DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and TEK

DIOPT Version :10

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_000450.3 Gene:TEK / 7010 HGNCID:11724 Length:1124 Species:Homo sapiens


Alignment Length:1019 Identity:244/1019 - (23%)
Similarity:379/1019 - (37%) Gaps:305/1019 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 PYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYH------------NVNNWLWSPFIDRGSAN 154
            |||....| ||         ||:.      |:.|.|            :.||   ....||    
Human   284 PYGCSCAT-GW---------KGLQ------CNEACHPGFYGPDCKLRCSCNN---GEMCDR---- 325

  Fly   155 RLYIEIQFTIRDCSLFPG-NALSCKETFSLLFYEFDAATREPPPWQTDSYRLIARIAAGEGRFN- 217
                     .:.|...|| ..|.|         |.:...|..|    ....|...|....|:|| 
Human   326 ---------FQGCLCSPGWQGLQC---------EREGIQRMTP----KIVDLPDHIEVNSGKFNP 368

  Fly   218 ----------QNSDV-------------DIN-TEVKSIAVNKKGVYFAFR-----DQG--AC--- 248
                      .|.::             |.| |:..|:|:      |...     |.|  .|   
Human   369 ICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAI------FTIHRILPPDSGVWVCSVN 427

  Fly   249 -ISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDG---- 308
             ::.:..|.:.|:...:.:.....|...||....:|.       .::|||       .|||    
Human   428 TVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVIN-------ISSEPY-------FGDGPIKS 478

  Fly   309 KWTILTGGCRCKAGYEP----------NYTNKTCTECPLGTFKSPEVTKCTPCPPNSNASKTGSP 363
            |          |..|:|          ..||:..|                   .|....:|...
Human   479 K----------KLLYKPVNHYEAWQHIQVTNEIVT-------------------LNYLEPRTEYE 514

  Fly   364 FC----KCASGFYRHPNDGRHMPCYS---PPAAPTNLTLLFVDQTSAIISWSA--PAKNESFSSE 419
            .|    :...|...||...|.....|   ||  |..|.||...||:..::|..  |:..:.|..|
Human   515 LCVQLVRRGEGGEGHPGPVRRFTTASIGLPP--PRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVE 577

  Fly   420 TNSK-IYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEF 483
            ...: :..||     :.||..|.          |.|.:.|.||.|...|.|:       :.:|..
Human   578 VERRSVQKSD-----QQNIKVPG----------NLTSVLLNNLHPREQYVVR-------ARVNTK 620

  Fly   484 KRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDAD 548
            .:......|.|.:               |:::...|.|              |::|..||:..|.
Human   621 AQGEWSEDLTAWT---------------LSDILPPQPE--------------NIKISNITHSSAV 656

  Fly   549 LEWDKPVQSDFPLEFYEVRWFPKV----ELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTN 609
            :.|  .:...:.:....:|:  ||    |...::....|...|:..:.||...|.|  ||.....
Human   657 ISW--TILDGYSISSITIRY--KVQGKNEDQHVDVKIKNATITQYQLKGLEPETAY--QVDIFAE 715

  Fly   610 NGFGSYSNMIYAQTLQSV-----------GSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMR 663
            |..|| ||..::..|.::           |.:    :.|..:..|.:|.:..|:.|:| .:...|
Human   716 NNIGS-SNPAFSHELVTLPESQAPADLGGGKM----LLIAILGSAGMTCLTVLLAFLI-ILQLKR 774

  Fly   664 SKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQA 728
            :..|..:.:...|....|    :.:.|| .|..:.:|:..|            .||..|.     
Human   775 ANVQRRMAQAFQNVREEP----AVQFNS-GTLALNRKVKNN------------PDPTIYP----- 817

  Fly   729 IREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQD---IDVAIKTLKPGSSEKARCDFL 790
                  .:|.|.|..:.:||.|.||.|.:.|:|      :|   :|.|||.:|..:|:....||.
Human   818 ------VLDWNDIKFQDVIGEGNFGQVLKARIK------KDGLRMDAAIKRMKEYASKDDHRDFA 870

  Fly   791 TEASIMGQF-DHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLR------------VNDGKFQT 842
            .|..::.:. .|||:|.|.|.......:.:..||..:|:|..|||            :.:....|
Human   871 GELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTAST 935

  Fly   843 L---QLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRG 904
            |   ||:.....:|.||.|||...::||||||||:||....:.|||||||||    ..:.|..:.
Human   936 LSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR----GQEVYVKKT 996

  Fly   905 -GKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPM 968
             |::||||.|.|::.:..:|:.||||||||:|||::|.|..||...:..::.:.:.:||||..|:
Human   997 MGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061

  Fly   969 DCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTT 1012
            :|.:.:|.||..||:::...||:||.|:.:|:.:..:.::.:.|
Human  1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNT 1105

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 39/206 (19%)
FN3 387..476 CDD:238020 24/91 (26%)
FN3 536..623 CDD:238020 23/90 (26%)
EphA2_TM 640..738 CDD:464211 17/97 (18%)
PTKc_EphR 736..1002 CDD:270629 104/285 (36%)
SAM_1 1029..1092 CDD:425739
TEKNP_000450.3 Ig_Tie2_1 24..118 CDD:463089
EGF_Lam 230..275 CDD:238012
EGF_Lam 314..>342 CDD:238012 9/52 (17%)
IgI_Tie2 348..439 CDD:409556 17/100 (17%)
Ig strand A 348..352 CDD:409556 1/7 (14%)
Ig strand A' 358..362 CDD:409556 1/3 (33%)
Ig strand B 365..374 CDD:409556 2/8 (25%)
Ig strand C 382..387 CDD:409556 0/4 (0%)
Ig strand C' 391..393 CDD:409556 0/1 (0%)
Ig strand D 397..401 CDD:409556 2/3 (67%)
Ig strand E 404..412 CDD:409556 3/13 (23%)
Ig strand F 420..428 CDD:409556 2/7 (29%)
Ig strand G 431..439 CDD:409556 1/7 (14%)
fn3 445..520 CDD:394996 20/117 (17%)
fn3 544..626 CDD:394996 26/105 (25%)
FN3 639..731 CDD:238020 26/112 (23%)
PTKc_Tie2 816..1118 CDD:133219 106/311 (34%)
Blue background indicates that the domain is not in the aligned region.

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