DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and NTRK2

DIOPT Version :10

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_006171.2 Gene:NTRK2 / 4915 HGNCID:8032 Length:838 Species:Homo sapiens


Alignment Length:873 Identity:208/873 - (23%)
Similarity:328/873 - (37%) Gaps:316/873 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   402 SAIISWSAPAK--------------NESFSSETNSKIYHSDIVYKIKCNICSPNVVYNP-----S 447
            |:.|.|..||.              ..:|:..|:.|...|    :|.|:..||.:|..|     |
Human     2 SSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSAS----RIWCSDPSPGIVAFPRLEPNS 62

  Fly   448 TDTFNETKITLTN---LEPVTTYTVQIHA----------------------INSVSHIN------ 481
            .|..|.|:|.:.|   ||.:....|:.:.                      .:::.|||      
Human    63 VDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKL 127

  Fly   482 -----EFKRHSNESSLVAV-------------------------SDIVFSNTSLLNIPL------ 510
                 :..||.:.|.|:.|                         .|:...|.|..||||      
Human   128 TSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIP 192

  Fly   511 ----------------------------------------------DLNEVKTGQAEIVFTT--- 526
                                                          .:||....|..:..|.   
Human   193 NCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISS 257

  Fly   527 -------------------ESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKV 572
                               :||.|:..|...|..:.:..:|..|..|         :.|:..||.
Human   258 DDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIP---------FTVKGNPKP 313

  Fly   573 ELD-AINKSALNTKE---TKAHIVG----------------------LLENTEYGFQVRCKTNNG 611
            .|. ..|.:.||..:   ||.|:..                      |:...|||...:..:.:.
Human   314 ALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHF 378

  Fly   612 FG----------SYSNMIYAQTLQSVGSVYDD-------------------------SVQIRFIA 641
            .|          :|.::||    :..|:..:|                         ||....:.
Human   379 MGWPGIDDGANPNYPDVIY----EDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVI 439

  Fly   642 GAIVTGVLFLVIFIIATV-----------YF----MRSKH--------QDDLDKKSTNHLPLPLD 683
            .::|...|.:::|::...           :|    ::|:.        .:|.|..|      ||.
Human   440 ASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSAS------PLH 498

  Fly   684 YASNEVNS--------------MDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAR 734
            :.||..|:              |...|:::      ....||.:.|.:.|.|          |.:
Human   499 HISNGSNTPSSSEGGPDAVIIGMTKIPVIE------NPQYFGITNSQLKPDT----------FVQ 547

  Fly   735 EIDANYITIEAIIGGGEFGDV----CRGRLKIPPNFVQD-IDVAIKTLKPGSSEKARCDFLTEAS 794
            .|..:.|.::..:|.|.||.|    |   ..:.|.  || |.||:|||| .:|:.||.||..||.
Human   548 HIKRHNIVLKRELGEGAFGKVFLAEC---YNLCPE--QDKILVAVKTLK-DASDNARKDFHREAE 606

  Fly   795 IMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVN--------DGKFQT----LQLIV 847
            ::....|.:::...||....:|::::.|||::|.|:.|||.:        :|...|    .|::.
Human   607 LLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH 671

  Fly   848 MLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRG-GKIPVRW 911
            :.:.||:||.||:..::||||||.||.||...|:.||.|||:||:: .::|.|...| ..:|:||
Human   672 IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDV-YSTDYYRVGGHTMLPIRW 735

  Fly   912 TAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQ 976
            ..||:|.:||||:.|||||.||||||:.:||::|::..||.:||:.|.:|..|..|..||:.:|:
Human   736 MPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYE 800

  Fly   977 LMLDCWQKQRTHRPTFASIVSTLDNLAR 1004
            |||.|||::...|.....|.:.|.|||:
Human   801 LMLGCWQREPHMRKNIKGIHTLLQNLAK 828

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439
FN3 387..476 CDD:238020 24/117 (21%)
FN3 536..623 CDD:238020 22/122 (18%)
EphA2_TM 640..738 CDD:464211 22/134 (16%)
PTKc_EphR 736..1002 CDD:270629 111/283 (39%)
SAM_1 1029..1092 CDD:425739
NTRK2NP_006171.2 LRR_8 92..150 CDD:404697 8/57 (14%)
LRR 1 92..113 0/20 (0%)
LRR 2 116..137 3/20 (15%)
LRRCT_2 151..195 CDD:465313 7/43 (16%)
Ig 205..283 CDD:472250 7/77 (9%)
Ig strand B 214..218 CDD:409353 0/3 (0%)
Ig strand C 227..230 CDD:409353 0/2 (0%)
Ig strand E 245..252 CDD:409353 1/6 (17%)
Ig strand F 262..268 CDD:409353 0/5 (0%)
Ig strand G 276..279 CDD:409353 0/2 (0%)
IgI_TrkB_d5 286..379 CDD:409441 18/101 (18%)
Ig strand A 286..294 CDD:409441 1/7 (14%)
Ig strand A' 295..298 CDD:409441 0/2 (0%)
Ig strand B 301..309 CDD:409441 3/16 (19%)
Ig strand C 312..319 CDD:409441 2/6 (33%)
Ig strand C' 322..325 CDD:409441 0/2 (0%)
Ig strand D 330..335 CDD:409441 2/4 (50%)
Ig strand E 341..349 CDD:409441 0/7 (0%)
Ig strand F 357..365 CDD:409441 1/7 (14%)
Ig strand G 368..376 CDD:409441 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..514 7/28 (25%)
PTKc_TrkB 548..835 CDD:270675 114/288 (40%)
Blue background indicates that the domain is not in the aligned region.

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