Protein Alignment Eph and Src64B

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Alignment Length: 636
• Identity: 178/636 - (27%)
• Similarity: 258/636 - (40%)
• Gaps: 186/636 - (29%)

  Fly   434 KCNICS-----------PNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEF---- 483
            ||  ||           |...|..|..||.:|                        |||..
  Fly     4 KC--CSKRQDQELALAYPTGGYKKSDYTFGQT------------------------HINSSGGGN 42

  Fly   484 ------KRHSNESSL-------------VAVS-----DIVFSNTSLLNIP--------------- 509
                  ::|:|..||             :.:.     ||:...|:...:|
  Fly    43 MGGVLGQKHNNGGSLDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYK 107

  Fly   510 ----LDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFY-EVR-- 567
                .||:.:|..:.|::..|||..      .|::.:|.:...|         .||.|. |.|
  Fly   108 SRDESDLSFMKGDRMEVIDDTESDW------WRVVNLTTRQEGL---------IPLNFVAEERSV 157

  Fly   568 ----WFPKVELDAINKSALNTKETKAHIVGLLENTEYG-FQVRCKTNNGFGSYSNMIYAQTLQSV 627
                ||.:           |....:|..:.|.|....| |.||...:|..|
  Fly   158 NSEDWFFE-----------NVLRKEADKLLLAEENPRGTFLVRPSEHNPNG-------------- 197

  Fly   628 GSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPL-PLDYASNEVNS 691
                                            |.:..|..:|.......|..: |||.....:.:
  Fly   198 --------------------------------YSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIAT 230

  Fly   692 MDTTPIVKKLHL-----NVTTPLFGNSRSYVDPHTYE-DPNQAIREFAREIDANYITIEAIIGGG 750
            ..|.|.::.|.:     |........||....|.... |....:|: ..||..:.|.:...:|.|
  Fly   231 NQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELRD-KYEIPRSEIQLLRKLGRG 294

  Fly   751 EFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSN 815
            .||:|..|:.:      ..||||:|||:.|:...|.  ||.||:||.:|.|..::.|..|.::..
  Fly   295 NFGEVFYGKWR------NSIDVAVKTLREGTMSTAA--FLQEAAIMKKFRHNRLVALYAVCSQEE 351

  Fly   816 PVMIITEYMENGSLDTFLRVNDGKFQTLQ-LIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQ 879
            |:.|:.|||..|||..|||..||::...: ||.:...:||||.||.....:||||||||||:...
  Fly   352 PIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGEN 416

  Fly   880 LICKIADFGLSREIENASDAYTTR-GGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGE 943
            .:.||.||||:|.|  |.|.|..: |.:.||:|||||||.:.||:..|||||||::|.|:.:||:
  Fly   417 NVAKICDFGLARVI--ADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQ 479

  Fly   944 RPYWNWSNQDVIKSIEKGYRLPAPMD--CPEALYQLMLDCWQKQRTHRPTF 992
            .||....:::||::||:|:|:|.|.:  .|:.:|||:|.||......||||
  Fly   480 VPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTF 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	10/52 (19%)
		FN3	536..623	CDD:238020	20/94 (21%)
		EphA2_TM	640..738	CDD:464211	18/104 (17%)
		PTKc_EphR	736..1002	CDD:270629	113/261 (43%)
		SAM_1	1029..1092	CDD:425739
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	24/157 (15%)
		PTKc_Src_like	289..538	CDD:270630	111/252 (44%)
		SH3_Src_like	99..150	CDD:212779	12/65 (18%)