Protein Alignment Eph and Epha8

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_001406194.1
• Gene: Epha8 / 60589
• RGDID: 708543
• Length: 1004
• Species: Rattus norvegicus
• Alignment Length: 1048
• Identity: 409/1048 - (39%)
• Similarity: 572/1048 - (54%)
• Gaps: 138/1048 - (13%)

  Fly    84 QVVLLDT-TREATLEWTRYPYGPQAQTPGW-----VEESFTDFVKGINWRSYVVCDVAYHNVNNW 142
            :|.|||| |......|..||      ..||     |:|||...      .:|.||:|...|.|||
  Rat    30 EVNLLDTSTIHGDWGWLTYP------AHGWDSINEVDESFRPI------HTYQVCNVMSPNQNNW 82

  Fly   143 LWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFD----AATREPPPWQTDSY 203
            |.:.::.|..|.|:|.||:||:|||:..||...:|||||:|.:.|.|    |:|:|      ..:
  Rat    83 LRTSWVPRDGARRVYAEIKFTLRDCNSIPGVLGTCKETFNLHYLESDRDLGASTQE------SQF 141

  Fly   204 RLIARIAAGEGRFNQNSDV---DINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAV 264
            ..|..|||.|.....:..|   .:||||:.:. ::|:|.|.||:|.|||:::|::::||..|||:
  Rat   142 LKIDTIAADESFTGADLGVRRLKLNTEVRGVGPLSKRGFYLAFQDIGACLAILSLRIYYKKCPAM 206

  Fly   265 TENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTN 329
            ..|.|.|:|..||.:.:.:.:..|.||.::|..:||...|..:|:|.:..|.|.|.||||..  .
  Rat   207 VRNLAAFSEAVTGADSSSLVEVRGQCVRHSEERDTPKMYCSAEGEWLVPIGKCVCSAGYEER--R 269

  Fly   330 KTCTECPLGTFKS-PEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNL 393
            ..|..|.||.:|| |....|..|||:|:::...:..|:|...:||...|.....|..||:||.||
  Rat   270 DACMACELGFYKSAPGDQLCARCPPHSHSATPAAQTCRCDLSYYRAALDPPSAACTRPPSAPVNL 334

  Fly   394 TLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI----------KCNICSPNVVYNPST 448
             :..|:.||..:.|:.|.....          .|||.|..          .|..|.....:.|..
  Rat   335 -ISSVNGTSVTLEWAPPLDPGG----------RSDITYNAVCRRCPWALSHCEACGSGTRFVPQQ 388

  Fly   449 DTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLN 513
            .:..:..:.:.||.....|:..|.|:|.||:::...|                |.:::||
  Rat   389 TSLAQASLLVANLLAHMNYSFWIEAVNGVSNLSPEPR----------------NAAVVNI----- 432

  Fly   514 EVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAIN 578
                       ||.....|.|..:|..........|.|.:|.|.:..:..||::::.| :.:..:
  Rat   433 -----------TTNQAAPSQVVVIRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEK-DKEMQS 485

  Fly   579 KSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSV---YDDSVQIRFI 640
            .|.|....|:|.:.||...|.|.||||.:|:.|.|.:|..:..:|    |..   ||... |.:|
  Rat   486 YSTLKAVTTRATVSGLKPGTRYMFQVRARTSAGCGRFSQAMEVET----GKPRPRYDTRT-IVWI 545

  Fly   641 AGAIVTGVLFLVIFIIATVYFMRSKH-------QDDLDKKSTNHLPLPLDYASNEVNSMDTTPIV 698
            ...::||::.|::.:|.     :.:|       ||..::|        :.|.    |.....|:.
  Rat   546 CLTLITGLVVLLLLLIC-----KKRHCGYSKAFQDSDEEK--------MHYQ----NGQAPPPVF 593

  Fly   699 KKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIP 763
              |.||........::...:||.||:|.:|.|.|.|||:|:.|.||.|||.||.|:||.|||::|
  Rat   594 --LPLNHPPGKLPETQFSAEPHNYEEPGRAGRSFTREIEASRIHIEKIIGSGESGEVCYGRLQVP 656

  Fly   764 PNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGS 828
            ..  :|:.||||.||.|.:|:.|.|||.||:|||||||||:|.|:|||||....||:||||||||
  Rat   657 GQ--RDVPVAIKALKAGYTERQRQDFLREAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGS 719

  Fly   829 LDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREI 893
            ||.|||.:||:|..|||:.||:|:.:||.||||:.|:||||||||:||:.:|:||::||||||.:
  Rat   720 LDAFLRTHDGQFTILQLVGMLKGVGAGMRYLSDLGYIHRDLAARNILVDGRLVCKVSDFGLSRAL 784

  Fly   894 ENASD-AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKS 957
            |:..: ||||.|||||:|||||||||||.|:|||||||:|||:|||::||||||||.:|||||.|
  Rat   785 EDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISS 849

  Fly   958 IEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTR-----PSPE 1017
            :|:||||||||.||.||:|||||||.|.|..||.|:.:||.|:.|...|:||..|.     |:|
  Rat   850 VEEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFSHVVSVLEALVHSPESLRATATVSRCPAP- 913

  Fly  1018 SDGNHILDGQRGQNIFISTDL----WLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITL 1078
            :......|.:.|.|  .:.||    ||:.|:|.||..||......:...:..:.||.:..:||||
  Rat   914 AFARSCFDLRAGGN--GNGDLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLHMNAQDVRALGITL 976

  Fly  1079 VGHQKKIL 1086
            :|||||||
  Rat   977 MGHQKKIL 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	70/188 (37%)
		FN3	387..476	CDD:238020	22/98 (22%)
		FN3	536..623	CDD:238020	24/86 (28%)
		EphA2_TM	640..738	CDD:464211	26/104 (25%)
		PTKc_EphR	736..1002	CDD:270629	175/266 (66%)
		SAM_1	1029..1092	CDD:425739	25/62 (40%)
Epha8	NP_001406194.1	EphR_LBD	30..202	CDD:470656	70/189 (37%)
		FN3	<325..>518	CDD:442628	55/236 (23%)
		FN3	439..530	CDD:238020	26/91 (29%)
		EphA2_TM	<561..631	CDD:464211	22/88 (25%)
		Protein Kinases, catalytic domain	629..895	CDD:473864	175/267 (66%)
		SAM_EPH-A8	932..994	CDD:188949	22/53 (42%)