DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eph and ephb1

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:XP_002935121.2 Gene:ephb1 / 493336 XenbaseID:XB-GENE-488626 Length:987 Species:Xenopus tropicalis


Alignment Length:1066 Identity:450/1066 - (42%)
Similarity:619/1066 - (58%) Gaps:126/1066 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 MSLLRTILLIIISIHFKLAHADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINW 126
            |.|...:||::.||..::...::.::...|..|.|.||..|      :.||.|.|..|  :.:|.
 Frog     1 MELNVLLLLLLCSIGSQVGAVEETLMDTRTATAELGWTANP------SSGWEEVSGYD--ENLNT 57

  Fly   127 -RSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDA 190
             |:|.||:|...:.||||.:.||.|..|:|:|:|::||:||||..|....||||||:|.:||.|:
 Frog    58 IRTYQVCNVFGPSQNNWLLTTFIPRRGAHRVYVEMRFTVRDCSSLPNVPGSCKETFNLYYYETDS 122

  Fly   191 --ATREPPPWQTDSYRLIARIAAGEGRFNQNSDVD-------INTEVKSIA-VNKKGVYFAFRDQ 245
              ..:....|....|..:..|||.|. |:|   ||       :||||:|.. :.:.|.|.||:|.
 Frog   123 NIDNKISTFWNESPYLKVDTIAADES-FSQ---VDFGGRLMKVNTEVRSFGPLTRSGFYLAFQDY 183

  Fly   246 GACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYL-CKGDGK 309
            |||:|:|:|:|::..||:|.:|||.|.||.||.|.|.:....|||:.|||..:.|..| |.|||:
 Frog   184 GACMSLLSVRVFFKKCPSVVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYCNGDGE 248

  Fly   310 WTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPE-VTKCTPCPPNSNASKTGSPFCKCASGFYR 373
            |.:..|.|.|||||||. .:..|..||...||:.: :..|.|||.||.::...||.|.|.:|:||
 Frog   249 WMVPIGKCTCKAGYEPE-NHVVCKACPAAMFKANQGMGVCAPCPANSRSTSEASPICICRNGYYR 312

  Fly   374 HPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI----- 433
            ...|....||.|.|:.|.|: :..|::|:..:.|..|       .||..:   .|:.|.|     
 Frog   313 ADFDTPEAPCTSVPSGPRNV-ISIVNETAITLEWHPP-------RETGGR---DDVTYNIICKKC 366

  Fly   434 -----KCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEF-KRHSNESSL 492
                 .|:.|..||.:.|......:|::.::||...|.||.:|.|||.|::.:.| .:|      
 Frog   367 QSDRRGCSRCDDNVEFVPRQMGLTDTRVFISNLWAHTPYTFEIQAINGVTNKSPFPPQH------ 425

  Fly   493 VAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQS 557
            |:| :|..:..:..::|: :::||.                         |.|...|.|.:|.|.
 Frog   426 VSV-NITTNQAAPSSVPI-MHQVKA-------------------------TMKSITLSWPQPEQP 463

  Fly   558 DFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQ 622
            :..:..||:|::.| :....|.|...::...|.|.||.....|..|||.:|..|:|.:|:.:..|
 Frog   464 NGIILDYEIRYYEK-DHHEFNSSLARSQTNTASIEGLRPGVVYVVQVRARTVAGYGKFSSKMCFQ 527

  Fly   623 TLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATV-------YFMRSKHQDDLDKKSTNHLPL 680
            ||.:.....:...|:..|||:...||:|:|..:..::       |...:.:.|.|...||..   
 Frog   528 TLTAEDYKSELREQLPLIAGSAAAGVVFIVSLVAISIVCSRKRTYSKEAVYSDKLQHYSTGR--- 589

  Fly   681 PLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEA 745
                         .:|.:|               .|:||.||||||:|:||||:|||.:::.||.
 Frog   590 -------------GSPGMK---------------IYIDPFTYEDPNEAVREFAKEIDVSFVKIEE 626

  Fly   746 IIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGV 810
            :||.||||:|.:||||:|..  ::|.|||||||.|.|||.|.|||:||||||||||||:|.|:||
 Frog   627 VIGAGEFGEVYKGRLKLPSK--REIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGV 689

  Fly   811 VTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVL 875
            ||:|.|||||||:||||:||:|||.|||:|..:||:.||||||:||.|||:||||||||||||:|
 Frog   690 VTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNIL 754

  Fly   876 VNAQLICKIADFGLSREI-ENASD-AYTTR-GGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWE 937
            ||:.|:||::||||||.: ::.|| .||:. |||||||||||||||:|||||||||||||:|:||
 Frog   755 VNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWE 819

  Fly   938 VMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNL 1002
            ||||||||||:.||||||.:||:.||||.|||||.||:|||||||||.|..||.|..||:|||.:
 Frog   820 VMSYGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFGEIVNTLDKM 884

  Fly  1003 ARQPQSLLTTRPSPESDGNHILDGQRGQ-NIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRL 1066
            .|.|.||.|....|......:||..... ..|.|.|.||..|||.:|...|..:...:.|.::::
 Frog   885 IRNPASLKTVATIPAVPSQPLLDHSIPDITAFTSVDDWLSAIKMGQYRDIFLSSGFTSLQLVAQM 949

  Fly  1067 TAQQLSDMGITLVGHQKKILHQARQL 1092
            |::.|..:||||.|||||||:..:.:
 Frog   950 TSEDLLRIGITLAGHQKKILNSIQSM 975

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 72/185 (39%)
FN3 387..476 CDD:238020 26/98 (27%)
FN3 536..623 CDD:238020 24/86 (28%)
EphA2_TM 644..736 CDD:291255 25/98 (26%)
PTKc_EphR 736..1002 CDD:270629 190/268 (71%)
Pkinase_Tyr 741..999 CDD:285015 185/260 (71%)
SAM_1 1033..1092 CDD:278937 24/58 (41%)
SAM 1039..1092 CDD:197735 21/52 (40%)
ephb1XP_002935121.2 EphR_LBD_B1 23..198 CDD:198444 72/186 (39%)
FN3 326..432 CDD:238020 33/123 (27%)
FN3 420..528 CDD:238020 32/141 (23%)
EphA2_TM 549..617 CDD:373140 25/98 (26%)
PTKc_EphR_B 617..885 CDD:173638 190/269 (71%)
SAM_EPH-B1 911..978 CDD:188950 24/65 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 397 1.000 Domainoid score I749
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H20936
Inparanoid 1 1.050 763 1.000 Inparanoid score I545
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm49458
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
88.060

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