DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eph and csf1ra

DIOPT Version :10

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_571747.1 Gene:csf1ra / 64274 ZFINID:ZDB-GENE-001205-1 Length:977 Species:Danio rerio


Alignment Length:973 Identity:207/973 - (21%)
Similarity:328/973 - (33%) Gaps:347/973 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   288 GTCV--DNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVTKCT- 349
            ||.|  ::..|.:   .:|:|||..|.|.     :......|.:|     .:|..:|..|.|.| 
Zfish    33 GTDVILESGSPLQ---LVCEGDGPVTFLP-----RLAKHKRYISK-----EVGKIRSFRVEKTTV 84

  Fly   350 ------PC----PPNSNASKTGSPFCKCASGFYRHPN--------DGRH--MPCY---------- 384
                  .|    ..:||.|.:...|.:.:...:..|:        :|..  :||.          
Zfish    85 DFTGTYKCVYMNGNDSNLSSSVHVFVRDSRVLFVSPSTSLRYVRKEGEDLLLPCLLTDPEATDFT 149

  Fly   385 ----SPPAAPTNLTLLFVDQTSAIISWSAPAKNESF-------SSETNSKIYHSDIVYK------ 432
                :..|||..:.:.:..:...:|....|..|..:       .:|..|||:..:|:.:      
Zfish   150 FRMDNGSAAPYGMNITYDPRKGVLIRNVHPGFNADYICCARIGGAEKVSKIFSINIIQRLRFPPY 214

  Fly   433 -----------------IKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHI 480
                             |.|...:||..||.   |:..:...|...|..:|......||.|:   
Zfish   215 VYLKRNEYVKLVGERLQISCTTNNPNFYYNV---TWTHSSRMLPKAEEKSTMEGDRLAIESI--- 273

  Fly   481 NEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEI---VFTTE-----------SVLL 531
                        :.:..:..|:|.        |...|||.|.   ..||:           |..|
Zfish   274 ------------LTIPSVQLSHTG--------NITCTGQNEAGANSSTTQLLVVEEPYIRLSPKL 318

  Fly   532 STVFNLRILAI---TNKDADL-------------EWDKPVQSDFPLEFYEVRWF----------- 569
            |:....|.|:|   ...|.||             :|:.|...:..|.  |.|:|           
Zfish   319 SSKLTHRGLSIEVSEGDDVDLGVLIEAYPPLTSHKWETPTSHNASLP--ENRFFNHNDRYEALLL 381

  Fly   570 -PKVELDAINKSALNTKET--------------------KAHIVGLLENTEYGF----------- 602
             .::..:.|.:..||.|.:                    |...|..|....||:           
Zfish   382 LKRLNFEEIGQYTLNVKNSMKSASITFDIKMYTKPVARVKWENVTTLSCRSYGYPAPSILWYQCT 446

  Fly   603 --QVRCKTNNGFGSYSNMIYAQTL----QSVGSV------------------------------- 630
              :..|..|.   :....|..||:    :|.|:|                               
Zfish   447 GIRTTCPENT---TDLQPIQTQTVEFQKESFGAVGVESVLTVGPNRRMTVVCVAFNLVGQGSDTF 508

  Fly   631 ---YDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKK---STNHLPLPLDYASNEV 689
               ..|.:....:.|:.|..|: |.:.:|..:|..:.|.:.::..|   :||             
Zfish   509 SMEVSDQIFTSAMCGSTVAMVV-LGLLLIFMIYKYKQKPRYEIRWKIIEATN------------- 559

  Fly   690 NSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGD 754
                                 ||:.:::||  .:.|.....||.|:    .:.:...:|.|.||.
Zfish   560 ---------------------GNNYTFIDP--TQLPYNEKWEFPRD----KLKLGKTLGAGAFGK 597

  Fly   755 VCRGR---LKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQF-DHPNVIYLQGVVTRSN 815
            |....   |....|..:   ||:|.||..:....|...::|..|:... .|.|::.|.|..|...
Zfish   598 VVEATAYGLGKEDNITR---VAVKMLKASAHPDEREALMSELKILSHLGQHKNIVNLLGACTHGG 659

  Fly   816 PVMIITEYMENGSLDTFLRVNDGKFQTLQLIV--------------------------------- 847
            ||::||||..:|.|..|||.....|....:.:                                 
Zfish   660 PVLVITEYCCHGDLLNFLRSKAENFLNFVMTIPNFPEPMTDYKNVSTERMFVRSDSGISSTCSDH 724

  Fly   848 ---------------------------------MLR---GIASGMSYLSDMNYVHRDLAARNVLV 876
                                             :||   .:|.|:.:|:..|.:|||:||||||:
Zfish   725 YLDMRPVTSRPTNSALDSSSECQEDSWPLDMDDLLRFSSQVAQGLDFLAAKNCIHRDVAARNVLL 789

  Fly   877 NAQLICKIADFGLSREIENASDAYTTRG-GKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMS 940
            ....:.||.||||:|:|.|.|: |..:| .::||:|.|||:|....:|..|||||||::|||:.|
Zfish   790 TNSRVAKICDFGLARDIMNDSN-YVVKGNARLPVKWMAPESIFECVYTVQSDVWSYGIMLWEIFS 853

  Fly   941 YGERPYWN-WSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNL 1002
            .|:.||.| ..:....|.|:.||::..|...|..:|.:|..||......||||:.|...:..:
Zfish   854 LGKSPYPNILVDSKFYKMIKCGYQMSRPDFAPPEMYTIMKMCWNLDAAERPTFSKISQMIQRM 916

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439
FN3 387..476 CDD:238020 23/118 (19%)
FN3 536..623 CDD:238020 24/147 (16%)
EphA2_TM 640..738 CDD:464211 18/100 (18%)
PTKc_EphR 736..1002 CDD:270629 97/340 (29%)
SAM_1 1029..1092 CDD:425739
csf1raNP_571747.1 Ig_2 41..110 CDD:464026 18/81 (22%)
IG_like 126..200 CDD:214653 11/73 (15%)
Ig 226..306 CDD:472250 22/105 (21%)
Ig strand B 230..234 CDD:409551 1/3 (33%)
Ig strand C 244..248 CDD:409551 2/6 (33%)
Ig strand E 272..276 CDD:409551 1/18 (6%)
Ig strand F 286..291 CDD:409551 1/4 (25%)
Ig strand G 299..302 CDD:409551 0/2 (0%)
Ig 311..410 CDD:472250 19/100 (19%)
Ig strand B 337..341 CDD:409364 2/3 (67%)
Ig strand C 351..354 CDD:409364 0/2 (0%)
Ig strand E 378..382 CDD:409364 0/3 (0%)
Ig strand F 392..397 CDD:409364 1/4 (25%)
Ig strand G 405..408 CDD:409364 0/2 (0%)
Regulatory juxtamembrane domain. /evidence=ECO:0000250 544..576 9/67 (13%)
PTKc_CSF-1R 545..918 CDD:133237 109/416 (26%)
Activation loop. /evidence=ECO:0000250 799..821 10/22 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 919..977
Blue background indicates that the domain is not in the aligned region.

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