Protein Alignment Eph and epha7

DIOPT Version :9

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_001038444.2
• Gene: epha7 / 562195
• ZFINID: ZDB-GENE-030131-3745
• Length: 1016
• Species: Danio rerio
• Alignment Length: 1050
• Identity: 436/1050 - (41%)
• Similarity: 601/1050 - (57%)
• Gaps: 131/1050 - (12%)

  Fly    84 QVVLLDTTREAT-LEWTRYPYGPQAQTPGW-----VEESFTDFVKGINWRSYVVCDVAYHNVNNW 142
            :|:|||:..:.| |||...|      ..||     ::|::|..      |:|.||.|...|.|||
Zfish    31 EVILLDSKAQQTELEWISSP------PSGWEEISGLDENYTPI------RTYQVCQVMEPNQNNW 83

  Fly   143 LWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAAT----REPPPWQTDSY 203
            |.:.:|::|.|.|:::|::||:|||:..||...||||||:|.:.|.|...    ||      ..|
Zfish    84 LRTNWIEKGDAQRIFVELKFTLRDCNSLPGVVGSCKETFNLYYQETDVEVGRNIRE------SQY 142

  Fly   204 RLIARIAAGEGRFNQNS----DVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPA 263
            ..|..|||.|. |.|..    .:.:||||:.|. ::::|.|.||:|.||||::::|||||..|.:
Zfish   143 VKIDTIAADES-FTQGDLGERKMKLNTEVRIIGPLSRRGFYLAFQDVGACIALVSVKVYYKKCWS 206

  Fly   264 VTENFAHFNETPTGREITIIEKQNGTCVDNAEPY--ETPTYLCKGDGKWTILTGGCRCKAGYEPN 326
            :.||.|.|.:|.||.|.:.:.:..||||::||..  .:|...|..:|:|.:..|.|.||||:  :
Zfish   207 IIENLATFPDTVTGSEFSSLVEVEGTCVNDAEEEADNSPKMHCSAEGEWLVPIGKCICKAGF--H 269

  Fly   327 YTNKTCTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAP 390
            .....|..|..|.:| |.:..:|:.||.:|...:.||..|.|..|:||..:|...:.|..||:||
Zfish   270 QKGDACEPCGRGFYKSSSQDLQCSRCPAHSYNDREGSWRCDCEDGYYRALSDPPSVSCTRPPSAP 334

  Fly   391 TNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI----------KCNICSPNVVYN 445
            .|| |..::.|:..:.|:.||       :|..:   :|:.|:|          :|..|..||.|:
Zfish   335 QNL-LYNINHTTVSLEWTPPA-------DTGGR---NDVTYRIICRRCTWEPEECFPCGSNVGYS 388

  Fly   446 PSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFS---NTSLLN 507
            |......:|.:|:|:|.....||.::.|:|.||.::..:|      |.|...|..|   :|...|
Zfish   389 PQQSGLTDTYVTITDLLAHANYTFEVEAVNGVSDLSRTQR------LFAAVSIATSQAGSTFFTN 447

  Fly   508 IPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKV 572
            |.:....    .|::...|....:|.|...|   :......|.|.:|.|.:..:..||::::.|.
Zfish   448 ISVHFYT----SADMFEVTAPSQVSEVIKER---VQQHSVQLSWQEPDQPNGVITEYEIKYYEKD 505

  Fly   573 ELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTL-QSVGS---VYDD 633
            :.|.| .|.:.:|.|.|.:..|..:|.|.||:|..|..|:|.:...:...|. :|.||   :..:
Zfish   506 QKDRI-YSTVKSKSTSATVNNLKPSTAYVFQIRAFTAAGYGIFGPRLEVTTKEESTGSATVISSE 569

  Fly   634 SVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIV 698
            ...:..||...|.|.:.||..:...:...|.......|::....|.....
Zfish   570 QNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFQFK--------------- 619

  Fly   699 KKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIP 763
                       |..:::|:||.||||||:|:.:||:|:||:.|.||.:||.||||:||.||||:|
Zfish   620 -----------FPGTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLP 673

  Fly   764 PNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGS 828
            ..  :|:.|||||||.|.:||.|.|||.|||||||||||||::|:|||||..||||:.|||||||
Zfish   674 GK--RDVSVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEYMENGS 736

  Fly   829 LDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREI 893
            ||.|||.:||:|..:||:.||||||:||.|||||.||||||||||:|||:.|:||::||||||.|
Zfish   737 LDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVI 801

  Fly   894 ENASDA-YTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKS 957
            ::..:| |||.||||||||||.|||.:|||||||||||||:|:||||||||||||:.|||||||:
Zfish   802 DDDPEAVYTTTGGKIPVRWTAMEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKA 866

  Fly   958 IEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLT-----TRP-SP 1016
            ||:|||||||||||..|:|||||||||.|..||.|..||..||.:.|.|.:|.|     .|| ||
Zfish   867 IEEGYRLPAPMDCPPGLHQLMLDCWQKDRADRPKFDQIVGILDKMIRNPNTLKTPMGTCLRPISP 931

  Fly  1017 ESDGNHILDGQRGQNI--FISTDL---WLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGI 1076
                  :||    ||.  |.|..|   |||.|||.||..:|..|...:.:.::|:|.:.:..:||
Zfish   932 ------LLD----QNTPDFTSFRLVSEWLEAIKMERYMDNFTAAGYSSLESVARMTIEDVMSLGI 986

  Fly  1077 TLVGHQKKIL 1086
            :||||||||:
Zfish   987 SLVGHQKKIM 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	73/189 (39%)
		FN3	387..476	CDD:238020	27/98 (28%)
		FN3	536..623	CDD:238020	23/86 (27%)
		EphA2_TM	644..736	CDD:291255	20/91 (22%)
		PTKc_EphR	736..1002	CDD:270629	190/266 (71%)
		Pkinase_Tyr	741..999	CDD:285015	186/258 (72%)
		SAM_1	1033..1092	CDD:278937	25/56 (45%)
		SAM	1039..1092	CDD:197735	22/47 (47%)
epha7	NP_001038444.2	EphR_LBD_A7	29..205	CDD:198453	73/192 (38%)
		FN3	331..426	CDD:238020	30/105 (29%)
		FN3	464..555	CDD:238020	25/94 (27%)
		EphA2_TM	583..646	CDD:291255	19/88 (22%)
		PTKc_EphR_A	646..912	CDD:270651	190/267 (71%)
		Pkinase_Tyr	651..908	CDD:285015	186/258 (72%)
		SAM_EPH-A7	937..1006	CDD:188947	25/59 (42%)
		SAM	938..1005	CDD:197735	25/58 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	396	1.000	Domainoid score	I723
eggNOG	1	0.900	-	-		E2759_KOG0196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	753	1.000	Inparanoid score	I540
OMA	1	1.010	-	-		QHG45908
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	1	1.000	-	-		otm24639
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10548
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910