759_KOG0196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	753	1.000	Inparanoid score	I540
OMA	1	1.010	-	-		QHG45908
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	1	1.000	-	-		otm24639
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880