DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and Alk

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster

Alignment Length:	434	Identity:	126/434 - (29%)
Similarity:	215/434 - (49%)	Gaps:	42/434 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   599 EYGFQVRCKTNNGFG-SYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFM 662
            |:..:|||...:|:. ...|....:..:..|     ....:::...::..:..|.|.|.|.::.:
  Fly  1068 EFRSKVRCICPDGWSLKRDNHTACEIREEAG-----KSSFQYLVSILMISLAVLFICIAALIFML 1127

  Fly   663 RSKHQDDLDKKSTNHLPLPLDYASNEV-NSMDTTPIVKKLHLNVTTPLFGNS---RSYVDPHTYE 723
            .:::|.....|..:.:.:..|.....: |::|.:      :||...|.:|..   ..::|.::..
  Fly  1128 YNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDS------NLNNFNPNYGCDGILNGHIDVNSLP 1186

  Fly   724 DPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCD 788
               |..|:..:.::|        :|.|.||:|.....:.......::.||:|||:.....:...|
  Fly  1187 ---QVARDSLQLVNA--------LGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEED 1240

  Fly   789 FLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVM----- 848
            ||.||:||.:|:|||:::|.||.....|..|:.|.:..|.|..|||.|....:...|:.|
  Fly  1241 FLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLF 1305

  Fly   849 -LRGIASGMSYLSDMNYVHRDLAARNVLVNAQ---LICKIADFGLSREIENASDAYTTRGGK--I 907
             ...:|.|..|:....::|||:||||.|::::   .:.||||||:||:|..:.  |..:|||  :
  Fly  1306 CALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSD--YYRKGGKAML 1368

  Fly   908 PVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPE 972
            |::|..|||.....|||.:||||:|::||||.|.|..||....|..|::.:.:|.||.:|.:||.
  Fly  1369 PIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPV 1433

  Fly   973 ALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSP 1016
            ::|::|.|||......||||.:::..| ....|..|::.. |.|
  Fly  1434 SIYKVMADCWNPTPEDRPTFITLLEHL-TACTQDASIMNA-PLP 1475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020
		FN3	536..623	CDD:238020	6/24 (25%)
		EphA2_TM	644..736	CDD:291255	16/95 (17%)
		PTKc_EphR	736..1002	CDD:270629	99/276 (36%)
		Pkinase_Tyr	741..999	CDD:285015	97/268 (36%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
Alk	NP_001261027.1	MAM	288..450	CDD:279023
		MAM	288..447	CDD:99706
		MAM	505..691	CDD:279023
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	101/289 (35%)
		TyrKc	1193..1460	CDD:197581	98/276 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455342
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940