Protein Alignment Eph and drl

DIOPT Version :9

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Alignment Length: 633
• Identity: 140/633 - (22%)
• Similarity: 246/633 - (38%)
• Gaps: 166/633 - (26%)

  Fly   498 IVFSNTSLLNIPLDLNEVKT---GQAEIVFTTESVLLSTVFNLRILAITN-KDADLEWDKPVQSD 558
            ::.|..:.|||.|:|:||..   ..||:.:..|..:.....|..:....| .|....|...|  |
  Fly    14 LIASGQAHLNIFLNLHEVLRLIGVSAELYYVREGAINDYALNFAVPVPANISDVTFTWQSLV--D 76

  Fly   559 FPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGL-------LENTEYGFQVRCK--------- 607
            .||.:            :||.:..:|:.....|:.:       :|...:|..::|.
  Fly    77 HPLPY------------SINIATSDTEVLPRPILNISRIGDVPVEPQTWGIALKCSGTRNAEVTV 129

  Fly   608 -----------TNNGFGSYSNMIY-------AQTLQSVGSVYDD-------------SVQIRFI- 640
                       |||.    :|:|:       .:...|....|||             ...|.::
  Fly   130 TINVEVILDRATNNN----TNLIFKRKKICLREEQDSAHEEYDDDDLDLLQTARKGHGGDIHYVD 190

  Fly   641 -------------------------------------------------AGAIVT----GVLFLV 652
                                                             |..:||    |:|.||
  Fly   191 RNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSKRDFDPMLRENLVPPASGLVTLIVGGILALV 255

  Fly   653 IF--IIATVYFMR---SKHQDD----LDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTP 708
            :.  :|...|..:   .:|..:    :...|...||.....|.|.:....:|  :...:..:|.|
  Fly   256 LVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPST--ITPTYATLTRP 318

  Fly   709 LFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVA 773
            .    |.|  .|..|:.|:.::|..  :....:.:..::..|.||.:.||..    |..|  :|.
  Fly   319 F----REY--EHEPEEFNRRLQELT--VQKCRVRLSCLVQEGNFGRIYRGTY----NDCQ--EVL 369

  Fly   774 IKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTR--SNPVMIITEYMENGS---LDTFL 833
            :||:...:|:......|.|:.::.:..||||:.:.|:...  :.|.::   |...||   |.:||
  Fly   370 VKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL---YAATGSVRNLKSFL 431

  Fly   834 RVNDGKF----QTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIE 894
            :  |..:    .|:|.::|...:|..|.:|.:...:|:|:||||.:::.||..|:.|..|||::.
  Fly   432 Q--DPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLF 494

  Fly   895 NASDAYTTRG-GKI-PVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKS 957
            ...  |.:.| |:. |::|.:.||:....:...|||||:||::||:.:.|:.||......::...
  Fly   495 PGD--YNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHY 557

  Fly   958 IEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQ 1005
            ::.||||..|.:||:.|:.:|..||......||:|:.:...|.....|
  Fly   558 LKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQ 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020
		FN3	536..623	CDD:238020	20/121 (17%)
		EphA2_TM	644..736	CDD:291255	23/104 (22%)
		PTKc_EphR	736..1002	CDD:270629	79/276 (29%)
		Pkinase_Tyr	741..999	CDD:285015	78/268 (29%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
drl	NP_001260566.1	WIF	21..157	CDD:128745	30/153 (20%)
		PTK_Ryk	336..606	CDD:270639	80/285 (28%)
		Pkinase_Tyr	343..599	CDD:285015	78/268 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455343
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940