DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and epha8

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_009304537.1	Gene:	epha8 / 570677	ZFINID:	ZDB-GENE-041014-269	Length:	1030	Species:	Danio rerio

Alignment Length:	1083	Identity:	425/1083 - (39%)
Similarity:	588/1083 - (54%)	Gaps:	179/1083 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 DQVVLLDTTR-EATLEWTRYPYGPQAQTPGW-----VEESFTDFVKGINWRSYVVCDVAYHNVNN 141
            ::|.|||||: .....|..||      :.||     ::|.|:..      .:|.||:|...:.||
Zfish    28 NEVNLLDTTKISGDWGWLTYP------SHGWDAINEMDEYFSPI------HTYQVCNVMSPSQNN 80

  Fly   142 WLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATRE--PPPWQTDSYR 204
            ||.:.:|.|..|.|:|||::||:|||:..||...:|||||:|.:||.|   |:  ...|:: .:.
Zfish    81 WLRTNWIQRDGARRIYIEMKFTLRDCNSMPGVLGTCKETFNLYYYETD---RDVGTSIWES-QFS 141

  Fly   205 LIARIAAGEGRFNQNSDV---DINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVT 265
            .|..|||.|...|.:..|   .:|||::.:. :.|:|.|.||:|.||||::::|:|||..|..:.
Zfish   142 KIDTIAADESFTNVDLGVRRLKLNTEIRGVGPLGKRGFYLAFQDIGACIAIVSVRVYYKRCTGMA 206

  Fly   266 ENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNK 330
            .|.|.|.:..||.:.:.:.:..|.|||:||..:||...|..:|:|.:..|.|.|.||:|.:..|
Zfish   207 RNLAIFTDVVTGADSSSLVEVRGQCVDHAEERDTPKMYCSAEGEWLVPIGRCVCSAGFEEHRDN- 270

  Fly   331 TCTECPLGTFKSPEV--TKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNL 393
             |..|.:|.:| |..  .:|..||.:|::....:..|.|.:.|||...|....||..||:||.|:
Zfish   271 -CIACEVGFYK-PVAGDQQCGKCPLHSHSETRAALSCPCDANFYRSSTDPPSSPCTRPPSAPVNI 333

  Fly   394 TLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSP---------------NVV 443
             :..|:.||..:.|.:|.       :|..:   ||::|.:.|..|..               |.|
Zfish   334 -ISSVNGTSVSLEWVSPL-------DTGGR---SDVIYDVLCQKCDKDGLQCEDCRVGVGGGNGV 387

  Fly   444 YN-------------------------------------PSTDTFNETKITLTNLEPVTTYTVQI 471
            .|                                     |......|..:|:.||.....||.:|
Zfish   388 VNSNVNGASGDTSGAAGGTVGALNGLVVARSGAALVRFIPQRTGLTEPWVTVLNLAAHANYTFRI 452

  Fly   472 HAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFN 536
            .|:|.|:|:      |||.          ..:.::||                ||.....|.|..
Zfish   453 MALNGVTHL------SNEQ----------PQSVMVNI----------------TTNQAAPSEVMA 485

  Fly   537 LRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYG 601
            :|....:.....|.|.:|.|.:..:..|:::::.| :.:..:.:.|.:|.|.|.:.||...|.|.
Zfish   486 VRQENASQNSVTLFWHEPAQPNGVILEYDIKYYEK-DNEQQSYATLKSKNTSAKVSGLKPGTSYI 549

  Fly   602 FQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKH 666
            ||:|.:|:.|.|.:|..:..|| .....:.:.:|.|.:|..|.|||   ||.|:...:...|.:.
Zfish   550 FQIRARTSAGCGRFSQSVEIQT-GKAPPLRNTNVTIIWICMASVTG---LVTFLAVVICRKRQEE 610

  Fly   667 QDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIRE 731
            :....|...:         |:|          :|:|.......|..:|.|:||||||||.||:.|
Zfish   611 RCGYSKAFQD---------SDE----------EKMHYQNGHVSFPEARFYIDPHTYEDPCQAVHE 656

  Fly   732 FAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIM 796
            |||||:|:.|.||.|||.||||:||.||:|:|..  :|:.||:||||.|.:||.|.|||.|||||
Zfish   657 FAREIEASRIKIEKIIGSGEFGEVCYGRMKLPGK--RDVPVALKTLKAGYTEKQRRDFLAEASIM 719

  Fly   797 GQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSD 861
            .||||||||:|:||||||.|||||||||||||||:|||.:||:|..:||:.:|||||:||:||:|
Zfish   720 AQFDHPNVIHLEGVVTRSKPVMIITEYMENGSLDSFLRRHDGQFTIIQLVGILRGIAAGMTYLAD 784

  Fly   862 MNYVHRDLAARNVLVNAQLICKIADFGLSREIENASD-AYTTRGGKIPVRWTAPEAIAFRKFTSA 925
            :.||||||||||||||:.|:|||:||||||.:|:..| ||||.|||||:|||||||||:|||:|:
Zfish   785 LGYVHRDLAARNVLVNSNLVCKISDFGLSRVLEDDPDAAYTTSGGKIPIRWTAPEAIAYRKFSSS 849

  Fly   926 SDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRP 990
            |||||||||:||||||||:||||.:|:|||||:|:||||||||.||.||:.||||||||.|..||
Zfish   850 SDVWSYGVVMWEVMSYGEQPYWNLTNRDVIKSVEEGYRLPAPMGCPGALHTLMLDCWQKDRNERP 914

  Fly   991 TFASIVSTLDNLARQPQSL------------LTTRPSPESDGNHILDGQRGQNIFISTDLWLEHI 1043
            .|..||:.||.|.|.|::|            |..|..|:.....            |.|.||:.|
Zfish   915 KFCQIVTVLDKLIRTPETLKSVETLCRLNSPLMNRSIPDFTSCR------------SVDEWLDTI 967

  Fly  1044 KMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKIL 1086
            ||.||..||..........:..:....:..:|:||:||||||:
Zfish   968 KMGRYKDHFAAGGYRTLGHVMSMKQHDIQRLGVTLMGHQKKIM 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	70/186 (38%)
		FN3	387..476	CDD:238020	27/140 (19%)
		FN3	536..623	CDD:238020	22/86 (26%)
		EphA2_TM	644..736	CDD:291255	29/91 (32%)
		PTKc_EphR	736..1002	CDD:270629	189/266 (71%)
		Pkinase_Tyr	741..999	CDD:285015	185/258 (72%)
		SAM_1	1033..1092	CDD:278937	20/54 (37%)
		SAM	1039..1092	CDD:197735	18/48 (38%)
epha8	XP_009304537.1	EphR_LBD_A8	29..201	CDD:198454	70/187 (37%)
		FN3	327..>360	CDD:214495	12/43 (28%)
		FN3	480..571	CDD:238020	24/91 (26%)
		EphA2_TM	591..661	CDD:291255	29/91 (32%)
		PTKc_EphR_A	661..927	CDD:270651	189/267 (71%)
		Pkinase_Tyr	666..923	CDD:285015	185/258 (72%)
		SAM	952..1019	CDD:197735	21/71 (30%)
		SAM_EPH-A8	956..1020	CDD:188949	20/67 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010