DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eph and ntrk2b

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_001184090.2 Gene:ntrk2b / 570240 ZFINID:ZDB-GENE-010126-2 Length:799 Species:Danio rerio


Alignment Length:639 Identity:179/639 - (28%)
Similarity:295/639 - (46%) Gaps:132/639 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   442 VVYNPSTDTFNETKITLTNLE--PV-TTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNT 503
            |:.|.|.....|...||.:.|  |: |::.:....:.||..:|....:.|...|:..::      
Zfish   207 VICNASGSPTPELTWTLNSSEHPPLSTSHEISKMDLQSVLTLNGLSPNDNGRKLICSAE------ 265

  Fly   504 SLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKP-VQSDFPLEFYEVR 567
               ||        .||.|     .:|:|:..|...:|.:...:...:|..| |.:..|..  ::.
Zfish   266 ---NI--------VGQIE-----ATVMLNISFPPTVLELYLPERSQDWCIPFVVTGNPRP--DLH 312

  Fly   568 WF----PKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKT-------------NNGFGSY 615
            |:    |..|.:.|        .|:.|.:   .||||...::..|             :|.||..
Zfish   313 WYHEGKPLEEQEYI--------RTEIHDI---TNTEYHGCLKLDTPTHIHNGIYTLVASNEFGED 366

  Fly   616 SNMIYAQTLQ-------SVGSV--YDDSVQ--------------IRFIAGAIVTGVLFLVIFIIA 657
            ...:.|..::       .:..|  ||.:|.              :..|||..:||.:.:::|:  
Zfish   367 RGNVTAHFMRIPDVDHSGIEGVFYYDTTVSPDIPPLEDRVAVYIVVGIAGVALTGCILMLVFL-- 429

  Fly   658 TVYFMRSKH---------QDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNS 713
             .|...||.         .:|.|..|      ||.:.||..|:..::      .:.....:.|.:
Zfish   430 -KYGRSSKFGMKGSSSVISNDDDSAS------PLHHVSNGNNTPSSS------EMGPDAVIIGMT 481

  Fly   714 RSYV--DPHTYEDPNQAIRE--FAREIDANYITIEAIIGGGEFGDV----CRGRLKIPPNFVQDI 770
            :..|  :|..:.:|...::.  ..:.|..:.|.::..:|.|.||.|    |   ..:.|: .:.|
Zfish   482 KIPVIENPQYFRNPGSMLKSDTLVQHIKRHNILLKRELGEGAFGKVFLAEC---YNLSPD-QEKI 542

  Fly   771 DVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRV 835
            .||:||||. :||..|.||..||.::....|.:::...||...|:|::::.|||::|.|:.|||.
Zfish   543 LVAVKTLKE-ASESGRADFHREAELLTNLQHEHIVKFYGVCVESDPLIMVFEYMKHGDLNKFLRA 606

  Fly   836 N--------DGKFQTL------QLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIAD 886
            :        ||:...|      |::.:.:.||:||.||:..::||||||.||.||...|:.||.|
Zfish   607 HGPDAVLMADGQQSLLVELTQPQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGD 671

  Fly   887 FGLSREIENASDAYTTRG-GKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWS 950
            ||:||:: .::|.|...| ..:|:||..||:|.:|:||:.|||||.||||||:.:||::|::..|
Zfish   672 FGMSRDV-YSTDYYRVGGHTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGKQPWYQLS 735

  Fly   951 NQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLAR 1004
            |.:||:.|.:|..|..|..||:.:|.|||.|||::...|.....|.:.|.:||:
Zfish   736 NNEVIECITQGRVLQRPRTCPKEVYDLMLGCWQREPYMRLNIKEIHNLLQSLAK 789

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439
FN3 387..476 CDD:238020 9/36 (25%)
FN3 536..623 CDD:238020 20/104 (19%)
EphA2_TM 644..736 CDD:291255 18/104 (17%)
PTKc_EphR 736..1002 CDD:270629 110/284 (39%)
Pkinase_Tyr 741..999 CDD:285015 108/276 (39%)
SAM_1 1033..1092 CDD:278937
SAM 1039..1092 CDD:197735
ntrk2bNP_001184090.2 leucine-rich repeat 62..86 CDD:275378
LRR_8 85..144 CDD:290566
leucine-rich repeat 87..110 CDD:275378
leucine-rich repeat 111..133 CDD:275378
IG_like 194..279 CDD:214653 21/93 (23%)
Ig 205..275 CDD:143165 19/89 (21%)
Ig_TrkB_d5 297..375 CDD:143263 19/90 (21%)
PTKc_TrkB 507..796 CDD:270675 112/289 (39%)
Pkinase_Tyr 513..784 CDD:285015 108/276 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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