Protein Alignment Eph and ror2

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_001015834.1
• Gene: ror2 / 548551
• XenbaseID: XB-GENE-491498
• Length: 930
• Species: Xenopus tropicalis
• Alignment Length: 427
• Identity: 129/427 - (30%)
• Similarity: 194/427 - (45%)
• Gaps: 93/427 - (21%)

  Fly   648 VLFLVI------FIIATVYFM----RSK--------HQDDLDKKSTNHLPLPLDYASNEVNSMDT 694
            :|::::      .:||..:|:    |:|        .:..|....:..:.:||      :|....
 Frog   400 ILYILVPSIAIPLVIACFFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPL------MNQHKQ 458

  Fly   695 TPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGR 759
            .|.||:::|:..                        .|..|           :|...||.|.:|.
 Frog   459 QPKVKEINLSTV------------------------RFMEE-----------LGEDRFGKVYKGH 488

  Fly   760 LKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYM 824
            |.......|...|||||||.......|.:|..||.:..:..|||::.|.|.||:..|:.::..|.
 Frog   489 LFGTTPGEQTQTVAIKTLKDKVEVALREEFKHEAMMRSRLQHPNIVCLIGTVTKEQPMSMVFSYS 553

  Fly   825 ENGSLDTFL----------RVNDGK-----FQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNV 874
            ....|..||          ..:|.|     .:....:.::..||:||.:||..:.||:|||||||
 Frog   554 PLSDLHEFLVMRSPHSDVGSTDDDKTVKSTLEPTDFLHIVTQIAAGMEFLSSHHVVHKDLAARNV 618

  Fly   875 LVNAQLICKIADFGLSREIENASDAYTTRGGK-IPVRWTAPEAIAFRKFTSASDVWSYGVVLWEV 938
            ||..:|..||:|.||.||: .|:|.|...|.. :|:||.:||||.:.|.:..||:|||||:|||:
 Frog   619 LVFDKLSVKISDLGLFREV-YAADYYKLMGNSMLPIRWMSPEAITYGKCSVDSDIWSYGVLLWEI 682

  Fly   939 MSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASI---VSTLD 1000
            .|||.:||..:||||||:.:.....|..|.|||..:|.|||:||.:....||.|..|   :.|.:
 Frog   683 FSYGLQPYCGYSNQDVIEMVRNRQVLLCPDDCPAWIYTLMLECWSEFPARRPRFKDIHTRLRTWE 747

  Fly  1001 NLAR--------------QPQSLLTTRPSPESDGNHI 1023
            |::.              |..||.|:..|..|:..::
 Frog   748 NMSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYV 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020
		FN3	536..623	CDD:238020
		EphA2_TM	640..738	CDD:464211	16/107 (15%)
		PTKc_EphR	736..1002	CDD:270629	106/284 (37%)
		SAM_1	1029..1092	CDD:425739
ror2	NP_001015834.1	I-set	62..150	CDD:400151
		Ig strand B	77..81	CDD:409353
		Ig strand C	90..94	CDD:409353
		Ig strand E	116..120	CDD:409353
		Ig strand F	130..135	CDD:409353
		Ig strand G	143..146	CDD:409353
		CRD_TK_ROR2	168..305	CDD:143577
		KR	310..390	CDD:214527
		Protein Kinases, catalytic domain	463..746	CDD:473864	109/318 (34%)