DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and epha3

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_001352101.1 Gene:epha3 / 795902 ZFINID:ZDB-GENE-010724-10 Length:981 Species:Danio rerio


Alignment Length:1080 Identity:423/1080 - (39%)
Similarity:601/1080 - (55%) Gaps:162/1080 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 RTILL------IIISIHFKLAHADQVVLLDT-TREATLEWTRYPYGPQAQTPGW-----VEESFT 118
            :|::|      :|.|..|.:..:::|.|||: ..:..|.|...|      :.||     |:|.:|
Zfish     4 KTLILFLFFFTLISSADFIIHPSNEVNLLDSKASQGELGWISSP------SHGWEEISGVDEHYT 62

  Fly   119 DFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSL 183
            ..      |::.||:|..::.||||.:.:|.|.||.::|:|::||:|||:..| ..|:|||||:|
Zfish    63 PI------RTFQVCNVMEYSQNNWLRTNWIPRNSAQKIYVELKFTLRDCNSIP-MVLTCKETFNL 120

  Fly   184 LFYEFDAATREPP--PWQTDSYRLIARIAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVYFA 241
            .:.|    |.|..  .::...:..|..|||.|. |.|    :..:.:||||:.:. :.|||.|.|
Zfish   121 HYLE----TEEDQGNKFREHQFSKIDTIAADES-FTQMDLGDRILKLNTEVREVGPMTKKGFYLA 180

  Fly   242 FRDQGACISVLAVKVYYITCPAVTENFAHFNET-PTGREITIIEKQNGTCVDNAEPYETPTYLCK 305
            |:|.|||:::::|:||:..||....|.|.|.:| ||..: :::|.: |:||:|::..:.|...|.
Zfish   181 FQDVGACVALVSVRVYFKKCPFTVRNLAMFPDTVPTDSQ-SLVEVR-GSCVNNSKEEDPPKMYCS 243

  Fly   306 GDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCAS 369
            .:|:|.:..|.|.|..|||..  ...|..|..|.:| |....||:.|||:|...:.||..|.|..
Zfish   244 TEGEWLVPIGKCLCNIGYEER--GVACQACRPGFYKASSGNVKCSKCPPHSYTHQEGSVHCGCEK 306

  Fly   370 GFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIK 434
            .::|...|...|.|..||:||.|: :..:::||.|:.|:.||.|..          ..|:::.:.
Zfish   307 NYFRADEDPASMACSRPPSAPRNV-ISAINETSVILDWNWPADNGG----------RKDVIFNVV 360

  Fly   435 CNICSPN----------VVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSH----INEFKR 485
            |..|.|.          |.:.|.......|.:|:.:|...|.||.:|.|.|.||.    |.::  
Zfish   361 CKRCWPGPRQCEPCRGAVRFLPRAFGLTNTTVTVADLLAHTNYTFEIEAQNGVSFQAPTIRQY-- 423

  Fly   486 HSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLE 550
                                              |.:..||.....|.|..:|....:.....|.
Zfish   424 ----------------------------------AAVTITTNQAAPSAVTVIRKDRTSRNSISLS 454

  Fly   551 WDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSY 615
            |.:|.:.:..:..|||:::.|.|.:. :.:.|.:|.|...:.||..:|.|..|:|.:|..|:||.
Zfish   455 WMEPERPNGIILDYEVKYYEKQEQET-SYTILRSKGTNVTLNGLKPDTTYLLQIRARTAAGYGSS 518

  Fly   616 SNMIYAQTLQSVGSVYDDSVQIRFIA--GAIVTGVLFLVIFIIATVY--FMRSKHQDDLDKK--- 673
            |.....:|.....|:..::.|:..||  .|:...:|.:|::|:.:.:  :.:|||.|  :|:   
Zfish   519 SRKFEFETSPDSFSISSENSQVVLIAISSAVAIILLTVVLYIVISRFCRYSKSKHPD--EKRLPF 581

  Fly   674 STNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDA 738
            ...||.||                              ..::||||||||||:||:.|||:|:||
Zfish   582 GNGHLRLP------------------------------GIKTYVDPHTYEDPSQAVHEFAKELDA 616

  Fly   739 NYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPN 803
            :.|.|:.::|.||||:||.||||:|..  ::|.|||||||.|.:||.|.|||:||||||||||||
Zfish   617 SSIAIDKVVGAGEFGEVCSGRLKLPSK--KEICVAIKTLKAGYTEKQRRDFLSEASIMGQFDHPN 679

  Fly   804 VIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRD 868
            :|.|:||||||.||||:||||||||||.|||.:|.:|..:||:.|||||||||.|||||.|||||
Zfish   680 IIRLEGVVTRSKPVMIVTEYMENGSLDGFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRD 744

  Fly   869 LAARNVLVNAQLICKIADFGLSREIENASD-AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYG 932
            |||||:|||:.|:||::||||||.:|:..: ||||||||||:|||||||||:|||||||||||||
Zfish   745 LAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYG 809

  Fly   933 VVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVS 997
            :||||||||||||||..|||||||::::|||||.||:||..|||||||||||.|.:||.|..|||
Zfish   810 IVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMECPATLYQLMLDCWQKDRNNRPKFEQIVS 874

  Fly   998 TLDNLARQPQSLLTTRPSPESDGNHILDGQRGQNIFISTDL--------WLEHIKMSRYCHHFKE 1054
            .||.|.|.|.||..|..:.....|.:||..       |||:        |||..:.......|..
Zfish   875 ILDKLIRNPSSLKITASTASRPVNLLLDRN-------STDITSFHTMGDWLESARTLPCKDAFSG 932

  Fly  1055 ANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQLDT 1094
            .:..:...:::.:|:....:|:|:||.||||:.....|:|
Zfish   933 VSYSSCDTLAKTSAEDFKKVGVTIVGPQKKIVSSLTTLET 972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 66/187 (35%)
FN3 387..476 CDD:238020 25/98 (26%)
FN3 536..623 CDD:238020 23/86 (27%)
EphA2_TM 644..736 CDD:291255 27/96 (28%)
PTKc_EphR 736..1002 CDD:270629 191/266 (72%)
Pkinase_Tyr 741..999 CDD:285015 187/258 (72%)
SAM_1 1033..1092 CDD:278937 16/66 (24%)
SAM 1039..1092 CDD:197735 13/52 (25%)
epha3NP_001352101.1 EphR_LBD_A3 28..199 CDD:198449 66/188 (35%)
FN3 324..430 CDD:238020 30/152 (20%)
FN3 435..526 CDD:238020 25/91 (27%)
EphA2_TM 545..614 CDD:317033 28/100 (28%)
PTKc_EphR_A 614..880 CDD:270651 191/267 (72%)
SAM_EPH-A3 910..972 CDD:188943 14/61 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 396 1.000 Domainoid score I723
eggNOG 1 0.900 - - E2759_KOG0196
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 753 1.000 Inparanoid score I540
OMA 1 1.010 - - QHG45908
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm24639
orthoMCL 1 0.900 - - OOG6_100189
Panther 1 1.100 - - O PTHR24416
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1110.970

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