DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and LOC572450

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_701258.6	Gene:	LOC572450 / 572450	-ID:	-	Length:	272	Species:	Danio rerio

Alignment Length:	277	Identity:	103/277 - (37%)
Similarity:	156/277 - (56%)	Gaps:	30/277 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 TILLIIISIHFKLAHADQVVLLDTTR-EATLEWTRYPYGPQAQTPGWVEESFTD-FVKGINWRSY 129
            ::|.|::......:.|::||||::.. :|.|.||.||      :.||.|.|..| ..|.|  |:|
Zfish     9 SLLWILLFNRTPESRAEEVVLLNSKESQAELGWTSYP------SNGWEEISGVDEKYKPI--RTY 65

  Fly   130 VVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFD----A 190
            .||:|...:.||||.:.:|.|....|::||:|||:|||:..||.:.||||||:||:.|.|    .
Zfish    66 QVCNVMEPSQNNWLQTGWIWRQGGQRIFIELQFTLRDCNSIPGVSGSCKETFNLLYAESDWDLGR 130

  Fly   191 ATREPPPWQTDSYRLIARIAAGEGRFNQNS----DVDINTEVKSIA-VNKKGVYFAFRDQGACIS 250
            .:||      |.|..|..|||.|. |.|..    .:.:||||:.|. :|:||.:.||:|.|||::
Zfish   131 VSRE------DRYSKIDTIAADES-FTQGDLGERKMKLNTEVREIGHLNRKGFHLAFQDVGACVA 188

  Fly   251 VLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYET---PTYLCKGDGKWTI 312
            :::|:|||..|.:..:|.|.|.:|......:.:.:..|.||:|:| .:|   |...|..:|:|.:
Zfish   189 LVSVRVYYKRCLSTVQNLAVFPDTVAEAAFSTLVEVRGACVNNSE-VDTDSPPRMHCSAEGEWLV 252

  Fly   313 LTGGCRCKAGYEPNYTN 329
            ..|.|.|.||||..:::
Zfish   253 PIGKCSCSAGYEEGHSS 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	78/185 (42%)
		FN3	387..476	CDD:238020
		FN3	536..623	CDD:238020
		EphA2_TM	644..736	CDD:291255
		PTKc_EphR	736..1002	CDD:270629
		Pkinase_Tyr	741..999	CDD:285015
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
LOC572450	XP_701258.6	EphR_LBD_A10	26..198	CDD:198455	78/186 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5332
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010