DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and Epha5

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_001162608.1 Gene:Epha5 / 79208 RGDID:620831 Length:1039 Species:Rattus norvegicus


Alignment Length:1087 Identity:435/1087 - (40%)
Similarity:607/1087 - (55%) Gaps:159/1087 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 LRTILLIIISIHFKLAH-ADQVVLLDT-TREATLEWTRYPYGPQAQTPGW-----VEESFTDFVK 122
            |.|.||:..::...||. :::|.|||: |....|.|..:|..      ||     |:|::...  
  Rat    42 LWTCLLLCAALRTLLASPSNEVNLLDSRTVLGDLGWIAFPKN------GWEEIGEVDENYAPI-- 98

  Fly   123 GINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYE 187
                .:|.||.|...|.||||.:.:|....|:|::||::||:|||:..||...:|||||::.::|
  Rat    99 ----HTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFE 159

  Fly   188 FDAAT----REPPPWQTDSYRLIARIAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVYFAFR 243
            .|...    :|      :.|..|..|||.|. |.:    :..:.:||||:.:. ::|||.|.||:
  Rat   160 SDDENGRNIKE------NQYIKIDTIAADES-FTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQ 217

  Fly   244 DQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDG 308
            |.||||::::|:|||..||:|..:.|.|.:|.||.:.:.:.:.:|:||:::...:.|...|..:|
  Rat   218 DVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDDPPKMHCSAEG 282

  Fly   309 KWTILTGGCRCKAGYEPNYTNKTCTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCASGFY 372
            :|.:..|.|.||||||..  |.||..|..|.|| ||....|:.|||:|...:..|..|.|...::
  Rat   283 EWLVPIGKCMCKAGYEEK--NGTCQVCRPGFFKASPHSQTCSKCPPHSYTHEEASTSCVCEKDYF 345

  Fly   373 RHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI---K 434
            |..:|...|.|..||:||.| .:..|::||..:.|..||       :|..:   .|:.|.|   |
  Rat   346 RRESDPPTMACTRPPSAPRN-AISNVNETSVFLEWIPPA-------DTGGR---KDVSYYIACKK 399

  Fly   435 CNI-------CSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSL 492
            ||.       |..:|.|.|.......|.:.:.:|...|.||.:|.|:|.||              
  Rat   400 CNSHAGVCEECGGHVRYLPQQIGLKNTSVMMADLLAHTNYTFEIEAVNGVS-------------- 450

  Fly   493 VAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQS 557
                              ||:........:..||.....|.|.|::...|......|.|.:|.:.
  Rat   451 ------------------DLSPGTRQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRP 497

  Fly   558 DFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQ 622
            :..:..||:::|.|.:  ..:.:.:.:|||.....||...:.|.||:|.:|..|:|.:|.....:
  Rat   498 NGIILEYEIKYFEKDQ--ETSYTIIKSKETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFE 560

  Fly   623 TLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFI---------------------------IATVY 660
            | ..|.:..:|..||..||.::..||:.|.:.|                           |....
  Rat   561 T-TPVFAASNDQSQIPIIAVSVTVGVILLAVMIGFLLSGSCCECGCGRASSLCAVAHPSLIWRCG 624

  Fly   661 FMRSKHQDDLDKK---STNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTY 722
            :.::| ||..::|   ...|:.||                              ..|:|:|||||
  Rat   625 YSKAK-QDPEEEKMHFHNGHIKLP------------------------------GVRTYIDPHTY 658

  Fly   723 EDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARC 787
            |||.||:.|||:||:|:.||||.:||.||||:||.||||:|..  :::.|||||||.|.:||.|.
  Rat   659 EDPTQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGK--RELPVAIKTLKVGYTEKQRR 721

  Fly   788 DFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGI 852
            |||:||||||||||||:|:|:||||:|.||||:|||||||||||||:.|||:|..:||:.|||||
  Rat   722 DFLSEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGI 786

  Fly   853 ASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASD-AYTTRGGKIPVRWTAPEA 916
            |:||.|||||.||||||||||:|:|:.|:||::||||||.:|:..: ||||||||||:|||||||
  Rat   787 AAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEA 851

  Fly   917 IAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDC 981
            ||||||||||||||||:|:|||:||||||||..:||||||::|:|||||:|||||.|||||||||
  Rat   852 IAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDC 916

  Fly   982 WQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILD-GQRGQNIFISTDLWLEHIKM 1045
            |||.|..||.|..||:.||.|.|.|.||.|...:.......:.: |..|...:.|...|||.|||
  Rat   917 WQKDRNSRPKFDDIVNMLDKLIRNPSSLKTLVNASSRVSTLLAEHGSLGSGAYRSVGEWLEAIKM 981

  Fly  1046 SRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQL 1092
            .||...|.|....:...::::|.:.|..:|:|||||||||::..:::
  Rat   982 GRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEM 1028

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 67/189 (35%)
FN3 387..476 CDD:238020 28/98 (29%)
FN3 536..623 CDD:238020 22/86 (26%)
EphA2_TM 644..736 CDD:291255 27/121 (22%)
PTKc_EphR 736..1002 CDD:270629 192/266 (72%)
Pkinase_Tyr 741..999 CDD:285015 188/258 (73%)
SAM_1 1033..1092 CDD:278937 23/58 (40%)
SAM 1039..1092 CDD:197735 22/52 (42%)
Epha5NP_001162608.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
EphR_LBD 62..234 CDD:295439 67/190 (35%)
FN3 360..466 CDD:238020 33/148 (22%)
FN3 471..561 CDD:238020 24/91 (26%)
EphA2_TM 580..672 CDD:291255 27/122 (22%)
PTKc_EphR_A 672..938 CDD:270651 192/267 (72%)
Pkinase_Tyr 677..934 CDD:285015 188/258 (73%)
SAM_EPH-A5 967..1032 CDD:188945 23/62 (37%)
SAM 971..1029 CDD:197735 23/58 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 399 1.000 Domainoid score I718
eggNOG 1 0.900 - - E2759_KOG0196
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 763 1.000 Inparanoid score I521
OMA 1 1.010 - - QHG45908
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm46382
orthoMCL 1 0.900 - - OOG6_100189
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X82
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.880

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