Protein Alignment Eph and ephb1

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_002935121.2
• Gene: ephb1 / 493336
• XenbaseID: XB-GENE-488626
• Length: 987
• Species: Xenopus tropicalis
• Alignment Length: 1066
• Identity: 450/1066 - (42%)
• Similarity: 619/1066 - (58%)
• Gaps: 126/1066 - (11%)

  Fly    62 MSLLRTILLIIISIHFKLAHADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINW 126
            |.|...:||::.||..::...::.::...|..|.|.||..|      :.||.|.|..|  :.:|.
 Frog     1 MELNVLLLLLLCSIGSQVGAVEETLMDTRTATAELGWTANP------SSGWEEVSGYD--ENLNT 57

  Fly   127 -RSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDA 190
             |:|.||:|...:.||||.:.||.|..|:|:|:|::||:||||..|....||||||:|.:||.|:
 Frog    58 IRTYQVCNVFGPSQNNWLLTTFIPRRGAHRVYVEMRFTVRDCSSLPNVPGSCKETFNLYYYETDS 122

  Fly   191 --ATREPPPWQTDSYRLIARIAAGEGRFNQNSDVD-------INTEVKSIA-VNKKGVYFAFRDQ 245
              ..:....|....|..:..|||.|. |:|   ||       :||||:|.. :.:.|.|.||:|.
 Frog   123 NIDNKISTFWNESPYLKVDTIAADES-FSQ---VDFGGRLMKVNTEVRSFGPLTRSGFYLAFQDY 183

  Fly   246 GACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYL-CKGDGK 309
            |||:|:|:|:|::..||:|.:|||.|.||.||.|.|.:....|||:.|||..:.|..| |.|||:
 Frog   184 GACMSLLSVRVFFKKCPSVVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYCNGDGE 248

  Fly   310 WTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPE-VTKCTPCPPNSNASKTGSPFCKCASGFYR 373
            |.:..|.|.|||||||. .:..|..||...||:.: :..|.|||.||.::...||.|.|.:|:||
 Frog   249 WMVPIGKCTCKAGYEPE-NHVVCKACPAAMFKANQGMGVCAPCPANSRSTSEASPICICRNGYYR 312

  Fly   374 HPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI----- 433
            ...|....||.|.|:.|.|: :..|::|:..:.|..|       .||..:   .|:.|.|
 Frog   313 ADFDTPEAPCTSVPSGPRNV-ISIVNETAITLEWHPP-------RETGGR---DDVTYNIICKKC 366

  Fly   434 -----KCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEF-KRHSNESSL 492
                 .|:.|..||.:.|......:|::.::||...|.||.:|.|||.|::.:.| .:|
 Frog   367 QSDRRGCSRCDDNVEFVPRQMGLTDTRVFISNLWAHTPYTFEIQAINGVTNKSPFPPQH------ 425

  Fly   493 VAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQS 557
            |:| :|..:..:..::|: :::||.                         |.|...|.|.:|.|.
 Frog   426 VSV-NITTNQAAPSSVPI-MHQVKA-------------------------TMKSITLSWPQPEQP 463

  Fly   558 DFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQ 622
            :..:..||:|::.| :....|.|...::...|.|.||.....|..|||.:|..|:|.:|:.:..|
 Frog   464 NGIILDYEIRYYEK-DHHEFNSSLARSQTNTASIEGLRPGVVYVVQVRARTVAGYGKFSSKMCFQ 527

  Fly   623 TLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATV-------YFMRSKHQDDLDKKSTNHLPL 680
            ||.:.....:...|:..|||:...||:|:|..:..::       |...:.:.|.|...||..
 Frog   528 TLTAEDYKSELREQLPLIAGSAAAGVVFIVSLVAISIVCSRKRTYSKEAVYSDKLQHYSTGR--- 589

  Fly   681 PLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEA 745
                         .:|.:|               .|:||.||||||:|:||||:|||.:::.||.
 Frog   590 -------------GSPGMK---------------IYIDPFTYEDPNEAVREFAKEIDVSFVKIEE 626

  Fly   746 IIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGV 810
            :||.||||:|.:||||:|..  ::|.|||||||.|.|||.|.|||:||||||||||||:|.|:||
 Frog   627 VIGAGEFGEVYKGRLKLPSK--REIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGV 689

  Fly   811 VTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVL 875
            ||:|.|||||||:||||:||:|||.|||:|..:||:.||||||:||.|||:||||||||||||:|
 Frog   690 VTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNIL 754

  Fly   876 VNAQLICKIADFGLSREI-ENASD-AYTTR-GGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWE 937
            ||:.|:||::||||||.: ::.|| .||:. |||||||||||||||:|||||||||||||:|:||
 Frog   755 VNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWE 819

  Fly   938 VMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNL 1002
            ||||||||||:.||||||.:||:.||||.|||||.||:|||||||||.|..||.|..||:|||.:
 Frog   820 VMSYGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFGEIVNTLDKM 884

  Fly  1003 ARQPQSLLTTRPSPESDGNHILDGQRGQ-NIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRL 1066
            .|.|.||.|....|......:||..... ..|.|.|.||..|||.:|...|..:...:.|.::::
 Frog   885 IRNPASLKTVATIPAVPSQPLLDHSIPDITAFTSVDDWLSAIKMGQYRDIFLSSGFTSLQLVAQM 949

  Fly  1067 TAQQLSDMGITLVGHQKKILHQARQL 1092
            |::.|..:||||.|||||||:..:.:
 Frog   950 TSEDLLRIGITLAGHQKKILNSIQSM 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	72/185 (39%)
		FN3	387..476	CDD:238020	26/98 (27%)
		FN3	536..623	CDD:238020	24/86 (28%)
		EphA2_TM	640..738	CDD:464211	30/104 (29%)
		PTKc_EphR	736..1002	CDD:270629	190/268 (71%)
		SAM_1	1029..1092	CDD:425739	24/63 (38%)
ephb1	XP_002935121.2	EphR_LBD_B1	23..198	CDD:198444	72/186 (39%)
		FN3	326..432	CDD:238020	33/123 (27%)
		fn3	422..521	CDD:394996	30/132 (23%)
		EphA2_TM	545..619	CDD:464211	30/104 (29%)
		PTKc_EphR_B	617..885	CDD:173638	190/269 (71%)
		SAM_EPH-B1	911..978	CDD:188950	24/65 (37%)