Protein Alignment Eph and epha4a

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_005171372.1
• Gene: epha4a / 64271
• ZFINID: ZDB-GENE-001207-7
• Length: 1034
• Species: Danio rerio
• Alignment Length: 1098
• Identity: 443/1098 - (40%)
• Similarity: 600/1098 - (54%)
• Gaps: 165/1098 - (15%)

  Fly    67 TILLII----ISIHFKLAHADQVVLLDT-TREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINW 126
            |..|||    .::..::...::|.|||: |.:..|:|...|     ...||.|.|..| .|....
Zfish    12 TFALIIWIPTFALTARVYPPNEVTLLDSRTVQGELKWVASP-----TEGGWEEVSIMD-EKNTPI 70

  Fly   127 RSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEF--- 188
            |:|.||:|...:.||||.:.:|.||.|.|:||||:||:|||:..||...:|||||:|.:||.
Zfish    71 RTYQVCNVMEPSQNNWLRTDWIPRGGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESNND 135

  Fly   189 -DAATREPPPWQTDSYRLIARIAAGEGRFNQNSDVDI-------NTEVKSIAV-NKKGVYFAFRD 244
             :...||      :.:..|..|||.|. |.|   |||       ||||:.:.: .:||.|.||:|
Zfish   136 KERYIRE------NQFTKIDTIAADES-FTQ---VDIGDRIMKLNTEVRDVGILTRKGFYLAFQD 190

  Fly   245 QGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGK 309
            .||||::::|:::|..||....|.|.|.:|.||.:.:.:.:..|:||||:|..|.|...|..||:
Zfish   191 VGACIALVSVRIFYKKCPLTVRNLAQFPDTTTGADTSSLVEVRGSCVDNSEEREVPKMYCGADGE 255

  Fly   310 WTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVT-KCTPCPPNSNASKTGSPFCKCASGFYR 373
            |.:..|.|.|..|||.:  ..||..|.:|.:::.... .|:.||.:|.:.:.||..|.|..||:|
Zfish   256 WLVPIGNCLCNPGYEEH--EGTCQACKIGNYRALATDGSCSKCPLHSYSVREGSTSCACDKGFFR 318

  Fly   374 HPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNIC 438
            ...|...|||..||:||.:| :..|::||..:.|:|||.:..          ..|:.|.:.|..|
Zfish   319 SETDPASMPCTQPPSAPQHL-ISNVNETSVNLEWTAPASSGG----------RQDLAYNVICKRC 372

  Fly   439 SPN----------VVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLV 493
            |.:          :.::|.......|::::.:|:..|.||.:|.|:|.||     |:.......|
Zfish   373 SSDGQRCQPCGNGIHFSPQQLGLRTTRVSINDLQAHTNYTFEIWAVNGVS-----KQSPGPEQAV 432

  Fly   494 AVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSD 558
            :|:                           .||.....|.|..::...||.....|.|.:|.:.:
Zfish   433 SVT---------------------------VTTNQAAPSPVTTIQAKDITRHAVSLAWQQPERPN 470

  Fly   559 FPLEFYEVRWFPKVELDAINKS--ALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYA 621
            ..:..|||:::.|   |...:|  .:.|....|.|.||...|.|.|.||.:|..|:|.:|.....
Zfish   471 GVILEYEVKYYEK---DQNERSYRIMKTSSRSAEIKGLSPLTSYVFHVRARTAAGYGEFSAPFEF 532

  Fly   622 QTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYAS 686
            .|......:..|......:..:::..|:.|:|||...:...|...............||...|..
Zfish   533 MTNSVPSPIIGDGANSTVLLVSVIGSVILLLIFIGVFIISRRQVTPSSAGSLGLRQCPLWCCYPF 597

  Fly   687 NEVNSMDTTPIVKK----------------LHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFARE 735
            :..:|: |.|..::                ||..|        |.||||.||||||||:||||:|
Zfish   598 HCFSSV-TCPHTERRSKYSKAKQDSDEERHLHPGV--------RIYVDPFTYEDPNQAVREFAKE 653

  Fly   736 IDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFD 800
            |||:.|.||.:||.||||:||.||||:|..  ::|.|||||||.|.::|.|.|||:|||||||||
Zfish   654 IDASCIKIEKVIGIGEFGEVCSGRLKMPGK--REICVAIKTLKAGYTDKQRRDFLSEASIMGQFD 716

  Fly   801 HPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYV 865
            |||:|.|:||||:..|||||||||||||||.|||.|||:|..:||:.:||||||||.|||||:||
Zfish   717 HPNIIRLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGILRGIASGMKYLSDMSYV 781

  Fly   866 HRDLAARNVLVNAQLICKIADFGLSREIENASD-AYTTR---------GGKIPVRWTAPEAIAFR 920
            ||||||||:|||:.|:||::|||:||.:|...| |||||         |||||:||||||||.:|
Zfish   782 HRDLAARNILVNSNLVCKVSDFGMSRVLEEDPDAAYTTREITGTYQSQGGKIPIRWTAPEAITYR 846

  Fly   921 KFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQ 985
            ||||||||||||:|:||||||||||||:.|||||||:||:|||||.|||||.:|:|||||||||:
Zfish   847 KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPVSLHQLMLDCWQKE 911

  Fly   986 RTHRPTFASIVSTLDNLARQPQSLLTT-----RP--------SPESDGNHILDGQRGQNIFIST- 1036
            |..||.|:.||:.||.|.|.|.||..|     ||        |||               |.||
Zfish   912 RAERPKFSQIVNMLDKLIRNPNSLKRTGGEIARPNTTLLEPSSPE---------------FTSTL 961

  Fly  1037 ----DLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQAR 1090
                | ||:.|.|.||..:|..|.....:.:..:|.:.::.:||:...||.|||:.|:
Zfish   962 GSVAD-WLQAINMERYRDNFTAAGYTTPEAVVHMTQEDMTRIGISTAAHQDKILNSAQ 1018

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	75/187 (40%)
		FN3	387..476	CDD:238020	24/98 (24%)
		FN3	536..623	CDD:238020	25/88 (28%)
		EphA2_TM	640..738	CDD:464211	34/113 (30%)
		PTKc_EphR	736..1002	CDD:270629	192/275 (70%)
		SAM_1	1029..1092	CDD:425739	21/67 (31%)
epha4a	XP_005171372.1	EphR_LBD_A4	33..206	CDD:198450	75/188 (40%)
		FN3	<311..>564	CDD:442628	72/298 (24%)
		FN3	443..534	CDD:238020	27/93 (29%)
		EphA2_TM	553..656	CDD:464211	34/111 (31%)
		PTKc_EphR_A	654..929	CDD:270651	192/276 (70%)
		SAM_EPH-A4	959..1029	CDD:188944	20/61 (33%)