DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eph and epha2

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_001006765.1 Gene:epha2 / 448450 XenbaseID:XB-GENE-5761259 Length:974 Species:Xenopus tropicalis


Alignment Length:1059 Identity:411/1059 - (38%)
Similarity:574/1059 - (54%) Gaps:152/1059 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 ILLIIISIHFKLAHADQVVLLDTTR-EATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVV 131
            :|.:::|..|......:|||||..: :..|.|..:|||     .||  :...:.:.|.....|.|
 Frog     9 VLTLLLSNVFIALQTKEVVLLDFEKTQGELGWLTHPYG-----KGW--DLLQNVMNGSMIYIYSV 66

  Fly   132 CDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSL--LFYEFDAATRE 194
            |:|.....:|||.:.:|.|..|.|:::|::||:|||:.|||.:.:|||||:|  |..:.|..|. 
 Frog    67 CNVQEGEQDNWLRTNWIYRSEAQRIFVELKFTVRDCNSFPGGSGTCKETFNLYSLESDIDYGTN- 130

  Fly   195 PPPWQTDSYRLIARIAAGEGRFN---QNSDVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVK 255
               :|...:|.|..||..|....   .:.:|.:|.||:|:. :::||.|.||:|.|||:::|:|:
 Frog   131 ---FQKRQFRKIDTIAPDEITVQADFASRNVKVNVEVRSVGPLSRKGFYLAFQDIGACVALLSVR 192

  Fly   256 VYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNA--EPYETPTYLCKGDGKWTILTGGCR 318
            :||..||:|.:..|.|.||..|.:...:.|.:|.||:||  ...|.||..|..||:|.:..|.|.
 Frog   193 IYYKKCPSVVQGMAQFPETVAGTDSQSLAKVSGQCVNNAVSATGEVPTMHCNTDGEWLVPIGHCL 257

  Fly   319 CKAGYEPNYTNKTCTECPLGTFKSPEVTK--CTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHM 381
            |:.|||.  ...||..|..|.||| |.:.  |.|||.::..:...:.||.|..||:|..:|....
 Frog   258 CQPGYEK--VGDTCQACKPGFFKS-ETSNGPCLPCPDHTEPTSQAATFCPCNDGFFRATSDSNSA 319

  Fly   382 PCYSPPAAPTNLTLLFVDQTS-AIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSP----- 440
            ||.|.|:||.:.|.  ||..| .::.|..|:.:..          .|||.|.:.|..|.|     
 Frog   320 PCTSFPSAPRDFTA--VDMGSKVVLRWLPPSNSGG----------RSDITYTVTCEKCPPETGDC 372

  Fly   441 ----NVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFS 501
                |:.|:.:......|.|::.:|||...|:..:.|.|.||...                   |
 Frog   373 VPCDNIRYSETPRDLKGTTISIMDLEPHLNYSFTVEARNGVSASG-------------------S 418

  Fly   502 NTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDAD---LEWDKPVQSDFPLEF 563
            :.|...:.:.||:           ||...:::|.      :.|:..:   |.|..|.:....:..
 Frog   419 SRSYAALRISLNQ-----------TEPPKVTSVI------LENQGTNSLGLSWSVPARQQSRVWK 466

  Fly   564 YEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVG 628
            |||.:..|  .|..:.|....:.....:|.|...|.|..:|:..|..|.|.||......||  :|
 Frog   467 YEVTYSKK--HDGNSYSVQRCEGNAVTLVKLAPGTTYVVRVQTLTQEGVGIYSKDYEFDTL--LG 527

  Fly   629 SVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSK-----HQDDLD---KKSTNHLPLPLDYA 685
            .  ::|.....|.||| .|.|.:|:|:...::..||:     .|.|.|   .|.....||     
 Frog   528 E--ENSNNAAVIGGAI-AGSLLIVVFVAVIIFMHRSRRNPNTRQSDEDIYFSKPEQLKPL----- 584

  Fly   686 SNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGG 750
                                        ::|||||||||||:|:.:|..||..|.||.:.:||.|
 Frog   585 ----------------------------KTYVDPHTYEDPNKAVLKFTTEISPNSITRQKVIGAG 621

  Fly   751 EFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSN 815
            |||:|.:|.||:|..  :::.|||||||.|.:||.|.|||:||||||||.|.|:|.|:|||:|..
 Frog   622 EFGEVFKGILKLPGK--KEVPVAIKTLKAGYTEKQRIDFLSEASIMGQFCHHNIIRLEGVVSRYK 684

  Fly   816 PVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQL 880
            |:||:||:||||:||.||:.|||:|..:||:.||||||:||.|||:||||||||||||:|||:||
 Frog   685 PMMIVTEHMENGALDKFLKDNDGEFCPIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSQL 749

  Fly   881 ICKIADFGLSREIENASDA-YTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGER 944
            :||::||||||.:|:..:| |||.|||||:||||||||::|||||||||||||:|:|||||||||
 Frog   750 VCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSYGIVMWEVMSYGER 814

  Fly   945 PYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSL 1009
            |||..|||:|:|:|.:|:|||||||||.|:||||:.|||::|..||.|..|||.||.|.|.|.||
 Frog   815 PYWEMSNQEVMKAINEGFRLPAPMDCPSAIYQLMMQCWQQERNRRPKFPDIVSILDKLIRAPDSL 879

  Fly  1010 LT-----TRPS---PESDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRL 1066
            .|     .|.|   |.:.|:..:.       |.:...|||.|||.:|...|..:...:..:|..:
 Frog   880 KTLADFDPRISIRLPSTSGSEGMP-------FRTIAEWLESIKMQQYNEFFMASPYNSMDKIILM 937

  Fly  1067 TAQQLSDMGITLVGHQKKI 1085
            ....:..:||...||||:|
 Frog   938 NQDDIKHLGIRQTGHQKRI 956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 66/181 (36%)
FN3 387..476 CDD:238020 25/98 (26%)
FN3 536..623 CDD:238020 20/89 (22%)
EphA2_TM 644..736 CDD:291255 26/99 (26%)
PTKc_EphR 736..1002 CDD:270629 177/266 (67%)
Pkinase_Tyr 741..999 CDD:285015 173/258 (67%)
SAM_1 1033..1092 CDD:278937 17/53 (32%)
SAM 1039..1092 CDD:197735 16/47 (34%)
epha2NP_001006765.1 EphR_LBD_A2 25..198 CDD:198448 66/183 (36%)
FN3 325..416 CDD:214495 28/102 (27%)
FN3 434..524 CDD:238020 21/97 (22%)
EphA2_TM 540..607 CDD:373140 27/100 (27%)
PTKc_EphR_A2 606..873 CDD:133194 178/268 (66%)
SAM_EPH-A2 900..969 CDD:188942 17/64 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 397 1.000 Domainoid score I749
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 763 1.000 Inparanoid score I545
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm49458
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
66.060

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