Protein Alignment Eph and Ephb4

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_003751205.1
• Gene: Ephb4 / 686310
• RGDID: 1583193
• Length: 996
• Species: Rattus norvegicus
• Alignment Length: 1045
• Identity: 423/1045 - (40%)
• Similarity: 599/1045 - (57%)
• Gaps: 110/1045 - (10%)

  Fly    79 LAHADQVVLLDTTRE-ATLEWTRYPYGPQAQTPG-WVEESFTDFVKGINWRSYVVCDVAYHNVN- 140
            ||.|.:..||:|..| |.|:|..||     |..| |.|.|..| .:..:.|:|.|||:......
  Rat    12 LATALEETLLNTKLETADLKWVTYP-----QAEGQWEELSGLD-EEQHSVRTYEVCDMKRPGGQA 70

  Fly   141 NWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFY--EFDAATREPPPWQTDSY 203
            :||.:.::.|..|..:|..|:||:.:|...|..:.||||||::.:|  |.|.||...|.|..:.|
  Rat    71 HWLRTGWVPRRGAVHVYATIRFTMMECLSLPRASRSCKETFTVFYYESEADTATAHTPAWMENPY 135

  Fly   204 RLIARIAAGE-GRFNQNSDVDINTEVKSI---AVNKKGVYFAFRDQGACISVLAVKVYYITCPAV 264
            ..:..:||.. .|....::......:|::   .::|.|.|.||:|||||:::|::.::|..|..:
  Rat   136 IKVDTVAAEHLTRKRPGAEATGKVNIKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCSRL 200

  Fly   265 TENFAHFNETPTGREITIIEKQNGTCVDNAEP--YETPTYLCKGDGKWT-ILTGGCRCKAGYEPN 326
            ..|..:|.|| ..||:.:  ...|:||.||.|  ..:|:..|:.||:|. ....||.|..|||..
  Rat   201 VTNLTYFPET-VPRELVV--PVAGSCVANAVPTASPSPSLYCREDGQWAEQQVTGCSCAPGYEAA 262

  Fly   327 YTNKTCTECPLGTFKSPEVTK--CTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAA 389
            ..||.|..|..|||| |::.:  |.|||.||:::..|||.|.|..|:||..:|.|..||.:||:|
  Rat   263 EGNKVCRACGQGTFK-PQIGEEPCLPCPANSHSNNIGSPVCLCRIGYYRARSDPRSSPCTTPPSA 326

  Fly   390 PTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSP---------NVVYN 445
            |.:: :..::.:|..:.||||.  ||...|        |:.|.::|..|.|         ::.::
  Rat   327 PRSV-VHHLNGSSLRLEWSAPL--ESGGRE--------DLTYAVRCRECRPGGSCLPCGGDLTFD 380

  Fly   446 PSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPL 510
            |......|..:.:..|.|..|||.::.|:|.|             |.:|.....|..   :|:..
  Rat   381 PGPRDLVEPWVAIRGLRPDVTYTFEVAALNGV-------------STLATGPPPFEP---VNVTT 429

  Fly   511 DLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELD 575
            | .|.:||     |.:.:| ...|.::|:...:.....|.|..|......:..|||::..|....
  Rat   430 D-REGRTG-----FLSPAV-PPAVSDIRVTRSSPSSLILSWAIPRAPSGAVLDYEVKYHEKGAEG 487

  Fly   576 AINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFI 640
            ..:...|.|.|.:|.:.||.:...|..|||.::..|:|.:....::||.......:.:  |:..|
  Rat   488 PSSVRFLKTSENRAELRGLKQGASYLVQVRARSEAGYGPFGQEHHSQTQLDESESWRE--QLALI 550

  Fly   641 AGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNV 705
            ||..|.||:.:::.||..|..:|        |:|:..   .::|:......
  Rat   551 AGTAVVGVVLVLVVIIIAVLCLR--------KQSSGR---EVEYSDKHGQY-------------- 590

  Fly   706 TTPLFGN-SRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQD 769
               |.|: ::.|:||.||||||:|:||||:|||.:|:.||.:||.||||:|||||||.|..  ::
  Rat   591 ---LIGHGTKVYIDPFTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGK--KE 650

  Fly   770 IDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLR 834
            ..|||||||.|.:|:.|.:||:||||||||:|||:|.|:||||.|.||||:||:||||:||:|||
  Rat   651 SCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLR 715

  Fly   835 VNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREI-ENASD 898
            :|||:|..:||:.|||||||||.||::|:||||||||||:|||:.|:||::||||||.: ||:||
  Rat   716 LNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSD 780

  Fly   899 -AYTTR-GGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKG 961
             .||:. |||||:||||||||||||||||||.||||:|:|||||:||||||:.||||||.:||:.
  Rat   781 PTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQD 845

  Fly   962 YRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSL-LTTRPSPESDG-NHIL 1024
            ||||.|.|||.:|:|||||||||.|..||.|..:||.||.:.|.|.|| :..|   |:.| :|.|
  Rat   846 YRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVAR---ENGGASHPL 907

  Fly  1025 DGQR--GQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILH 1087
            ..||  ..:.|.|...||..|||.||...|..|...:.:.:|:::|:.|..:|:||.|||||||.
  Rat   908 LDQRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFEVVSQISAEDLLRIGVTLAGHQKKILA 972

  Fly  1088 QARQL 1092
            ..:.:
  Rat   973 SVQHM 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	60/183 (33%)
		FN3	387..476	CDD:238020	24/97 (25%)
		FN3	536..623	CDD:238020	20/86 (23%)
		EphA2_TM	640..738	CDD:464211	31/98 (32%)
		PTKc_EphR	736..1002	CDD:270629	183/268 (68%)
		SAM_1	1029..1092	CDD:425739	24/62 (39%)
Ephb4	XP_003751205.1	EphR_LBD_B4	17..196	CDD:198442	60/184 (33%)
		FN3	324..429	CDD:238020	30/131 (23%)
		fn3	444..527	CDD:394996	21/82 (26%)
		EphA2_TM	<573..621	CDD:464211	22/75 (29%)
		PTKc_EphR_B	619..887	CDD:173638	183/269 (68%)
		SAM_EPH-B4	916..982	CDD:188953	24/62 (39%)